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Objectives: To examine the effects on bone tissues of immediate implant-supported mandibular overdentures with cusped or cuspless teeth. Methods: A randomized controlled trial was conducted at the Dental Clinic, Faculty of Dentistry, Al-Azhar University, Assiut Branch, Egypt, over a 12-month period from September 2013 to September 2014. Twenty patients were treated with immediate implant-supported overdentures: one group received overdentures with cusped teeth, and the other group received overdentures with cuspless teeth. Te rate of implant success was assessed clinically and radiographically at 3, 6, 9, and 12 months. Te data were collected by a questionnaire, an observation checklist, and radiography. Te data were then analyzed using computerized methods. Results: Overdentures with cusped teeth showed a significant improvement in the clinical criteria, including the absence of clinical implant mobility, pain, and bone resorption, while the clinical criteria for the absence of peri-implant radiolucency were insignificantly different between the 2 groups (p>0.05). Tere were no significant differences in the clinical evaluations for bone levels at the time of insertion or 3 months after insertions, while significant differences were found at 6, 9, and 12 months after insertion. Conclusion: Overdentures with cusped teeth supported by immediate implants were found superior regarding many clinical criteria than those cuspless counterparts. © 2016, Saudi Arabian Armed Forces Hospital. All rights reserved.

Alharbi R.A.,University of Surrey | Alharbi R.A.,Albaha University | Pettengell R.,St Georges, University of London | Pandha H.S.,University of Surrey | Morgan R.,University of Surrey
Leukemia | Year: 2013

The homeobox (HOX) genes are a highly conserved family of homeodomain-containing transcription factors that specify cell identity in early development and, subsequently, in a number of adult processes including hematopoiesis. The dysregulation of HOX genes is associated with a number of malignancies including acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), where they have been shown to support the immortalization of leukemic cells both as chimeric partners in fusion genes and when overexpressed in their wild-type form. This review covers our current understanding of the role of HOX genes in normal hematopoiesis, AML and ALL, with particular emphasis on the similarities and differences of HOX function in these contexts, their hematopoietic downstream gene targets and implications for therapy. © 2013 Macmillan Publishers Limited All rights reserved.

Alqumber M.A.,Albaha University
Saudi Medical Journal | Year: 2014

Objectives: To determine Clostridium difficile (C. difficile) prevalence on retail surfaces and shoppers plastic bags.Methods: From 20 June to 10 August 2011, in a crosssectional epidemiological study, 17 supermarkets from 2 cities, Albaha and Altaif, Saudi Arabia were sampled. A total of 800 samples, which comprised 200 samples per surveyed surface, were studied. These included baskets, trolleys, conveyer belts, and outgoing shoppers’ plastic bags. Clostridium difficile strains were isolated. The isolates were characterized using ribotyping and polymerase chain reaction for the detection of toxin A (tcdA), toxin B (tcdB), binary toxin (cdtB), and toxin C (tcdC) genes. Susceptibility to antibiotics was determined on a Muller-Hinton agar with 5% sheep blood agar using E-tests.Results: Overall, the C. difficile prevalence on sampled surfaces was 0.75%. The highest prevalence was found on retail baskets and trolleys, followed by plastic bags. A total of 5 different ribotypes were identified. Alterations in tcdC were detected in ribotype 027 and BT1. All the identified isolates were susceptible to vancomycin, but resistant to levofloxacin.Conclusion: In this study, C. difficile was present at a rate of 0.75% on supermarket surfaces. Spore disinfection of implicated surfaces may be necessary to control any community-acquired infections caused by this pathogen. © 2014, Saudi Medical Journal. All rights reserved.

Alqumber M.A.,Albaha University
Saudi Medical Journal | Year: 2014

Objectives: To investigate for the presence of mycobacteria at water dams of Albaha, Saudi Arabia. Methods: An epidemiological study was conducted between 20 - 30 June 2013 in the Albaha region, Kingdom of Saudi Arabia. Five hundred and twenty samples (sand, wet stones, clay, and decayed vegetation) were collected from 13 dams in the region. These locations were: 3 dams from Alaqiq city (Trad, Alaqiq, and Almshereq); 4 dams from Almandaq city (Almudlamat, Alkhrar, Alsader, and Medhas); one dam from Albaha city (Shehba'a); and 5 dams from Baljerashi city (Alzarawah, Alareshaen, Almatwah, Alheajh, and Almarbah). Samples from these locations (n=520) were inoculated on Lowenstein-Jensen media. Te isolated Mycobacterium (M.) obtained were identified by standard culture, enzymatic tests, biochemical characteristics, comparison of mycolic acid profiles, 16S rRNA gene sequencing, and restriction fragment patterns of the hsp65 gene polymerase chain reaction product. Results: Mycobacterium isolates were recovered from 79% of the samples obtained from all types of samples and locations. A total of 145 of the isolates were found to belong to the 11 Mycobacterium species: 5 M. intracellulare, 8 M. abscessus, 9 M. szulgai, 12 M. fortuitum, 12 M. avium, 14 M. kansasii, 15 M. simiae, 15 M. gordonae, 16 M. terrae complex, 18 M. chelonae, and 21 M. malmoense. Conclusion: Mycobacterium species is present at high percentages in Albaha dams. The findings support a nationwide study to understand the clinical importance of environmental Mycobacterium in Saudi Arabia.

Arafa K.A.,Albaha University
Life Science Journal | Year: 2014

Three different designs of clasp (RPI clasp, wrought wire clasp and RPL clasp) designed for distalextension removable partial dentures (RPDs) were assessed in Kennedy class I patients' mouths. The assessment, included the Gingival index, mobility and epithelial attachment loss of the abutments when loaded on a free-end RPD occlusal surface. The abutment mobility of the three types of retainers were all within the 'mobile ability area' except the wrought wire clasp. The greatest tooth mobility was observed with the wrought wire clasps, followed by RPL clasp. From the analysis the following was concluded that, the different clasps do influence the occlusal load distribution.

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