Vinitha B.,Vydehi Institute of Dental science and Research Center |
Fathima G.,Al Badar Rural Dental College and Hospital
Journal of Pharmacy and Bioallied Sciences | Year: 2013
Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.
Keshav R.,Vydehi institute of dental science and research |
Narayanappa U.,Al Badar Rural Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2015
Background and objectives: Expression of Proliferating Cell Nuclear Antigen (PCNA) well-correlates with the cell division. The suprabasal expression of PCNA is considered to be a marker of dysplastic oral mucosa indicating a special proliferative cellular state in those lesions. Oral submucous fibrosis (OSMF) is considered to be a premalignant condition with potential to get transformed into oral squamous cell carcinoma (OSCC). The present study was done to assess the PCNA expression in different grades and in different layers of epithelium of OSMF and to compare the expression of PCNA in OSMF with OSCC. Materials and Methods: A group of 40 histopathologically diagnosed, formalin fixed, paraffin embedded tissue samples were included in study. The study group was further divided into 2 groups; 30 OSMF and 10 OSCC. Theses samples were collected from Department of Oral and Maxillofacial Pathology, Government Dental College and Research Institute, Bangalore. The samples were subjected to immunohistochemical method using indirect immunoenzyme LSAB method. Results: All 40 cases showed positivity for PCNA. The percentage of positive cells was more in basal and suprabasal layer both in OSMF and OSCC, whereas the greater percentage of positive cells was seen in the superficial layer of OSCC. All OSMF cases showed positive expression in basal and suprabasal layer and only 77% of cases showed positive PCNA expression in the superficial layer with variable immunoreactivity and 23% did not show any positive staining in the superficial layer. The percentage of positive cells and the intensity of staining increased as the disease severity increased in OSMF. Conclusion: Increased proportion of cells expressed PCNA staining which are in proliferative layers of OSMF. This biomarker provides an insight into the biological behaviour of the condition that substantiates its potentially malignant nature and may also provide an intermediate end point in chemotherapeutic trials. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.
Beedimani R.S.,Kamineni Academy of Medical science and Research Center |
Kalmath B.,Al Badar Rural Dental College and Hospital
International Journal of Pharma and Bio Sciences | Year: 2014
Phosphodiesterase 5 (PDE5) is a key enzyme involved in the regulation of cGMPspecific signaling pathways in normal physiological processes such as smooth muscle contraction and relaxation. Initially, PDE5 inhibitors were developed as potential antianginal agents, but early clinical results were disappointing and the focus of these drugs moved to the treatment of Erectile Dysfunction (ED) based on the findings that nitric oxide and cyclic guanosine monophosphate were important mediators of penile erection. The overall goal of this review is to provide a comprehensive understanding of the current and potential therapeutic roles of the PDE5 enzyme inhibitors. Novel PDE5 inhibitors are highly selective for the PDE5 isoenzyme, and this may translate into potential novel indications and fewer adverse systemic effects. Larger scale, well designed clinical trials are needed to ascertain the safety, efficacy and costeffectiveness of PDE5 inhibitors in the future treatment of urological, cardiovascular, gastrointestinal, and central nervous system disorders.
PubMed | Al Badar Rural Dental College and Hospital
Type: Journal Article | Journal: Journal of cancer research and therapeutics | Year: 2016
Turmeric has been described in ayurveda, and is referred by different names in different cultures, the active principle called curcumin or diferuloylmethane, has been shown to exhibit numerous activities. Extensive research over the last half century has revealed several important functions of curcumin. It binds to a variety of proteins and inhibits the activity of various kinases. By modulating the activation of various transcription factors, curcumin regulates the expression of inflammatory enzymes, cytokines, adhesion molecules, and cell survival proteins. Various preclinical, clinical, and animal studies suggest that curcumin has potential as an antiproliferative, anti-invasive, and antiangiogenic, as a mediator of chemoresistance, chemopreventive, and as a therapeutic agent. Thus, curcumin a spice once relegated to the kitchen shelf has moved into the clinic and may prove to be Curecumin. Methodology and Objectives: The focus of this publication is to provide research on curcumin with scientific publications on curcumin indexed in PubMed, Google J-Gate including systematic reviews, randomized controlled trials (RCTs), observational studies, or case series reports for various potentially malignant disorders (PMDs) with special attention to studies on oral submucous fibrosis. This research will be valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, to initiate a pathway for a low-cost research plan for future clinical trials in this field with an emphasis on conducting studies in regions of the world where PMDs are prevalent.There is a lacunae for scientific review of curcumin for PMDs specially on OSMF. Appropriate therapeutic interventions are needed for the initial, intermediate, and advanced stages of the disease. High-quality RCTs should be initiated.
PubMed | Al Badar Dental College and Hospital and Al Badar Rural Dental College and Hospital
Type: | Journal: BMJ case reports | Year: 2016
Cemento-ossifying fibroma is a benign growth, considered to originate from the periodontal ligament. It is often encapsulated and predominantly located in the mandible, and presents as a slow-growing lesion, but may cause deformity if left untreated. The definitive diagnosis of these lesions requires integration of its clinical, radiological and histological features. We present a case of cemento-ossifying fibroma in relation to the lower left one-third of the face, and its management.
PubMed | Al Badar Rural Dental College and Hospital
Type: Journal Article | Journal: Indian journal of dental research : official publication of Indian Society for Dental Research | Year: 2016
Worldwide, oral carcinoma is one of the most prevalent cancers and is one of the most common causes of death. Toxicity by oxygen radicals has been suggested as an important cause of cancer. Several researchers have reported an association of plasma/serum uric acid with different cancers.The aim was to determine the serum uric acid level in patients with newly diagnosed oral squamous cell carcinoma (OSCC) and then to compare and correlate it with those of normal subjects and also to determine the role of uric acid in the etiology of OSCC.The study group included 41 OSCC patients and 40 age- and sex- matched healthy subjects as a control group. Estimation of serum urate concentration was determined enzymatically with a commercially available reagent. The data were statistically evaluated with Students t-test and Chi-square test using SPSS 11.5 software.The mean serum uric acid levels were very low with the study group as compared to control group and were very highly significant (t = 4.14, P < 0.001). It was also found that risk of OSCC was more in a study group with low serum uric acid levels with tobacco intake.This study showed that serum uric acid was lower in oral cancer patients compared with healthy volunteers and low serum uric acid was associated with increased risk of oral cancer development.
PubMed | Drs Sudha & Nageswara Rao Siddhartha Institute Of Dental Science, College of St. Joseph and Al Badar Rural Dental College and Hospital
Type: Journal Article | Journal: International journal of clinical pediatric dentistry | Year: 2016
To determine the prevalence of early childhood caries (ECC) and its risk factors in children of West Godavari district, Andhra Pradesh.A sample of 1,897 children between 24 and 71 months of age based on stratified cluster random sampling were clinically examined for dental caries using mouth mirror under day light. The parents/caregivers of each child were interviewed with a structured questionnaire. Data was analyzed using independent sample Students t-test and chi-square test.Out of the total 1,897 children, 796 were affected with ECC showing an overall prevalence of 41.9%, with boys showing a higher prevalence rate of 44.8% compared to girls (39.9%). Statistically significant correlations were found between ECC and consumption of sugary snacks (p < 0.0001) and mouth rinsing habit (p < 0.001).A higher prevalence of ECC was observed and most of the teeth were not restored.Koya S, Ravichandra KS, Arunkumar VA, Sahana S, Pushpalatha HM. Prevalence of Early Childhood Caries in Children of West Godavari District, Andhra Pradesh, South India: An Epidemiological Study. Int J Clin Pediatr Dent 2016;9(3):251-255.
PubMed | HKES SN Institute of Dental science and Research, NITTE University and Al Badar Rural Dental College and Hospital
Type: Journal Article | Journal: Journal of conservative dentistry : JCD | Year: 2016
To ascertain the role of One hundred and twenty human single-rooted extracted teeth divided into five groups. Group I (control): intact teeth, Group II: no apical treatment done, Group III divided into two subgroups. In Groups IIIa and IIIb, root apex treated with lactic acid of acidic and neutral pH, respectively. Group IV: apical root cementum exposed to lactic acid and roughened to mimic the apical resorption. Group V: apical treatment done same as Group IV and root-end filling done using mineral trioxide aggregate (MTA). Apical one-third of all samples immersed in Adhesion and penetration was observed in Group IIIa and Group IV. Only adhesion in Group II and IIIB and no adhesion and penetration in Group I and V.Adhesion and penetration of
PubMed | Hke Societys S Nijalingappa Institute Of Dental Science And Research, Bharati Vidyapeeth Deemed University, AMEs Dental College and Hospital, Indira Gandhi Institute of Dental science and Al Badar Rural Dental College and Hospital
Type: Journal Article | Journal: Journal of Indian Society of Periodontology | Year: 2015
The dimensions of dentogingival junction have been evaluated from autopsy jaw specimens. Previous studies demonstrated variability in histologic biologic width (BW) in periodontal health and mild periodontitis. Few studies have been done on the measurement of clinical BW in periodontitis. BW variation provides implications for selection of surgical or nonsurgical approaches. The purpose of this study was to determine clinical BW in periodontal health and chronic generalized periodontitis and to compare it with histologic dimensions of BW.A total of 20 subjects with chronic generalized periodontitis and 20 subjects with healthy periodontium were included in the present study. Plaque index and community periodontal index of treatment needs were scored; moreover, probing depth (PD) and clinical attachment level were measured. Full mouth intraoral periapical radiographs were taken, and digitalized images were obtained to measure the crestal bone level using computerized software.Clinical BW was significantly greater in both healthy and periodontitis groups than previously reported histologic BW of 2.04 mm (P < 0.001). The mean clinical BW was 3.98 mm.Mean clinical BW in both groups was significantly greater than histologic BW and sites with shallow PDs demonstrated greatest BW, suggesting that these sites may be at increased risk for losing significant attachment during surgical procedures.
PubMed | Al Badar Rural Dental College and Hospital, College of St. Joseph and Narayana Dental College and Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016
Orthodontists are commonly faced with the decision of what to do with loose brackets, and with inaccurately located brackets that need repositioning during treatment. One solution is to recycle the brackets. The potential effects of reconditioning a bracket are dependent upon many factors which may result in physical changes like alteration in slot tolerance, which may influence sliding mechanics by affecting frictional resistance.To study and compare the dimensional changes in the bracket slot width and depth in reconditioned brackets from unused brackets under scanning electronic microscope and to study and compare any consequent effects on the static frictional resistance of stainless steel brackets after reconditioning and in unused brackets.Dentarum manufactured 90 stainless steel central incisors edgewise brackets of size 0.22 X 0.030 inch and 0 tip and 0angulation were taken. 60 samples for measuring frictional resistance and 30 samples for measuring slot dimensions. Ortho organizers manufactured stainless steel arch wires 0.019 X 0.025 straight lengths 60 in number were considered for measuring static frictional resistance.The mean slot width and depth of new brackets were 0.0251 and 0.0471, which exceeded the manufacturers reported nominal size of 0.022 X 0.030, by 0.003 and 0.017. The reconditioned brackets demonstrated a further increase in mean slot width and depth to 0.028 and 0.0518 that is by 0.0035 and 0.0047 which is statistically significant (p=0.001, 0.002). The mean static frictional forces of the reconditioned brackets was nearly similar to that of new brackets that is 0.3167N for reconditioned brackets and 0.2613 N for new brackets.Although the reconditioning process results in physical changes to bracket structure this does not appear to result in significant effect on ex-vivo static frictional resistance.