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El-Sayed K.M.,Al Kharj University | Khalil H.,King Saud University
International Journal of Oral and Maxillofacial Surgery | Year: 2010

Alveolar bone grafting is a standard method for treating alveolar cleft. To ensure the best outcome, improving the arch form as well as soft tissue quality in the area around the cleft is recommended. In this study, 11 patients who presented with alveolar cleft and collapsed maxillary arch were treated in the following sequence: transpalatal distraction osteogenesis followed by soft tissue surgery in some cases and by cancellous bone graft. In all cases, transpalatal distraction osteogenesis successfully corrected the transverse maxillary deficiency. One case showed a complete loss of the bone graft. Other minor complications were reported but they did not affect the final outcome. © 2010 International Association of Oral and Maxillofacial Surgeons. Source

El-Azab A.S.,King Saud University | Al-Omar M.A.,King Saud University | Abdel-Aziz A.A.-M.,King Saud University | Abdel-Aziz N.I.,Mansoura University | And 4 more authors.
European Journal of Medicinal Chemistry | Year: 2010

Novel derivatives of quinazoline (1-27) have been synthesized and tested for their antitumor activity against three tumor cell lines among these cell lines the human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. All tested compounds showed potent and selective activity against breast cancer (MCF-7) with IC50 range of 3.35-6.81 μg/ml. With regarding broad-spectrum activity compounds 5, 9, 15, 18 and 20 exploited potent antitumor against human liver cell line (HEPG2), human breast cell line (MCF-7) and human cervix cell line (HELA) with IC50 range of 3.35-5.59 μg/ml. Virtual screening was carried out through docking the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) to predict if these compounds have analogous binding mode to the EGFR inhibitors. © 2010 Elsevier Masson SAS. All rights reserved. Source

Yassin A.E.B.,King Saud University | Khalid Anwer M.D.,Al Kharj University | Mowafy H.A.,King Saud University | El-Bagory I.M.,King Saud University | And 2 more authors.
International Journal of Medical Sciences | Year: 2010

Solid lipid nanoparticle (SLNs) formulae were utilized for the release of 5-fluorouracil (5-FU) inside the colonic medium for local treatment of colon cancer. SL Ns were prepared by double emulsion-solvent evaporation technique (w/o/w) using triglyceride esters, Dynasan™ 114 or Dynasan™ 118 along with soyalecithin as the lipid parts. Different formulation parameters; including type of Dynasan, soyalicithin: Dynasan ratio, drug: total lipid ratio, and polyvinyl alcohol (PVA) concentration were studied with respect to particle size and drug entrapment efficiency. Results showed that formula 8 (F8) with composition of 20% 5 -FU, 27% Dynasan™ 114, and 53% soyalithicin and F14 (20% 5-FU, 27% Dynasan™ 118, and 53% soyalithicin), which were stabilized by 0. 5% PVA, as well as F10 with similar composition as F8 but stabilized by 2% PVA were considered the optimum formulae as they combined small particle sizes and relatively high encapsulation efficiencies. F8 had a particle size of 402.5 nm ± 34.5 with a polydispersity value of 0.005 and an enca psulati on efficiency of 51%, F10 had a 617. 3 nm ± 54. 3 particle size with 0.005 polydispersity value and 49.1% encapsulation efficiency, whereas formula F14 showed a particle size of 343 nm ± 29 with 0.005 polydispersity, and an encapsulation efficiency of 59. 09%. DS C and FTIR results suggest ed the existence of t he lipids in the solid crystalline state. Incomplete biphasic prolonged release profile of the drug from The three formulae was observed in phosphate buffer p H 6. 8 as well as simulated colonic medium containing rat caecal contents. A burst release with magnitudes of 26%, 32% and 28.8% cumulative drug released were noticed in the first hour samples incubated in phosphate buffer p H 6. 8 for both F8, F10 and F14, respectively, followed by a slow release profile reaching 50%, 46.3% and 52% after 48 hours. © Ivyspring International Publisher. Source

Alafeefy A.M.,Al Kharj University
Journal of Saudi Chemical Society | Year: 2011

A series of some new 2,3-disubstituted-6-iodo-3H-quinazolin-4-one derivatives was prepared and screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human cervix carcinoma cell line (HeLa), human liver cancer cell line (HepG2) and human colon cancer cell line HCT-8. Five compounds exhibited broad spectrum antitumor activity, better than the standard drug Doxorubicin (CAS-23214-92-8) against the four tested cell lines. In the present study, MCF-7 cell line was the most sensitive one, 12 compounds were good cytotoxic towards it. The best cytotoxic results were obtained with compounds bearing allyl and/or benzyl moiety at positions 2 and/or 3 of the quinazoline nucleus. © 2011 King Saud University. Source

Zedan Y.,Boulevard Of Luniversite | Alkahtani S.,Al Kharj University
Journal of Materials Processing Technology | Year: 2013

This study was conducted with the intention of investigating a new experimental alloy, namely the 396 alloy which belongs to the Al-Si near-eutectic cast alloy group and contains about 10.8%Si. In the light of the above, the main purpose of the work is to report on the changes observed in the mechanical and machinability criteria resulting from the effects of the presence of two levels of Cu, namely 2.25% and 3.5%; and of the effects of two levels of Mg, namely 0.3% and 0.6%. In addition to the preceding, the effects of Mg-free alloys and Sr-modification on these same alloys were also investigated. The results demonstrate that the increase in the levels of Cu and/or Mg in the 396-T6 alloy has a detrimental effect on drill life. Such an effect may be attributed to the formation of large amounts of the coarse blocklike Al 2Cu phase, together with the formation of thick plates of the Al-Si-Cu-Mg phase. The Mg-free experimental alloy displays the lowest cutting force and moment in addition to producing the highest number of holes in the alloys studied. This observation may be explained by the cooperative precipitation of the Al 2Cu, Mg 2Si, Al 2CuMg, and Al 5Si 6Cu 2Mg 8 hardening phases in Mg-containing alloys which confer greater strength on the alloy than would be the case with the precipitation of only the Al 2Cu phase in the Mg-free alloy. A comparison of the non-modified alloy and the Sr-modified alloy (containing the same level of Mg and Cu additions) in terms of the number of holes drilled, reveals that the morphology of Si particles has a noticeable effect in governing the tool life of near-eutectic Al-Si alloys. The chip breakability of the alloys containing the Al 2Cu phase is superior to that of the alloys containing Mg 2Si. Thus, combined additions of Cu and Mg are expected to further refine the size of the chips produced. © 2012 Elsevier B.V. Source

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