Cheshire, CT, United States
Cheshire, CT, United States

Alexion Pharmaceuticals is the original developer and distributor of Soliris, a drug used to treat the rare disorders atypical hemolytic uremic syndrome and Paroxysmal nocturnal hemoglobinuria .The company is also involved in research with regards to the immune system and how it can be stopped from attacking healthy tissue .Soliris, the company's sole marketed drug, has been approved for use in the EU and Japan however availability in other places such as the USA and Canada is limited due to marketing restrictions and lack of ensured access .In 2013 36% of sales originated in the US down from 37%, with 33% coming from Europe down from 35%; Japan accounts for just over 10%. In 2013 revenue was impacted by higher unit volumes for Soliris , and a negative price impact related to rebates in Europe; acquisition related costs fell significantly from $22 million to just $5 million. In 2011 50% of the increase in assets came from cash and cash equivalents, the value of which has since gone down since part of it was spent on acquiring Enobia. In the last quarter, R&D spending was higher due to expansion of development programs while net sales of Soliris increased 45% to $227.6 million on account of new international patients with paroxysmal nocturnal hemoglobinuria. By September 2013 quarterly sales of Soliris topped $400 million. Wikipedia.


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Patent
Alexion Pharmaceuticals | Date: 2016-09-09

The present disclosure relates to, inter alia, a recombinant eculizumab protein or a recombinant eculizumab variant protein having specific glycosylation patterns. The present disclosure relates to, inter alia, a recombinant eculizumab protein or a recombinant eculizumab variant protein made from CHO cells. The present disclosure also relates to methods for the use of these proteins.


Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial in a small cohort of patients with paroxysmal nocturnal hemoglobinuria (PNH). The present study examined whether chronic eculizumab therapy could reduce intravascular hemolysis, stabilize hemoglobin levels, reduce transfusion requirements, and improve quality of life in a double-blind, randomized, placebo-controlled, multi-center global Phase III trial. It has been found that eculizumab stabilized hemoglobin levels, decreased the need for transfusions, and improved quality of life in PNH patients via reduced intravascular hemolysis. Chronic eculizumab treatment appears to be a safe and effective therapy for PNH.


Patent
Alexion Pharmaceuticals | Date: 2017-01-25

The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the composition contain an antibody, or antigen-binding thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.


Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial in a small cohort of patients with paroxysmal nocturnal hemoglobinuria (PNH). The present study examined whether chronic eculizumab therapy could reduce intravascular hemolysis, stabilize hemoglobin levels, reduce transfusion requirements, and improve quality of life in a double-blind, randomized, placebo-controlled, multi-center global Phase III trial. It has been found that eculizumab stabilized hemoglobin levels, decreased the need for transfusions, and improved quality of life in PNH patients via reduced intravascular hemolysis. Chronic eculizumab treatment appears to be a safe and effective therapy for PNH.


Patent
Alexion Pharmaceuticals | Date: 2016-09-12

The present disclosure relates to, inter alia, antibodies, or antigen-binding fragments thereof, that bind to C5a and to use of the antibodies in methods for treating or preventing complement-associated disorders such as, but not limited to, atypical hemolytic uremic syndrome, age-related macular degeneration, rheumatoid arthritis, sepsis, severe burn, antiphospho lipid syndrome, asthma, lupus nephritis, Goodpastures syndrome, and chronic obstructive pulmonary disease.


Patent
Alexion Pharmaceuticals | Date: 2016-08-22

The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.


Patent
Alexion Pharmaceuticals | Date: 2016-08-22

The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.


Patent
Alexion Pharmaceuticals | Date: 2016-06-14

A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.


Patent
Alexion Pharmaceuticals | Date: 2016-11-23

The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9 TCC) and C5a anaphylatoxin-mediated inflammation and, thus, treating complement-associated disorders. The antibodies have a number of improved properties relative to eculizumab, including, e.g., increased serum half-life in a human.


Patent
Alexion Pharmaceuticals | Date: 2016-08-17

An antibody specific to C5, which inhibits the cleavage of C5, for use in prolonging survival of an allograft in a recipient mammal, wherein said antibody to C5 is to be administered chronically and said antibody to C5 is administered in conjunction with more than one immunosuppressive drug.

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