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Alderson, WV, United States

Hunter K.M.,Alderson Broaddus College
Online Journal of Nursing Informatics | Year: 2011

Technology designed to facilitate the medication administration process in healthcare facilities promises to reduce medication errors. This article describes one hospital's journey on the road to medication safety. © 2011 OJNI. Source

Gao Y.,Zhejiang University | Li W.,Zhejiang University | Jia L.,Zhejiang University | Li B.,Alderson Broaddus College | And 2 more authors.
Biochemical and Biophysical Research Communications | Year: 2013

Tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and theaflavin-3-3'-digallate (TF3) are two prospective compounds in cancer prevention and treatment. Ascorbic acid (Vc) is essential to a healthy diet as well as being a highly effective antioxidant. In this work, the effects of the combination of EGCG or TF3 with Vc on the apoptosis and caspases-3/9 activities in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells were determined. Furthermore, the role of mitogen-activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three MAPK inhibitors (ERK inhibitor PD98059, JNK inhibitor SP600125 and p38 inhibitor SB203580). Our results showed that Vc could enhance the EGCG and TF3 induced apoptosis in SPC-A-1 and Eca-109 cells, and this effect involved the activation of caspase-3 and 9. EGCG, TF3 and Vc could activate MAPK pathways respectively, and each compound activated different MAPK subfamilies in different cells. This may explain the enhancement of EGCG and TF3 induced apoptosis by Vc in SPC-A-1 and Eca-109 cells, and will ultimately aid the design of more effective anti-cancer treatments. © 2013 Elsevier Inc. Source

Lohcharoenkal W.,West Virginia University | Wang L.,U.S. National Institute for Occupational Safety and Health | Chen Y.C.,Alderson Broaddus College | Rojanasakul Y.,West Virginia University
BioMed Research International | Year: 2014

Nanoparticles have increasingly been used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. A large number of nanoparticle drug delivery systems have been developed for cancer treatment and various materials have been explored as drug delivery agents to improve the therapeutic efficacy and safety of anticancer drugs. Natural biomolecules such as proteins are an attractive alternative to synthetic polymers which are commonly used in drug formulations because of their safety. In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability. They can be prepared under mild conditions without the use of toxic chemicals or organic solvents. Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation. Finally, we discuss the applications of protein nanoparticles in cancer therapy. © 2014 Warangkana Lohcharoenkal et al. Source

Zegre N.P.,West Virginia University | Miller A.J.,West Virginia University | Maxwell A.,Alderson Broaddus College | Lamont S.J.,Natural Resources Analysis Center
Journal of the American Water Resources Association | Year: 2014

In the Appalachian region of the eastern United States, mountaintop removal mining (MTM) is a dominant driver of land-cover change, impacting 6.8% of the largely forested 4.86 million ha coal fields region. Recent catastrophic flooding and documented biological impairment downstream of MTM has drawn sharp criticism to this practice. Despite its extent, scale, and use since the 1970s, the impact of MTM on hydrology is poorly understood. Therefore, the goal of this study was a multiscale evaluation to establish the nature of hydrologic impacts associated with MTM. To quantify the extent of MTM, land-cover change over the lifetime of this practice is estimated for a mesoscale watershed in southern West Virginia. To assess hydrologic impacts, we conducted long-term trend analyses to evaluate for systematic changes in hydrology at the mesoscale, and conducted hydrometric and response time modeling to characterize storm-scale responses of a MTM-impacted headwater catchment. Results show a general trend in the conversion of forests to mines, and significant decreases in maximum streamflow and variability, and increases in base-flow ratio attributed to valley fills and deep mine drainage. Decreases in variability are shown across spatial and temporal scales having important implications for water quantity and quality. However, considerable research is necessary to understand how MTM impacts hydrology. In an effort to inform future research, we identify existing knowledge gaps and limitations of our study. © 2014 American Water Resources Association. Source

Chen A.Y.,West Virginia University | Chen Y.C.,Alderson Broaddus College
Food Chemistry | Year: 2013

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferol may help by augmenting the body's antioxidant defence against free radicals, which promote the development of cancer. At the molecular level, kaempferol has been reported to modulate a number of key elements in cellular signal transduction pathways linked to apoptosis, angiogenesis, inflammation, and metastasis. Significantly, kaempferol inhibits cancer cell growth and angiogenesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aim of this review is to synthesize information concerning the extraction of kaempferol, as well as to provide insights into the molecular basis of its potential chemo-preventative activities, with an emphasis on its ability to control intracellular signaling cascades that regulate the aforementioned processes. Chemoprevention using nanotechnology to improve the bioavailability of kaempferol is also discussed. © 2012 Elsevier Ltd. All rights reserved. Source

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