Sundari P.P.,Osmania University |
Mullapudi D.,Albino Research Labs |
Srinivas P.,Albino Research Labs
International Journal of Pharmacy and Technology | Year: 2014
Herbal molecules are known for their potent action and fewer side effects but they have draw backs like low bioavailability, High molecular weight, Low lipophilicity etc. To overcome such drawbacks novel drug delivery systems are employed. One of such an approach is Emulgel. Aim of this work was to formulate an Emulgel of Guggulsterones, Liquorice and Serrapeptidase and investigate their anti-inflammatory and anti-arthritic activity. Formulations were prepared using polymers like Tragacanth, Xanthum gum and Guar gum which are of natural origin. The influence of the gelling agent and its concentration on the drug release from the prepared emulgel was investigated. The prepared Emulgels were evaluated for different parameters and it was concluded that formulations F1, F2, F3 were found to be more promising as it showed desirable physicochemical characteristics. F3 formulation showed better anti inflammatory and anti arthritic activity with 70% inhibition when compared with standard which showed only 62% of inhibition. © 2014, International Journal Of Pharmacy and Technology. All rights reserved.