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Riyadh, Saudi Arabia

Tarakji B.,Al Farabi Colleges
The Gulf journal of oncology | Year: 2012

Hormone therapy is highly recommended on patients with breast cancer who show positive nuclear staining of the cancer cells. It is not known however whether salivary gland tumours can respond to hormone therapy. Twenty eight studies undertaken between 1980 to 2009 involving different types of salivary gland cancers were evaluated and taken into consideration the type of used antibody and the criteria to assess the intensity staining. This review has shown that estrogen progesterone and androgen receptors were detected in few cases of salivary gland tumours. Different types of used antibodies were identified, and the criteria of assessment of the staining intensity were different as well. The outcome of this review indicated that the growth of those tumours was not dependent on hormone function. It is recommended that sensitive and specific biochemical methods can be used to determine if estrogen and progesterone receptors can be detected in salivary gland cancers. It is necessary to use one criterion such as positive or negative nuclear staining to determine the existence of estrogen and progesterone receptors and to avoid any bias. The discrepancy in the results reflects a clear need for consensus on a protocol for scoring of immunohistochemical staining.

Al-Maswary A.A.,Sanaa University | Alhadainy H.A.-H.,Tanta University | Al-Maweri S.A.,Al Farabi Colleges | Al-Maweri S.A.,Sanaa University
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: The coronal leakage of bacteria and other irritants to the root canal system is one of the main factors that may result in clinical failure and affect the long term success of endodontic treatment. The Resilon/Epiphany obturation system has been developed as an alternative to gutta-percha and traditional sealers. Aim: This study aimed to evaluate and compare the coronal leakage between Resilon obturation material and gutta-percha using the same sealer. Materials and Methods: In this invitro study, 72 freshly extracted single-rooted human teeth were used, and were sectioned at CEJ with 13mm length. The roots were randomly divided into four groups. In Group I, 30 roots were obturated using Resilon and Epiphany SE sealer, Group II, 30 roots were obturated using gutta-percha and Epiphany SE. Group III and Group IV, 12 roots were used as control groups (positive and negative). The coronal leakage was measured using the dye penetration technique. Data were statistically analysed by a One-Way ANOVA test. Results: There was a significant difference between the two experimental groups where Resilon revealed less microleakage than gutta-percha group (p <0.05). Conclusion: Resilon is a suitable replacement for gutta-percha on the basis of its increased resistance to microleakage, but it failed to provide complete hermetic coronal sealing. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.

Hamdan-Mansour A.M.,University of Jordan | Nawafa'h D.N.A.,Royal Medical Services | Hanouneh S.I.,Al Farabi Colleges | Al Omari H.D.,Hashemite University
International Journal of Diabetes in Developing Countries | Year: 2016

The comorbidity between chronic physical conditions and psychosocial health became common interest for health professional and researchers. The purpose of this study was to investigate the relationship among health locus of control, self-efficacy, and life satisfaction in patients with type-II diabetes mellitus. Data were collected using cross-sectional, correlational design from 793 patients with type-II diabetes in regard to health locus of control, self-efficacy, biomarkers, and satisfaction with life scale. Mean of HbA1c was 7.5 (SD = 2.6). Patients had moderate to high perception of powerful others health locus of control, self-efficacy, and life satisfaction. Results also showed that self-efficacy (Beta =.29, p <.001) and powerful others health locus of control (HLOC) (Beta =.10, p =.012) were significant predictors of patients’ life satisfaction, while type of treatment (Beta = −.084, p =.054) was marginally significant predictor. HbA1c and other demographic factors were not associated with life satisfaction (p >.05). Health care professionals need to enhance patient’s self-efficacy and internal power of their patients for better health outcomes. Nurses and other health professionals need to emphasize the psychosocial health aspects of patients with chronic illnesses and, in particular, those diagnosed with type-II diabetes mellitus. © 2015, Research Society for Study of Diabetes in India.

Najeeb S.,University of Sheffield | Najeeb S.,Al Farabi Colleges | Khurshid Z.,University of Birmingham | Zafar M.S.,Taibah University | Ajlal S.,King Saud University
Medical Principles and Practice | Year: 2016

Light amplification by stimulated emission of radiation (laser) has been used widely in a range of biomedical and dental applications in recent years. In the field of restorative dentistry, various kinds of lasers have been developed for diagnostic (e.g. caries detection) and operative applications (e.g. tooth ablation, cavity preparation, restorations, bleaching). The main benefits for laser applications are patient comfort, pain relief and better results for specific applications. Major concerns for using dental lasers frequently are high cost, need for specialized training and sensitivity of the technique, thereby compromising its usefulness particularly in developing countries. The main aim of this paper is to evaluate and summarize the applications of lasers in restorative dentistry, including a comparison of the applications of lasers for major restorative dental procedures and conventional clinical approaches. A remarkable increase in the use of lasers for dental application is expected in the near future. © 2015 S. Karger AG, Basel.

Khurshid Z.,King Faisal University | Zohaib S.,King Faisal University | Najeeb S.,Al Farabi Colleges | Zafar M.S.,Taibah University | And 2 more authors.
International Journal of Molecular Sciences | Year: 2016

There has been a rapid growth in the interest and adaptation of saliva as a diagnostic specimen over the last decade, and in the last few years in particular, there have been major developments involving the application of saliva as a clinically relevant specimen. Saliva provides a “window” into the oral and systemic health of an individual, and like other bodily fluids, saliva can be analyzed and studied to diagnose diseases. With the advent of new, more sensitive technologies to detect smaller concentrations of analytes in saliva relative to blood levels, there have been a number of critical developments in the field that we will describe. In particular, recent advances in standardized saliva collection devices that were not available three to four years ago, have made it easy for safe, simple, and non-invasive collection of samples to be carried out from patients. With the availability of these new technologies, we believe that in the next decade salivary proteomics will make it possible to predict and diagnose oral as well as systemic diseases, cancer, and infectious diseases, among others. The aim of this article is to review recent developments and advances in the area of saliva specimen collection devices and applications that will advance the field of proteomics. © 2016 by the authors; licensee MDPI, Basel, Switzerland.

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