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Do Amaral Soares I.,Federal University of Sao Paulo | De Lemos Menezes P.,Alagoas State University of Health Sciences | Pereira L.D.,Unifesp
Pro-Fono | Year: 2010

Background: standardization of Brainstem Auditory Evoked Potential (BAEP) using a new device. Aim: to standardize BAEP responses using a new device developed (NDD) in Brazil. Method: analysis of absolute latencies, interpeaks and wave amplitudes of BAEP, using a new device developed to study normal-hearing groups (91 adults) and individuals (15 adults) with bilateral neurosensory hearing loss. Responses obtained in the EP15 hearing device/Interacoustics and the NDD were compared. For this, the following paramenters were used: non-filtered click of 100 microsecond (μs), totaling 2000 stimuli in rarefied polarity, stimulation frequency of 13.1 clicks/s, intensity of 80 decibels normalized hearing level (dB nHL), with a window of 10 milliseconds and bandpass filter between 100 and 3000 Hertz (Hz). Significance level was set at 0.05. Results: absolute latency and interpeak means for 76 normal-hearing individuals with the NDD were: wave I=1.50, III=3.57, V=5.53, I-III=2.06, III-V=1.96 and I-V=4.02. When analyzing results according to gender, there was a statistically significant difference for the absolute latencies of waves III and V and in interpeaks I-III and I-V. Mean amplitude value of wave I=0.384 microvolt (μV) and of wave V=0.825 μ V. There was no statistically significant difference between the absolute latencies and interpeaks of the two devices in the same individual. Conclusion: the components of BAEP with the NDD in normal-hearing subjects were similar regarding the tested ears, with statistically lower latencies in women. The BAEP latencies in the same individual with NDD were similar to those obtained with the EP15/Interacoustics. Normal values of BAEP were obtained in normal-hearing adults. Source


Quini C.C.,Sao Paulo State University | Americo M.F.,Federal University of Mato Grosso | Cora L.A.,Alagoas State University of Health Sciences | Calabresi M.F.F.,Sao Paulo State University | And 3 more authors.
Journal of Biological Engineering | Year: 2012

AC Biosusceptometry (ACB) was previously employed towards recording gastrointestinal motility. Our data show a reliable and successful evaluation of gastrointestinal transit of liquid and solid meals in rats, considering the methods scarcity and number of experiments needed to endorsement of drugs and medicinal plants. ACB permits real time and simultaneous experiments using the same animal, preserving the physiological conditions employing both meals with simplicity and accuracy. © 2012 Quini et al.; licensee BioMed Central Ltd. Source


Teixeira M.C.,Alagoas State University of Health Sciences
Transplantation proceedings | Year: 2012

Gastrointestinal (GI) complications are common after renal transplantation, mainly owing to immunosuppressive therapy. Assessment of GI transit time can facilitate rational management of these disorders. We evaluate the GI transit parameters in renal transplant recipients taking tacrolimus, azathioprine, and prednisone with the use of the alternate current biosusceptometry (ACB) technique and compared them with healthy volunteers. Ten renal transplant recipients and 10 healthy volunteers were enrolled in this study. After an overnight fast, patients and volunteers ingested a standard meal containing magnetic markers. The biomagnetic monitoring was performed at 10-minute intervals for at least 8 hours to obtain gastric emptying as well as the colonic arrival time-intensity curves. Mean gastric emptying time (MGET), mean colon arrival time (MCAT), and mean small intestinal transit time (MSITT) were quantified and compared between control and patient groups with results expressed as mean ± SD. The MGET measured by the ACB technique was 48 ± 31 minutes and 197 ± 50 minutes for patients and healthy subjects, respectively. MSITT and MCAT values calculated for patients versus volunteers were 171 ± 71 minutes versus 197 ± 71 minutes and 219 ± 83 minutes versus 373 ± 52 minutes, respectively. Renal transplant recipients showed significantly faster; gastric emptying and colon arrival times (P < .001) compared with normal volunteers; however, small intestinal transit time was not significantly different (P = .44). In stable renal transplant recipients, the GI transit parameters were significantly faster than in normal healthy volunteers. ACB sensors are versatile technologies that can be used for clinical research, because they offer an excellent opportunity to evaluate GI transit in a noninvasive manner without the use of ionizing radiation. Copyright © 2012 Elsevier Inc. All rights reserved. Source


Kassar S.B.,Alagoas State University of Health Sciences | Melo A.M.C.,Federal University of Alagoas | Coutinho S.B.,Federal University of Pernambuco | Lima M.C.,Federal University of Pernambuco | Lira P.I.C.,Federal University of Pernambuco
Jornal de Pediatria | Year: 2013

Objective: To identify risk factors for neonatal mortality, focusing on factors related to assistance care during the prenatal period, childbirth, and maternal reproductive history. Methods: This was a case-control study conducted in Maceió, Northeastern Brazil. The sample consisted of 136 cases and 272 controls selected from official Brazilian databases. The cases consisted of all infants who died before 28 days of life, selected from the Mortality Information System, and the controls were survivors during this period, selected from the Information System on Live Births, by random drawing among children born on the same date of the case. Household interviews were conducted with mothers. Results: The logistic regression analysis identified the following as determining factors for death in the neonatal period: mothers with a history of previous children who died in the first year of life (OR = 3.08), hospitalization during pregnancy (OR = 2.48), inadequate prenatal care (OR = 2.49), lack of ultrasound examination during prenatal care (OR = 3.89), transfer of the newborn to another unit after birth (OR = 5.06), admittance of the newborn at the ICU (OR = 5.00), and low birth weight (OR = 2.57). Among the socioeconomic conditions, there was a greater chance for neonatal mortality in homes with fewer residents (OR = 1.73) and with no children younger than five years (OR = 10.10). Conclusion: Several factors that were associated with neonatal mortality in this study may be due to inadequate care during the prenatal period and childbirth, and inadequate newborn care, all of which can be modified. © 2013 Sociedade Brasileira de Pediatria. Source


Marques R.G.,Sao Paulo State University | Americo M.F.,Federal University of Mato Grosso | Spadella C.T.,Sao Paulo State University | Cora L.A.,Alagoas State University of Health Sciences | And 2 more authors.
Physiological Measurement | Year: 2014

The relationship between time-courses of mechanical and electrical events in longstanding diabetes was investigated in rats. Magnetic markers and electrodes were surgically implanted in the gastric serosa of male rats. Simultaneous recordings were obtained by AC biosusceptometry, electromyography and electrogastrography one, three and six months after injections of saline (control) or alloxan (diabetic). Frequency and amplitude of contraction, abnormal rhythmic index and half-bandwidth were obtained (ANOVA P < 0.05). Antral hypomotility and gastric motility instability were observed in the signal waveform of diabetic rats at the three time points of study. The mean frequency (4.4 ± 0.4 cpm) was strictly similar, but the mechanical and electrical correlation was lowest for diabetics groups. Decreases in mechanical amplitude were observed for all diabetic groups compared with control; also the ranges of frequency were much wider in diabetes. The half-bandwidth increased since the first month in mechanical recordings and only after the third month in electrical. In diabetic animals, about 40% of gastric activity was abnormal (against 12% in control) and may reach 60% in the sixth month of mechanical recordings. The multi-instrumental approach showed a more substantial deterioration in mechanical activity and created an integrative view of gastric motility for longstanding diabetic model. © 2014 Institute of Physics and Engineering in Medicine. Source

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