Albany State University is a four-year, state-supported, historically black university located in Albany, Georgia, United States. It is one of three HBCU's in the University System of Georgia. ASU is a member-school of the Thurgood Marshall College Fund. Wikipedia.
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: STTR | Phase: Phase I | Award Amount: 225.00K | Year: 2015
DESCRIPTION provided by applicant We are pioneering an RNA based switch technology called structurally interacting RNAs sxRNA which utilizes post transcriptional gene regulation as a reporter for miRNA detection Normally RNA binding proteins RBP associate with a andapos stem loop structure to facilitate translation of an upstream coding region by as much as an order of magnitude It is possible to modify the mRNA to modulate translation of the reporter gene by controlling the binding of RBP This is accomplished by creating a trans acting three way junction with an additional RNA such as a miRNA binds and stabilizes the functional structure by base pairing with the flanking regions of the custom designed stem loop Our goal with this proposal is use this selective expression capability to create homogenous populations of cells in culture focusing specifically on stem cells We plan to create a procedure sold as a kit that would eliminate unwanted cells from a differentiated cell population We will accomplish this by using miRNA expression in the desired cells to turn on translation of an antibiotic gene thereby maintaining the desired cells Success with this product development effort will result in a product that has broad appeal to stem cell researchers both for the benefits of increased homogeneity of stem cell cultures and potentially faster development of stem cell related lines and position us to further enhance the technology for use in CHO cells lines for cGMP cell culturing PUBLIC HEALTH RELEVANCE HocusLocus is developing a novel technology to control the expression of an mRNA This technology can be used express an antibiotic resistance gene only in the presence of cells that express a particular miRNA The product being developed will allow stem cell researchers to ensure the homogeneity and potentially speed up culturing of stem cells or differentiated cells by killing unwanted cells based on their miRNA expression patterns
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 224.97K | Year: 2014
DESCRIPTION (provided by applicant): Project Summary/Abstract RNA modifications are numerous, and range from simple methylation to complex changes such as addition of aminoacylcarbamoyl moieties. These modifications and, the levels at which are present, are emerging as important regulators of biological processes, and perturbations such as chemical or drug exposure can alter the patterns of specific modifications on RNA sub-types. Moreover, given their variety, specificity and their relationship to functionand structure stability, RNA modifications are potentially valuable biomarkers of disease and treatment progression, especially given that modified nucleosides are relatively stable even after RNA degradation, and can be released from cells into bodily fluids. The long term objective of this study is to facilitae research into RNA modifications and their impact on health and disease. The immediate hurdle, and the goal of this application, is to develop extremely sensitive analytical methods for detect
Sinha D.,Albany State University |
Lee J.U.,Albany State University
Nano Letters | Year: 2014
The proper understanding of semiconductor devices begins at the metal-semiconductor interface. The metal/semiconductor interface itself can also be an important device, as Schottky junctions often forms when the doping in the semiconductors is low. Here, we extend the analysis of metal-silicon Schottky junctions by using graphene, an atomically thin semimetal. We show that a fundamentally new transport model is needed to describe the graphene-silicon Schottky junction. While the current-voltage behavior follows the celebrated ideal diode behavior, the details of the diode characteristics is best characterized by the Landauer transport formalism, suggesting that the injection rate from graphene ultimately determines the transport properties of this new Schottky junction. © 2014 American Chemical Society.
Yu F.,Albany State University
Journal of Geophysical Research: Atmospheres | Year: 2010
 Nucleation is an important source of atmospheric particles and ubiquitous ions in the atmosphere have long been known to promote nucleation. An ion-mediated nucleation (IMN) mechanism based on a kinetic model is supported by recent measurements of the excess charge on freshly nucleated particles and ion cluster evolution during nucleation events. Here we investigate the dependence of steady state IMN rate (JIMN) on key controlling parameters. We find that sulfuric acid vapor concentration, temperature, relative humidity, ionization rate, and surface area of preexisting particles have profound and nonlinear impacts on JIMN. The sensitivities of JIMN to the changes in these key parameters may imply important physical feedback mechanisms involving climate and emission changes, solar variations, nucleation, aerosol number abundance, and aerosol indirect radiative forcing. We also describe a five-dimensional JIMN look-up table derived from the most recent version of the IMN model, with the key parameters covering a wide range of atmospheric conditions. With the look-up table and a multiple-variable interpolation subroutine, JIMN and the properties of critical clusters can be determined efficiently and accurately under given atmospheric conditions. The look-up table reduces the computational costs of the IMN rate calculations significantly (by a factor of around 8000) and can be readily incorporated into multidimensional models to study the secondary particle formation via IMN and associated climatic and health effects. © Copyright 2010 by the American Geophysical Union.
Torn R.D.,Albany State University
Monthly Weather Review | Year: 2010
An ensemble Kalman filter (EnKF) combined with the Advanced Research Weather Research and Forecasting model (ARW-WRF; hereafter WRF) on a 36-km Atlantic basin domain is cycled over six different time periods that include the 10 tropical cyclones (TCs) selected for the NOAA High-Resolution Hurricane (HRH) test. The analysis ensemble is generated every 6 h by assimilating conventional in situ observations, synoptic dropsondes, and TC advisory position and minimum sea level pressure (SLP) data. On average, observation assimilation leads to smaller TC position errors in the analysis compared to the 6-h forecast; however, the same is true for TC minimum SLP only for tropical depressions and storms. Over the 69 HRH initialization times, TC track forecasts from a single member of the WRF EnKF ensemble has 12 h less skill compared to other operational models; the increased track error partially results from the WRF EnKF analysis having a stronger Atlantic subtropical ridge. For nonmajor TCs, the WRF EnKF forecast has lower TC minimum SLP and maximum wind speed errors compared to some operational models, particularly the GFDL model, while category-3, -4, and -5 TCs are characterized by large biases due to horizontal resolution. WRF forecasts initialized from an EnKF analysis have similar or smaller TC track, intensity, and 34-kt wind radii errors relative to those initialized from two other operational analyses, which suggests that EnKF assimilation produces the best TC forecasts for this domain. Both TC track and intensity forecasts are deficient in ensemble variance, which is at least partially due to the lack of error growth in dynamical fields and model biases. © 2010 American Meteorological Society.
Messner S.F.,Albany State University
Criminology | Year: 2012
This Presidential Address explores the possibilities for fruitful multilevel theorizing in criminology by proposing an integration of insights from situational action theory (SAT), a distinctively micro-level perspective, with insights from institutional anomie theory (IAT), a distinctively macro-level perspective. These perspectives are strategic candidates for integration because morality plays a central role in both. IAT can enrich SAT by identifying indirect causes of crime that operate at the institutional level and by highlighting the impact of the institutional context on the perception-choice process that underlies crime. Such multilevel theorizing can also promote the development of IAT by revealing the "micro-instantiations" of macro-level processes and by simulating further inquiry into the social preconditions for institutional configurations that are conducive to low levels of crime. Finally, drawing on Durkheim's classic work on occupational associations, I point to the potential role of professional associations such as the American Society of Criminology in promoting and sustaining a viable moral order in the advanced capitalist societies. © 2012 American Society of Criminology.
Savoie P.R.,Albany State University |
Welch J.T.,Albany State University
Chemical Reviews | Year: 2015
The utility of the pentafluorosulfanyl group in medicinal, agrichemical, and materials applications is expanding. The innovative preparation of pentafluorosulfanylarenes in an economic and efficient process without the need for molecular fluorine may be the most transformative advance of all. the cost of pentafluorosulfanyl substitution can be dramatically reduced, perhaps to a cost similar to that of trifluoromethyl substituents, thereby expanding the number of SF5-containing building blocks available to discovery chemists. Even with the breakthrough methods of Dolbier, the necessary pentafluorosulfanyl halide reagents remain difficult to prepare and expensive. Reactions of these precious reagents are limited to radical addition processes, a property that dramatically constrains options for late-stage introduction of the functional group.
Agency: NSF | Branch: Standard Grant | Program: | Phase: S-STEM:SCHLR SCI TECH ENG&MATH | Award Amount: 649.93K | Year: 2016
This NSF Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM) project will increase the number of students, who major in STEM disciplines at Albany State University and go on to successfully pursue STEM post-graduate education or research careers. During the project, 18 scholars will (a) develop and follow a four-year academic and professional plan that will include freshman learning community courses, workshops, service learning, and field trips or visitations under the guidance of a Student Success Coach, (b) participate in at least one undergraduate research experience, and (c) attend and present an undergraduate research project at an on-campus or regional conference. After graduation these talented scholars are expected to join the STEM workforce or go on to graduate school in STEM, enabling the US to compete and innovate in a global economy.
The theory of action for this project is that psychosocial factors such as STEM identity and self-efficacy are particularly critical to retaining STEM students. Thus, the project elements are designed to help students to develop these factors through a strong cohort anchored around a freshman learning community, targeted and intrusive advising, mentoring by faculty and peers, and participation in undergraduate research and internships. Evaluation will address the projects success in achieving its retention, course pass rate, and graduation objectives. Data analysis of student academic performance and participation in program activities will be used to study the effects of interventions like the learning community and intrusive advising on self-efficacy and science identity for students at a Historically Black University. The research results will be disseminated at the University System of GA Teaching and Learning Conference and the Understanding Interventions that Broaden Participation in STEM Careers conference. Manuscripts will be submitted to the Journal of Higher Education and the Journal of College Science Teaching.
Agency: NSF | Branch: Continuing grant | Program: | Phase: HIST BLACK COLLEGES AND UNIV | Award Amount: 1.28M | Year: 2014
Implementation Projects provide support to Historically Black Colleges and Universities (HBCUs) to design, implement, study, and assess comprehensive institutional efforts to increase the number of students receiving undergraduate degrees in STEM and enhance the quality of their preparation by strengthening STEM education and research. The project at Albany State University seeks to build on previous successful efforts to increase participation of African-American students in STEM disciplines. A component of the project is a Learning Community-as-Teaching Laboratory where faculty will focus on pedagogical approaches that best assist students to develop the skills needed for success in the STEM disciplines. The project will employ a cross-disciplinary approach, using faculty from both the natural sciences and education, who will employ evidence-based methods of teaching to enhance student learning.
The project has four specific goals: 1) to increase the number of entering freshmen in STEM majors; 2) to increase the STEM graduation rate; 3) to develop strong STEM skills, such as problem solving skills, critical thinking skills, research skills, and the application of the skills in the content areas in gatekeeper courses; and 4) to implement a professional development partnership in STEM teaching. The goals will be accomplished through faculty professional development, a support system for students, a learning community, and an integrated vertically aligned curriculum. The project seeks to create an intensive Sustained Support System for Students who are interested in STEM but who are at risk of not performing well and dropping out, providing them with the skills and motivation to persist in STEM majors. Through the evaluation plan, the project seeks to study the effects of these interconnected approaches as models for other HBCUs that are predominantly teaching institutions.
Agency: NSF | Branch: Standard Grant | Program: | Phase: HIST BLACK COLLEGES AND UNIV | Award Amount: 432.60K | Year: 2014
The Historically Black Colleges and Universities Undergraduate Program (HBCU-UP) through Targeted Infusion Projects supports the development, implementation, and study of evidence-based innovative models and approaches for improving the preparation and success of HBCU undergraduate students so that they may pursue STEM graduate programs and/or careers. Albany State University will implement a project entitled: Course-embedded Model Utilizing Nanoscience and Nanotechnology to Integrate Research based Projects into the Science Curriculum. The project will transform the undergraduate science curriculum at the institution by infusing nanotechnology based research in the laboratory. Project objectives include the infusion of research experiences in chemistry, biology and physics courses; enhancement of students content knowledge of the field of nanoscience and technology; and, enhancement of students research and critical thinking skills. The broader impacts of the project are in the training of undergraduate students for interdisciplinary research, as well as outreach programs to K-12 students and professional development workshops for high school teachers to develop or adapt activities in nanotechnology for implementation into the K-12 curriculum.
The integratation of research into the curriculum is accomplished by concentrating on three tracks of research in nanotechnology. The tracks are: the biomedical application of carbon nanomaterials, where synthesis, functionalization, characterization, wave-nanoparticle interactions and delivery applications of graphene and ferrite nanoparticles are investigated; the study of nanoparticles on living organisms where the focus is on the effect of nanoparticles on human cells, plants, and microorganisms and biological macromolecules; and an introduction of nanotechnology where students prepare gold nanoparticles under varying conditions and characterize and study their catalytic properties. This project connects the disciplines of chemistry, biology and physics using nanotechnology as the central theme for the integration of the research into the curriculum.