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Alexandria, Egypt

Alexandria University is a public research university in Alexandria, Egypt. It was established in 1938 as a satellite of Fuad University , becoming an independent entity in 1942. It was known as Farouk University until the Egyptian Revolution of 1952 when its name was changed to the University of Alexandria. Taha Hussein was the founding rector of Alexandria University. It is now the second largest university in Egypt and has many affiliations to various universities for ongoing research. Wikipedia.


BACKGROUND: The modified Karydakis flap and the modified Limberg flap are commonly used in the surgical management of sacrococcygeal pilonidal sinus disease. OBJECTIVE: The study aimed to compare short- term results of these techniques. DESIGN: The modified Karydakis flap and the modified Limberg flap were compared in a randomized controlled trial. SETTINGS: The study was conducted in the day-case surgery department of a large academic teaching hospital in Alexandria, Egypt, from February 2009 through September 2011. PATIENTS: Patients undergoing surgery for chronic sacrococcygeal pilonidal sinus disease were eligible for the study. Patients with sepsis were eligible only after aggressive treatment to eliminate sepsis. INTERVENTIONS: Patients were randomly allocated to undergo surgery with either the modified Karydakis flap or the modified Limberg flap. MAIN OUTCOME MEASURES: The primary end point was operative time. Secondary endpoints included proportion of patients with postoperative complications, proportion of patients who were satisfied with the cosmetic results, and the rate of recurrence. LIMITATIONS: Follow-up times were not sufficient to evaluate long-term recurrence rates. RESULTS: Of 154 patients screened, 125 were enrolled, and 120 patients completed the study. The median operative time was significantly shorter in patients with the modified Karydakis flap than in those with the modified Limberg flap: 33 (range, 28-40) min vs 52 (range, 48-62) min; p < 0.001). No significant differences were found between study groups regarding overall complication rate (23% vs 40%, p = 0.08), wound infection (3% vs 5%, p > 0.99), subcutaneous fluid collection (5% vs 0%, p = 0.24), or hypoesthesia (10% vs 23%, p = 0.09). Full-thickness wound disruption was encountered in 9 patients (15%) in the modified Limberg group vs no patient in the modified Karydakis group (p = 0.003). The median follow-up duration was 20.5 months in each study group. One patient (2%) in the modified Karydakis group developed recurrent disease vs 2 patients (3%) in the modified Limberg group (p > 0.99). In the modified Karydakis group, 58 patients (97%) were satisfied with the cosmetic outcome and were willing to recommend the operation to others vs 43 patients (72%) in the modified Limberg group (p < 0.001). CONCLUSIONS: Both techniques provide effective treatment for pilonidal sinus disease and can be performed safely as day-case surgery. The modified Karydakis flap is associated with significantly shorter operative time, a lower full-thickness wound disruption rate, and a higher patient satisfaction rate. © The ASCRS 2013. Source


Objective: To learn the incidence of erectile dysfunction (ED) after pelvic fracture urethral injury (PFUI) and to identify the related risk factors. Methods: Patients who had sustained a PFUI from 1984 to 2010 were identified from database and invited to participate in the study. All responders were queried after a minimum of 2 years from the time of trauma to assess their erectile function (EF) using the EF domain of the International Index of Erectile Function (IIEF). Medical records and imaging studies were reviewed with a focus on 6 variables that may predict ED. Univariate and multivariate analyses were used to identify parameters predictive of ED. Results: Overall, 90 patients participated in the study, among whom 40 (44%) had ED. On univariate analysis, 4 variables were significant factors for prediction of ED, whereas on multivariate analysis only 3 factors remained strong and independent predictors, namely diastasis of pubic symphysis, lateral displacement of prostate, and long urethral gap. The results of analyses showed that these 3 variables were significant at odds ratios (ORs) of 15.9, 6.9, and 2.0, respectively. Conclusion: The development of ED after PFUI can be predicted by 3 factors, namely diastasis of pubic symphysis, lateral prostatic displacement, and long urethral gap. Pubic diastasis has the highest predictive accuracy. A tendency for higher risk of ED could be observed after bilateral rami and Malgaigne's fractures, but they failed to reach the level of significant predictors on multivariate analysis. No relationship was evidenced between ED and age at traumatism. © 2013 Elsevier Inc. All Rights Reserved. Source


Bahey-El-Din M.,Alexandria University
Vaccine | Year: 2012

Developing effective vaccines is an important weapon in the battle against potential pathogens and their evolving antibiotic resistance trends. Several vaccine delivery vectors have been investigated among which the generally regarded as safe (GRAS) Lactococcus lactis has a distinguished position. In this review, different factors affecting the efficacy of L. lactis-based vaccines are discussed. In addition, the issues of biological containment and pharmaceutical quality assurance of L. lactis vaccines are highlighted. These issues are critical for the success of medical translation of L. lactis-based vaccines from research laboratories to clinical use by ensuring consistent manufacturing of safe and efficacious vaccines. © 2011 Elsevier Ltd. Source


Oxidative stress by increased production of reactive oxygen species has been implicated in the toxicity of many pesticides. Therefore, the aim of the present study was to investigate the effect of a broad spectrum insecticide, composed of a mixture of organophosphate plus pyrethroids (fenitrothion 25%, lambda cyhalothrin 2.5% and piperonyl butoxide 6%), on antioxidant status and oxidative stress biomarkers in rat brain. Different insecticide concentrations (0, 0.1, 1, 10, 100 and 1000. mM) were incubated with brain homogenate at 37°C for time intervals (0, 30, 60, 120, 180 and 240. min). Exposure to insecticide mixture resulted in a significant increase (p<0.05) in thiobarbituric acid reactive substances (TBARS), which might be associated with decreased levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and acetylcholinesterase activities and beside protein content in rat brain. However, a significant induction of lactate dehydrogenase (LDH) activities was observed. The response was concentration and time dependent. Results showed that the used insecticides had the propensity to cause significant oxidative damage in rat brain, which is associated with marked perturbations in antioxidant defense system in addition to antioxidant enzymes can be used as potential biomarkers of toxicity associated with pesticides exposure. © 2011 Elsevier Ltd. Source


Koraitim M.M.,Alexandria University
Journal of Urology | Year: 2014

Purpose We sought to determine the incidence of erectile dysfunction following pelvic fracture urethral injuries in children, and to identify the related causes and risk factors. Materials and Methods All consecutive children who had undergone repair of a pelvic fracture urethral injury between 1980 and 2010 were invited to participate in the study. All responders were queried after a median of 13 years (range 3 to 28) following trauma to assess erectile function using the erectile function domain of the International Index of Erectile Function. Patients who had erectile dysfunction underwent penile duplex ultrasonography. Medical records and imaging studies were reviewed with a focus on 4 variables, ie pattern of pelvic fracture, pubic diastasis, prostatic displacement and urethral gap length. Univariate and multivariate analyses were used to identify parameters predictive of erectile dysfunction at puberty. Results A total of 60 patients participated in the study, of whom 28 (47%) had erectile dysfunction. On univariate analysis all 4 parameters were significant predictors of erectile dysfunction, while on multivariate analysis only 2 parameters remained strong and independent predictors, namely urethral gap length 2.5 cm or greater and prostatic displacement in a lateral direction. Duplex ultrasound revealed the cause of erectile dysfunction as arteriogenic in 19 patients (76%), arteriovenogenic in 2 (8%) and likely neurogenic in 4 (16%). Conclusions For every 2 children sustaining a pelvic fracture urethral injury 1 will exhibit erectile dysfunction at puberty. The risk of erectile dysfunction is appreciably increased in the presence of a long urethral gap and/or lateral prostatic displacement. The cause of erectile dysfunction is most commonly primarily arteriogenic and less commonly neurogenic. © 2014 by American Urological Association Education and Research, Inc. Source

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