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Atici T.,Uludag University | Sahin N.,Ali Osman Sonmez Oncology Hospital | Ozturk A.,Yuksek Ihtisas Research Hospital | Yaray O.,Uludag University
Ulusal Travma ve Acil Cerrahi Dergisi | Year: 2010

Background We evaluated the results of intertrochanteric hip fractures treated with closed reduction and external fixation (minimally invasive and biological osteosynthesis) in patients with high surgical risk. Methods Twenty-three patients (14 females, 9 males; mean age 74 [65-88]) with intertrochanteric hip fracture classified as group III and IV according to American Society of Anesthesiologists (ASA) criteria were treated with closed reduction and unilateral external fixation under short-term anesthesia. Fourteen fractures were stable (60.8%) and nine were unstable (39.2%). The mean follow-up was 23.8 months (4-58). We evaluated the operation time, hospitalization time, union time, mobilization capacity, complications, and mortality rates. Results The mean duration of operation was 25 minutes (15-40), mean duration of hospital stay 4 days (2-9) and average union time 13 weeks. Five patients (21.7%) died due to additional health problems in the first six months after surgery. Superficial pin tract infection occurred in 11 cases (47.8%). There was no implant failure. In the last follow up, an average 5° varus (range: 0-8°) and 1 cm shortening (range: 0-3) in stable fractures and an average 15° varus (range: 8-20°) and 3 cm shortening (range: 2-5) in unstable fractures were determined. Conclusion The treatment of intertrochanteric hip fractures with closed reduction and external fixation is an easy, effective and safe biological fixation method with minimal damage to surrounding tissues, especially in patients with high surgical risk. Source

Yilmaz I.,Bozyaka Training and Research Hospital | Yonguc N.G.,Izmir University | Tosun S.,Ali Osman Sonmez Oncology Hospital | Kayir H.,Gulhane Medical School | Uzbay T.,Istanbul University
Journal of Neurological Sciences | Year: 2014

Objective: Audiogenic seizure (AS) susceptibility is observed following withdrawal from chronic ethanol treatment in rodents. This is the first study to investigate and compare the effects of ethanol withdrawal on the hippocampal formation in AS appeared and nonappeared animals.Material and Methods: Adult male Wistar rats (225-320 g) were used. Ethanol was given to rats in a modified liquid diet for twenty days. Daily ethanol consumption was in a range of 10.35±1.25 to 15.20±0.79 g/kg during the exposure to ethanol (7.2%). At the end of exposure to a 7.2% ethanol-containing liquid diet, ethanol was withdrawn and withdrawal signs were recorded or rated. Increased stereotyped behavior, wet dog shakes, agitation, tail-stiffness and abnormal posture and gait appeared during ethanol withdrawal in dependent rats. AS was also induced in 5 of 11 of ethanol dependent rats. Following audiogenic stimuli, rats were decapitated and their brains were removed. Neuron counts from pyramidal cell layers in CA1 and CA2-3 regions of the hippocampus were obtained from control rats and ethanoldependent rats with and without audiogenic seizure.Results: Significant neuronal losses were found in CA1 and CA2-3 regions of the hippocampal formation in the ethanol-dependent group. Neuronal loses in AS appeared group were significantly more than in AS non-appeared group.Conclusions: ASs during ethanol withdrawal significantly potentiated neuronal degeneration in all subdivisions of the CA area of the hippocampal formation in rats. Thus, prevention of seizures in alcoholic individuals may be important for protection from excessive neuronal damage in the hippocampus. © 2014, Ege University Press. All rights reserved. Source

Cirak Y.,Bahcesehir University | Furuncuoglu Y.,Bahcesehir University | Yapicier O.,Acibadem University | Aksu A.,Firat University | Cubukcu E.,Ali Osman Sonmez Oncology Hospital
Journal of B.U.ON. | Year: 2015

Purpose: The aim of this study was to determine the expression level of Aurora A in human breast cancer tissues and to test whether there is a relationship between its expression levels and clinicopathological parameters including response to taxanes, tumor grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, and overall survival (OS). Methods: We retrospectively analyzed paraffin-embedded tissue sections from 49 metastatic breast cancer patients whose clinical outcomes had been tracked after taxane treatment. The expression status of Aurora A was defined by immunohistochemistry (IHC) using the anti-Aurora A antibody. Results: Aurora A was overexpressed in 73% of the examined specimens. There was significant correlation between high Aurora A expression and decreased taxane sensitivity (p=0.02). There was no association between the clinicopathological parameters including histologic grade, ER positivity and triple negative molecular subtype and the level of Aurora A expression. However, HER2 positive tumors showed significantly higher Aurora-A expression compared with HER2 negative tumors (p=0.02). Kaplan-Meier survival analysis failed to show a significant correlation between expression levels of Aurora A and OS although patients with low Aurora A levels had a marginally longer survival compared to patients with high levels. Conclusion: Our data suggest that Aurora A may be a promising predictive and prognostic marker in patients with breast cancer. Source

Avci N.,Uludag University | Deligonul A.,Uludag University | Tolunay S.,Uludag University | Cubukcu E.,Uludag University | And 5 more authors.
Journal of B.U.ON. | Year: 2015

Purpose: The impact of neoadjuvant chemotherapy (NACT) on immunohistochemical markers in breast cancer specimens remains controversial We designed the current study to investigate the potential changes in estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki-67 expression before and after NACT in a cohort of Turkish patients with breast cancer. Methods: This research was designed as a prospective, observational study of 100 consecutive patients with breast cancer (mean age 47.8±11.4 years) who were scheduled to undergo anthracycline- And/or taxane-containing NACT before attempting cytoreductive surgery at the Department of Oncology of the Uludag University Medical Center, Bursa, Turkey. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded specimens. Results: Changes in immunohistochemical markers before and after NACT were only significant for HER-2 and Ki- 67. More specifically, the number of HER-2-positive specimens decreased from 21 before NACT to 8 after NACT (p<0.001). Similarly, the number of tumor samples positive for Ki-67 decreased significantly from 65 to 24 after NACT (p <0.001). Mean pre- And post-treatment tumor grades of differentiation before and after NACT were 2.56 ± 0.67 and 237±1.07, respectively (p<0.05). We did not find any significant associations between baseline ER, PR, HER2, and Ki-67 expression with both overall survival (OS) and dis- ease-free survival (DFS). Conclusion: Our study suggests that NACT reduces the expression of HER2 and Ki-67 in breast cancer specimens. The significance of NACT-induced changes in the immunohistochemical expression of HER2 and Ki-67 in patients with breast cancer should be further studied in future translational and clinical research. Source

Tos T.,SAMI Health | Alp M.Y.,Ali Osman Sonmez Oncology Hospital | Aksoy A.,SAMI Health | Ceylaner S.,Lntergen Genetics Center | Uer A.H.A.M.,University of Strasbourg
Genetic Counseling | Year: 2015

A familial case of Coffin-Lowry syndrome caused by RPS6KA3 c.898C>T mutation associated with multiple abnormal brain imaging findings: Coffin-Lowry syndrome (CLS) is a rare X linked mental retardation syndrome characterised by severe psychomotor and growth retardation, distinct facial phenotype, and progressive skeletal malformations. It is caused by mutations in the RPS6KA3 gene located at Xp22.2. In this report we describe a family with CLS consists of three affected males, and two affected females, arising from c.898C>T mutation in RPS6KA3 gene. A 6 year-old, and a 3 year-old boy both had distinct clinical features of Coffin-Lowry syndrome; severe mental and motor retardation, microcephaly, prominent forehead, hypertelorism, large mouth, large ears, large soft hands, puffy tapered fingers, and pectus carinatum. In addition, they had multiple abnormal brain MRI findings. Other siblings presented with a mild and variable phenotype. Source

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