Entity

Time filter

Source Type

Cork, Ireland

Savignac H.M.,Alimentary Pharmabiotic Center | Savignac H.M.,University College Cork | Savignac H.M.,University of Reading | Tramullas M.,Alimentary Pharmabiotic Center | And 6 more authors.
Behavioural Brain Research | Year: 2015

Increasing evidence suggests that a brain-gut-microbiome axis exists, which has the potential to play a major role in modulating behaviour. However, the role of this axis in cognition remains relatively unexplored. Probiotics, which are commensal bacteria offering potential health benefit, have been shown to decrease anxiety, depression and visceral pain-related behaviours. In this study, we investigate the potential of two Bifidobacteria strains to modulate cognitive processes and visceral pain sensitivity. Adult male BALB/c mice were fed daily for 11 weeks with B. longum 1714, B. breve 1205 or vehicle treatment. Starting at week 4, animals were behaviourally assessed in a battery of tests relevant to different aspects of cognition, as well as locomotor activity and visceral pain. In the object recognition test, B. longum 1714-fed mice discriminated between the two objects faster than all other groups and B. breve 1205-fed mice discriminated faster than vehicle animals. In the Barnes maze, B. longum 1714-treated mice made fewer errors than other groups, suggesting a better learning. In the fear conditioning, B. longum 1714-treated group also showed better learning and memory, yet presenting the same extinction learning profile as controls. None of the treatments affected visceral sensitivity. Altogether, these data suggest that B. longum 1714 had a positive impact on cognition and also that the effects of individual Bifidobacteria strains do not generalise across the species. Clinical validation of the effects of probiotics on cognition is now warranted. © 2015 Elsevier B.V. Source


Savignac H.M.,Alimentary Pharmabiotic Center | Kiely B.,Alimentary Health Ltd. | Dinan T.G.,University College Cork | Cryan J.F.,University College Cork
Neurogastroenterology and Motility | Year: 2014

Background: Accumulating evidence suggests that commensal bacteria consumption has the potential to have a positive impact on stress-related psychiatric disorders. However, the specific bacteria influencing behaviors related to anxiety and depression remain unclear. To this end, we compared the effects of two different Bifidobacteria on anxiety and depression-like behavior; an antidepressant was also used as a comparator. Methods: Innately anxious BALB/c mice received daily Bifidobacterium longum (B.) 1714, B. breve 1205, the antidepressant escitalopram or vehicle treatment for 6 weeks. Behavior was assessed in stress-induced hyperthermia test, marble burying, elevated plus maze, open field, tail suspension test, and forced swim test. Physiological responses to acute stress were also assessed. Key Results: Both Bifidobacteria and escitalopram reduced anxiety in the marble burying test; however, only B. longum 1714 decreased stress-induced hyperthermia. B. breve 1205 induced lower anxiety in the elevated plus maze whereas B. longum 1714 induced antidepressant-like behavior in the tail suspension test. However, there was no difference in corticosterone levels between groups. Conclusions & Inferences: These data show that these two Bifidobacteria strains reduced anxiety in an anxious mouse strain. These results also suggest that each bacterial strain has intrinsic effects and may be beneficially specific for a given disorder. These findings strengthen the role of gut microbiota supplementation as psychobiotic-based strategies for stress-related brain-gut axis disorders, opening new avenues in the field of neurogastroenterology. © 2014 John Wiley & Sons Ltd. Source


Patent
ALIMENTARY HEALTH Ltd | Date: 2014-03-18

Probiotic


Patent
The Iams Company and ALIMENTARY HEALTH Ltd | Date: 2014-10-17

According to the present invention there are provided methods of use in companion animals of probiotic bacteria of the genus


Patent
Alimentary Health Ltd, Procter and Gamble | Date: 2013-01-10

An isolated polysaccharide has the structure [-(1,3)-D-GaIpNAc-(1,4)-D-Glcp-]

Discover hidden collaborations