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Aalborg, Denmark

Skaaby T.,Glostrup University Hospital | Husemoen L.L.N.,Glostrup University Hospital | Thuesen B.H.,Glostrup University Hospital | Pisinger C.,Glostrup University Hospital | And 7 more authors.
Cancer Epidemiology Biomarkers and Prevention | Year: 2014

Background: Observational studies have suggested an inverse association between vitamin D status and cancer.Weinvestigated the prospective associations between vitaminDstatus and the total and specific type of cancer in three cohorts from the general Danish population. Methods: A total of 12,204 individuals 18 to 71 years old were included. The level of 25-hydroxyvitamin D was measured at baseline, and information about cancer was obtained from the Danish Cancer Registry. Results: During the 11.3-year median follow-up time, there were 1,248 incident cancers.HRs [95%confidence intervals (CI)] per 10nmol/L higher baseline vitaminDlevel were: for all cancers (HR=1.02; 95%CI, 0.99-1.04), all cancers excluding non-melanoma skin cancer, NMSC (HR = 1.00; 95% CI, 0.97-1.03), head and neck cancer (HR = 0.97; 95% CI, 0.84-1.12), colorectal cancer (HR = 0.95; 95% CI, 0.88-1.02), cancer of bronchus and lung (HR= 0.98; 95%CI, 0.91-1.05), breast cancer (HR= 1.02; 95%CI, 0.96-1.09), cancer of the uterus (HR= 1.10; 95% CI, 0.95-1.27), prostate cancer (HR = 1.00; 95% CI, 0.93-1.08), cancer of the urinary organs (HR = 1.01; 95% CI, 0.90-1.14), NMSC (HR = 1.06; 95% CI, 1.02-1.10), and malignant melanoma (HR = 1.06; 95% CI, 0.95-1.17). Conclusions: Apart from a significantly higher risk for NMSC with higher vitamin D status, we found no statistically significant associations between vitamin D status and total or specific cancers. Impact: Our results do not indicate that there is an impact of vitamin D on total cancer incidence. © 2014 American Association for Cancer Research.

Kanthe A.M.,University of Zagreb | Simunic D.,University of Zagreb | Prasad R.,Alborg University
2012 IEEE International Conference on Computational Intelligence and Computing Research, ICCIC 2012 | Year: 2012

The mobile ad-hoc networks (MANET) are an emerging research area with applications. It has features like working as a router, dynamic topology and autonomous. In MANET, nodes have limited resources like battery power, storage space and bandwidth. There is a need to do more research for Denial of Service (DoS) attacks in MANET as compared to wire line DoS attacks. MANET is vulnerable to different types of DoS attack in which packets are drop. Black hole attack, packet drop attack and gray hole attack are an event that eliminates a network's capacity to perform its expected function. These attacks are type of DoS attack which we examine in this paper. This paper shows the effects of black hole attack, packet drop attack and gray hole attack on AODV protocol under different performance metrics throughput, packet drop rate and end-to-end delay. The simulation is done in Network Simulator (NS) 2. © 2012 IEEE.

Skaaby T.,Research Center for Prevention and Health | Husemoen L.L.N.,Research Center for Prevention and Health | Borglykke A.,Research Center for Prevention and Health | Jorgensen T.,Research Center for Prevention and Health | And 6 more authors.
Endocrine | Year: 2014

Vitamin D deficiency is common among patients with liver diseases. Both cholestatic and non-cholestatic liver diseases can cause vitamin D deficiency. Whether vitamin D status can also affect liver function is poorly understood. To investigate the association between vitamin D status, liver enzymes, and incident liver disease, we included a total of 2,649 individuals from the Monica10 study conducted in 1993-1994. Vitamin D status as assessed by serum 25-hydroxyvitamin, serum alanine transaminase (ALT), aspartate transaminase (AST), and gamma glutamyl transferase (GGT) were measured at baseline. Information on fatal and non-fatal liver disease was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death, respectively. Median follow-up time was 16.5 years, and there were 62 incident cases of fatal and non-fatal liver disease. Multivariable Cox regression analyses with age as underlying time axis and delayed entry showed a statistically significant inverse association between vitamin D status and incident liver disease with a hazard ratio = 0.88 (95 % confidence interval 0.79-0.99) per 10 nmol/l higher vitamin D status at baseline (adjusted for gender, season, alcohol consumption, smoking, physical activity, dietary habits, education, body mass index, and ALT). The risk of having a high level of ALT, AST, or GGT tended to be higher for lower vitamin D levels, although not statistically significant. In this general population study, vitamin D status was inversely associated with incident liver disease. Further studies are needed to determine whether patients in risk of developing impaired liver function should be screened for vitamin D deficiency for preventive purposes. © 2013 Springer Science+Business Media.

Elmitwally A.,Mansoura University | Elsaid M.,Mansoura University | Elgamal M.,Mansoura University | Chen Z.,Alborg University
IEEE Transactions on Sustainable Energy | Year: 2015

This paper proposes a new multiagent control system (MACS) for service restoration in distribution systems with integrated distributed generation (DG) units. First, the MACS detects and locates faults, then decides the optimal reconfiguration of the network for restoring de-energized loads, and finally regulates the nodes voltages. Unintentional islanding operation of DG units is avoided and different postfault response modes of DG unit are addressed in the MACS design. The MACS has a hybrid centralizeddecentralized structure where agents are arranged in two layers with different responsibilities and communication capabilities. Agents at load buses in the first layer can only communicate directly with its next neighbor load agents on the same feeder and to its feeder agent, whereas the higher level agents in the second layer can communicate directly with each other. This MACS structure reduces the possibilities of control system failures for a moderate communication network infrastructure. Full dynamic simulation model for evaluating the MACS is implemented. © 2010-2012 IEEE.

Skaaby T.,Research Center for Prevention and Health | Husemoen L.L.N.,Research Center for Prevention and Health | Pisinger C.,Research Center for Prevention and Health | Jorgensen T.,Research Center for Prevention and Health | And 5 more authors.
PLoS ONE | Year: 2012

Background: Vitamin D deficiency is associated with an increased risk of all-cause mortality in observational studies. The specific causes of death underlying this association lack clarity. We investigated the association between vitamin D status and cause-specific mortality. Methods: We included a total of 9,146 individuals from the two population-based studies, Monica10 and Inter99, conducted in 1993-94 and 1999-2001, respectively. Vitamin D status was assessed as serum 25-hydroxyvitamin D. Information on causes of death was obtained from The Danish Register of Causes of Death until 31 December 2009. There were a total of 832 deaths (median follow-up 10.3 years). Results: Multivariable Cox regression analyses with age as underlying time axis and vitamin D quartiles showed significant associations between vitamin D status and death caused by diseases of the respiratory system, the digestive system, and endocrine, nutritional and metabolic diseases with hazard ratios (HRs) 0.26 (ptrend = 0.0042), 0.28 (ptrend = 0.0040), and 0.21 (ptrend = 0.035), respectively, for the fourth vitamin D quartile compared to the first. We found non-significantly lower HRs for death caused by mental and behavioural diseases and diseases of the nervous system, but no association between vitamin D status and death caused by neoplasms or diseases of the circulatory system. Conclusion: The associations of vitamin D status and cause-specific mortality suggest that we also look elsewhere (than to cardiovascular disease and cancer) to explain the inverse association between vitamin D status and mortality. © 2012 Skaaby et al.

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