Riyadh, Saudi Arabia

Alfaisal University

Riyadh, Saudi Arabia

Alfaisal University is a private, non-profit, research university located in Riyadh, Saudi Arabia. It is the second co-educational university in Saudi Arabia after KAUST. It commenced its academic programs in 2007.The university was founded by a consortium of King Faisal Foundation, Harvard, MIT, Cambridge, ISU, King Faisal Specialist Hospital, KACST, MODON, Thales, Saudi Aramco and Boeing. Wikipedia.

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Alfaisal University | Date: 2015-09-12

There is provided a method of detecting an analyte in a sample. The method is based on colorimetry and also on the binding affinity between the analyte and a chemical substrate which may be a recognition receptor thereof. The method involves a support and a colored carrier. A kit for use in the detection is also provided.

Alfaisal University | Date: 2015-09-28

There is provided a biosensor for detecting pathogens in a sample. The detection is based on colorimetry. The biosensor comprises one or more particle supports and a magnetic material attached to a planar support. The biosensor embodies magnetic particles that are functionalized using a chemical substrate specific to the pathogens to be detected. The sensor may allow for a simultaneous detection of a plurality of pathogens in the sample. Also, the sensor may be disposable. Moreover, the sensor may be integrated in a portable detection device.

A multiplex hand-held diagnostic biosensor, using two inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was constructed made to potentially detect Periodontitis at an early stage is described. The use of magnetic nanoparticle biosensor method used as a device was based on the measurement of proteolytic activity using specific proteases probes. The magnetic nanoparticle biosensor device is capable of specific and quantitative detection of HNE and Cathepsin-G in solution and in spiked saliva samples with a lower detection limit of 1 pg/mL and 100 fg/mL for HNE and Cathepsin-G, respectively.

A facile approach is described to prepare monodisperse Fe_(3)O_(4 )and Co_(3)O_(4 )nanoparticles on chemically reduced graphene oxide (rGO) to form nanocomposites by low temperature solution route and MWI method, respectively. These processes are environmentally friendly and convenient compared with previously reported methods. The synthesized nanocomposites were characterized using x-ray diffraction spectroscopy (XRD), raman spectroscopy, scanning electron microscopy (SEM) measurements and UV/Vis absorption spectroscopy. XRD patterns revealed the high crystalline quality of the nanocomposites. SEM micrographs showed the morphology of the rGO nanosheets decorated by Co_(3)O_(4 )and Fe_(3)O_(4 )nanoparticles. UV/Vis study revealed the formation of Fe_(3)O_(4)/rGO and Co_(3)O_(4)/rGO nanocomposites with characteristics absorption maxima. Finally, preliminary results of using the Fe_(3)O_(4)/rGO and Co_(3)O_(4)/rGO composites for efficient killing of Human hepatocytes cancer (HepG_(2)) cell are reported. Nanocomposites produced by MWI showed better anticancer activity and higher yield than that of low temperature solution route.

Alkuraya F.S.,King Faisal Specialist Hospital And Research Center | Alkuraya F.S.,Alfaisal University
Trends in Genetics | Year: 2015

Although numerous approaches have been pursued to understand the function of human genes, Mendelian genetics has by far provided the most compelling and medically actionable dataset. Biallelic loss-of-function (LOF) mutations are observed in the majority of autosomal recessive Mendelian disorders, representing natural human knockouts and offering a unique opportunity to study the physiological and developmental context of these genes. The restriction of such context to 'disease' states is artificial, however, and the recent ability to survey entire human genomes for biallelic LOF mutations has revealed a surprising landscape of knockout events in 'healthy' individuals, sparking interest in their role in phenotypic diversity beyond disease causation. As I discuss in this review, the potentially wide implications of human knockout research warrant increased investment and multidisciplinary collaborations to overcome existing challenges and reap its benefits. © 2014 Elsevier Ltd.

Alkuraya F.S.,King Faisal Specialist Hospital And Research Center | Alkuraya F.S.,Alfaisal University
Human Genetics | Year: 2013

Autozygosity, or the inheritance of two copies of an ancestral allele, has the potential to not only reveal phenotypes caused by biallelic mutations in autosomal recessive genes, but to also facilitate the mapping of such mutations by flagging the surrounding haplotypes as tractable runs of homozygosity (ROH), a process known as autozygosity mapping. Since SNPs replaced microsatellites as markers for the purpose of genomewide identification of ROH, autozygosity mapping of Mendelian genes has witnessed a significant acceleration. Historically, successful mapping traditionally required favorable family structure that permits the identification of an autozygous interval that is amenable to candidate gene selection and confirmation by Sanger sequencing. This requirement presented a major bottleneck that hindered the utilization of simplex cases and many multiplex families with autosomal recessive phenotypes. However, the advent of next-generation sequencing that enables massively parallel sequencing of DNA has largely bypassed this bottleneck and thus ushered in an era of unprecedented pace of Mendelian disease gene discovery. The ability to identify a single causal mutation among a massive number of variants that are uncovered by next-generation sequencing can be challenging, but applying autozygosity as a filter can greatly enhance the enrichment process and its throughput. This review will discuss the power of combining the best of both techniques in the mapping of recessive disease genes and offer some tips to troubleshoot potential limitations. © 2013 Springer-Verlag Berlin Heidelberg.

Kvietys P.R.,Alfaisal University | Granger D.N.,Louisiana State University Health Sciences Center
Free Radical Biology and Medicine | Year: 2012

Inflammation is a complex and potentially life-threatening condition that involves the participation of a variety of chemical mediators, signaling pathways, and cell types. The microcirculation, which is critical for the initiation and perpetuation of an inflammatory response, exhibits several characteristic functional and structural changes in response to inflammation. These include vasomotor dysfunction (impaired vessel dilation and constriction), the adhesion and transendothelial migration of leukocytes, endothelial barrier dysfunction (increased vascular permeability), blood vessel proliferation (angiogenesis), and enhanced thrombus formation. These diverse responses of the microvasculature largely reflect the endothelial cell dysfunction that accompanies inflammation and the central role of these cells in modulating processes as varied as blood flow regulation, angiogenesis, and thrombogenesis. The importance of endothelial cells in inflammation-induced vascular dysfunction is also predicated on the ability of these cells to produce and respond to reactive oxygen and nitrogen species. Inflammation seems to upset the balance between nitric oxide and superoxide within (and surrounding) endothelial cells, which is necessary for normal vessel function. This review is focused on defining the molecular targets in the vessel wall that interact with reactive oxygen species and nitric oxide to produce the characteristic functional and structural changes that occur in response to inflammation. This analysis of the literature is consistent with the view that reactive oxygen and nitrogen species contribute significantly to the diverse vascular responses in inflammation and supports efforts that are directed at targeting these highly reactive species to maintain normal vascular health in pathological conditions that are associated with acute or chronic inflammation. © 2011 Elsevier Inc. © 2011 Elsevier Inc. All rights reserved.

Al-Tawfiq J.A.,Aramco Services Company | Memish Z.A.,Alfaisal University
Eurosurveillance | Year: 2012

This year the Hajj will take place during 24-29 October. Recent outbreaks of Ebola haemorrhagic fever in Uganda and the Democratic Republic of the Congo, cholera in Sierra Leone, and infections associated with a novel coronavirus in Saudi Arabia and Qatar required review of the health recommendations of the 2012 Hajj. Current guidelines foresee mandatory vaccination with quadrivalent meningococcal vaccine for all pilgrims, and yellow fever and poliomyelitis vaccine for pilgrims from high-risk countries. Influenza vaccine is strongly recommended.

Alfaisal University | Date: 2014-02-16

The copolymer of styrene and methylmethacrylate containing reduced graphene oxide/silver nanoparticles (PS-PMMA/RGO/AgNPs) nanocomposite were prepared via in situ bulk polymerization method using two different preparation techniques. In the first approach, a mixture of graphene oxide (GO), styrene (S) and methylmethacrylate monomers (MMA) were polymerized using a bulk polymerization method with a free radical initiator. After the addition silver nitrate (AgNO_(3)), the product was reduced via microwave irradiation (MWI) in presence of the reducing agent hydrazine hydrate (HH), to obtain R-(GO-(PS-PMMA))/AgNPs nanocomposite. This nanocomposite was then used to create a material that had antimicrobial properties to be used in medical devices or medical related implants.

Alfaisal University | Date: 2013-09-04

A novel nanocomposite having graphene sheets is described. The nanocomposite may be used for medical devices such as bone cement, dentures, paper, paint and automotive industries. A novel Microwave irradiation (MWI) was used to obtain R-(GO-(STY-co-MMA)). The results indicate that the nanocomposite obtained using the MWI had a better morphology and dispersion with enhanced thermal stability compared with the nanocomposite prepared without MWI. An average increase of 136% in hardness and 76% in elastic modulus were achieved through the addition of only 2.0 wt % of RGO nanocomposite obtained via the MWI method.

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