Albaath University

University of Technology of Compiègne, France

Albaath University

University of Technology of Compiègne, France
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Teow H.M.,University of Central Lancashire | Zhou Z.,University of Central Lancashire | Najlah M.,Albaath University | Yusof S.R.,King's College London | And 3 more authors.
International Journal of Pharmaceutics | Year: 2013

The aim of this study was to investigate the ability of a third-generation (G3) polyamidoamine (PAMAM) dendrimer-based carrier to enhance the permeability of paclitaxel (pac) and to overcome cellular barriers. G3 dendrimers were surface modified with lauryl chains (L) and conjugated with paclitaxel (pac) via a glutaric anhydride (glu) linker, followed by labeling with FITC. Biological evaluation of the dendrimer and conjugates was conducted using the human colon adenocarcinoma cell line (Caco-2) and primary cultured porcine brain endothelial cells (PBECs). LDH assay was used to evaluate the cytotoxicity of the dendrimer and conjugates. Cytotoxicity studies showed that the conjugation of lauryl chains and paclitaxel on G3 dendrimer significantly (p < 0.05) increased the cytotoxicity against both cell types. Permeability studies of dendrimer-drug conjugates demonstrated an increase in the apparent permeability coefficient (Papp) in both apical to basolateral A → B and basolateral to apical B → A directions across both cell monolayers compared to unmodified G3 and free drug. The B → A Papp of paclitaxel was significantly (p < 0.05) higher than the A → B Papp, indicating active function of P-gp efflux transporter system in both cell models. L6-G3-glu-pac conjugate had approximately 12-fold greater permeability across both cell monolayers than that of paclitaxel alone. © 2012 Elsevier B.V. All rights reserved.

Alahmad Y.,University Paris - Sud | Alahmad Y.,Albaath University | Tran N.T.,University Paris - Sud | Le Potier I.,University Paris - Sud | And 3 more authors.
Electrophoresis | Year: 2011

We present a new CZE method, which uses a polyethylene oxide-coated capillary to separate native HSA from more than five of its structural variants. These variants include oxidized, truncated, and cysteinylated forms of HSA which can all be found in biopharmaceutical products. Both CE and MS confirmed the high degree of heterogeneity of HSA preparations. Recovery studies demonstrated that adsorption of HSA on the capillary was significantly reduced under the conditions we developed, which led to a satisfactory repeatability (RSD for migration times and relative peak areas were less than 0.2 and 7.0%, respectively). Assignment of the main peaks was attempted using in vitro degraded/stressed HSA. We used our method to test batch-to-batch comparability and detected slight quantitative differences in the proportion of native HSA in batches produced from different fractionation methods. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Alnahhas B.,Damascus University | Hassan A.,Damascus University | Alhosini H.,Albaath University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2012

The purpose of this research is to find a rapid, sensitive and validated HPLC method for separation and determination of some thirdgeneration cephalosporins (ceftazidime, ceftriaxone, cefotaxime), the three cephalosporins are separated on reversed-phase C18 column using isocratic elution, the mobile phase containing: (30% Methanol and 70% potassium dihydrogen phosphate 40mM) pH is adjusted to 3.5 by the addition of orthophosphoric acid, the samples were detected at 254nm. The qualitative study of the method included the effect of temperature, flow rate, ratio of the components of the mobile phase, pH value and concentration of the buffer on the quality of separation, the linear range of the three compounds is between 32 and 48 ìg/ml, the relative standard deviation for precision is not more than (2%). The linearity, selectivity, accuracy and robustness of the developed method show acceptable values. The method was applied to samples of many pharmaceutical preparations of those compounds and to spiked serum samples. Recoveries from serum samples ranged between 91.225 and 95.759 %. Then it was applied to serum samples of patients using ceftazidime, the method is suitable for quality control of ceftazidime, ceftriaxone and cefotaxime in their mixtures and in pharmaceutical preparations. It can be used also to determine their concentration in serum.

Ghata A.J.,Albaath University | Sadek S.,Al-Baath University | Abod R.,Albaath University
Petroleum and Coal | Year: 2013

The aim of the research is to improve the yield of the biomass and to remove the organic matters of the whey by using a mixed culture of (Saccharomyces cerevisiae+ Kluyveromyces lactis) yeast at rate 1/1. The optimal conditions of growth of the mixed culture of the (Saccharomyces cervisiae+ Kluyveromyces lactis) have been identified on a Rider medium and they have been as follows: pH: 5.5, air flow: 0.5 liter air /liter whey /min, and temperature: 30 C° The aerobic biological treatment technique of the whey has been achieved by using the mixed culture of (Saccharomyces cervisiae+ Kluyveromyces lactis) yeast at rate 1% and at the optimal and specified conditions of growth, So that the value of the COD can be reduced from 65000 mg / L to 514 mg / L with COD removal efficiency of 99.21%, and the forming biomass 3.53%.

Albarhoum M.,Syrian Atomic Energy Commission | Soufan A.H.,AlbaAth University | Mustafa H.,AlbaAth University
Annals of Nuclear Energy | Year: 2011

The shielding properties of the concrete and blocks used for the construction of dwelling houses in the Central Region of Syria (CRS) were measured and studied. The concrete used for the ceiling construction was found to have optimum shielding properties with 0.182 cm-1 (or equivalently 0.0859 cm2 g-1) for the linear (mass) attenuation coefficient [L(M)AC]. In addition gamma radiation is attenuated by 73.221% on average, while the blocks used for the walls have smaller LACs (0.082 cm -1 for the bare blocks, and 0.118 cm-1 for the coated ones). Although the LACs for the blocks are smaller than those for the concrete their shielding properties are good to protect from the gamma radiations coming from radioactive or nuclear accidents (78.630% attenuation), even Chernobyl - like disasters, because of their big width (10-12 cm). The LACs were measured by an ionization chamber and simple theoretical calculations have been made to predict the concrete LACs. The calculations showed an average LAC for the six samples equal to 0.1664 cm-1 with 8.47% error with respect to the experimental values. The average LAC for the concrete used for ceiling construction in the CRS was found to be comparable or even better than the average of some international values for the reactor shielding concretes, which are about 0.163 cm-1. © 2011 Elsevier Ltd. All rights reserved.

Nasr M.,Ain Shams University | Nasr M.,University of Central Lancashire | Najlah M.,Albaath University | D'Emanuele A.,University of Central Lancashire | Elhissi A.,University of Central Lancashire
International Journal of Pharmaceutics | Year: 2014

Polyamidoamine (PAMAM) dendrimers were evaluated as nanocarriers for pulmonary delivery of the model poorly soluble anti-asthma drug beclometasone dipropionate (BDP) using G3, G4 and G4(12) dendrimers. BDP-loaded dendrimers were characterized for drug solubility, in vitro drug release and aerosolization properties using three nebulizers: Pari LC Sprint (air-jet), Aeroneb Pro (actively vibrating-mesh) and Omron MicroAir (passively vibrating-mesh) nebulizers. Solubilization of BDP using dendrimers was increased by increasing the dendrimer generation and by using higher pH media. In vitro release studies showed that BDP when complexed with dendrimers exhibited a sustained release, and for all dendrimer formulations less than 35% of the drug was released after 8 h. Nebulization studies revealed that aerosol performance was dependent on nebulizer rather than dendrimer generation. Nebulization output values for the Pari (air-jet) and Aeroneb Pro (active mesh) nebulizers were in the range of 90-92% and 85-89% respectively compared to 57-63% for the Omron (passive mesh) nebulizer. The size of the droplets generated from the jet nebulizer was slightly smaller and aerosol polydispersity was lower compared to both mesh devices. The "fine particle fraction (FPF)" of the aerosols was in the following order: Pari (air-jet) > Aeroneb Pro (active mesh) > Omron (passive mesh). This study demonstrates that BDP-dendrimers have potential for pulmonary inhalation using air-jet and vibrating-mesh nebulizers. Moreover, the aerosol characteristics are influenced by nebulizer design rather than dendrimer generation. © 2013 Elsevier B.V. All rights reserved.

Al-Ne'Aimi M.M.,University of Mosul | Al-Khuder M.M.,Albaath University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

In this study, diacetylmonoximebenzoylhydrazone (L1H 2) and 1,4-diacetylbenzene bis(benzoyl hydrazone) (L 2H2) were synthesized by the condensation of benzohydrazide with diacetyl monoxime and 1,4-diacetylbenzene, respectively. Complexes of these ligands with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) inos were prepared with a metal:ligand ratio of 1:2 for L1H2 ligand, and 1:1 for L2H2 ligand. The ligands and their complexes were elucidated on the basis of elemental analyses CHN, AAS, FT-IR, 1H- and 13C NMR spectra, UV-vis spectra and magnetic susceptibility measurements. Results show the L1H2 ligand act as monoanionic O,N,N-tridentate and coordination takes place in the enol form through the oxime nitrogen, the imine nitrogen and the enolate oxygen atoms with a N4O2 donor environment, while the L 2H2 ligand act as a dianionic O,N,N,O-tetradentate and coordination takes place in the enol form through the enolate oxygen and the azomethine nitrogen atoms with a N2O2 donor environment. These results are consistent with the formation of mononuclear metal (II) complexes [M(L1H)2], and binuclear polymeric metal (II) complexes [{M2(L2)}n]. The extraction ability of both ligands were examined in chloroform by the liquid-liquid extraction of selected transition metal [Co2+, Ni2+, Cu2+, Zn2+ and Pb2+] cations. The effects of pH and contact time on the percentage extraction of metal (II) ions were studied under the optimum extraction conditions. The (L1H2) ligand shows strong binding ability toward copper(II) and lead(II) ions, while the (L 2H2) ligand shows strong binding ability toward nickel(II) and zinc(II) ions. © 2012 Elsevier B.V. All rights reserved.

PubMed | Boston University, Tishreen University and Albaath University
Type: Journal Article | Journal: International orthodontics | Year: 2016

Maxillary transverse deficiency (MTD) is one of the most pervasive and common skeletal problems in the craniofacial complex. This study aimed to evaluate the effect of associating the application of Erbium-YAG laser with rapid maxillary expansion (RME) for treating MTD in young adult patients with permanent dentition in regard to skeletal and dental effects.Twenty-four subjects, aged from 15.5 to 19 years and needing RME as a therapeutic procedure, were randomly assigned to either the laser group (n=12) or the control group (n=12). The RME was realized by a two bands hyrax expander cemented on upper first molars. Patients in the laser group were undergone mucosal-bony perforations along the midpalatal suture every month, for three consecutive months, using Erbium-YAG laser. Postero-anterior cephalograms were taken for all patients. Skeletal and dental changes before and after RPE as well as at the end of the retention phase were collected and compared for both groups. Total time needed for expansion and retention were recorded and compared.The findings showed more significant changes in most maxillofacial components in the laser group after the expansion phase. However, there was no significant differences with respect to retention or total treatment duration.Laser assisted rapid maxillary expansion (LARME) can be a good approach to use for improving skeletal effects in young adult patients suffering from MTD.

Wahoud A.,Albaath University | Alouche A.,Albaath University | Abdulbake M.,Albaath University
Periodica Polytechnica: Chemical Engineering | Year: 2011

Vanadium, iron and aluminum were recovered from the spent sulfuric acid catalyst with efficiency of 98%, 95% and 85%, respectively by using low temperature sulphuric acid baking followed by leaching. The optimum baking conditions were four grams of concentrated sulfuric acid per ten grams of spent catalyst at 300 C for two hours. Sulphuric acid baking followed by leaching was found to be the best and it is more effective in Iron and Aluminum dissolution. Sulfuric acid baking is expected to consume small amount of chemicals and generate much less waste effluents during the separation process of metals with alkali solutions. It is economically favorable, as it avoids us much more environmental contamination. © Periodica Polytechnica 2011.

Almasri R.,Albaath University | Muneer T.,Napier University | Cullinane K.,Napier University
Energy Policy | Year: 2011

Statistics show that the number of cars per capita in Syria is still low, but that the figure has more than doubled since 2004. Syria also suffers from inadequate public transport provision, poor infrastructure and the absence of suitable traffic management systems, with the average speed of road transport in Damascus at about 4-5. km/h. Only until very recently, a comprehensive network for the continuous monitoring of air pollutants has been lacking. This paper reviews, collates and synthesises the results of numerous studies of Syrian road transport, with an emphasis on air pollution from Syria's transport and energy production sectors. It is revealed that what studies that have been done show that the air quality in Syrian urban areas falls below established national air quality standards, especially during winter when the demand for heating is high. The paper proposes a number of suggestions to improve air quality in Syria by using greener and more public transport, promoting and incentivising rational and efficient energy consumption in all sectors, taking advantage of available renewable energy resources, establishing an active network for routine measurement of pollution, setting local emissions standards that are in line with international standards and which are supported by the imposition of penalties, fines or taxation on polluting agents. © 2011 Elsevier Ltd.

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