Al Andalus University for Medical Sciences
Al Qadmus, Syria

Al-Andalus University for Medical science is a private university based in Qadmus, Syria. Established in 2005. The university specializes in medical science, and runs a number of training hospitals around the country. Currently the university has four faculties, Faculty of Dentistry, Faculty of Medicine,Faculty of Medical Engineering and Faculty of Pharmacy. Other planned faculties include Faculty of Nursing. Wikipedia.

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Zam W.,Al Andalus University for Medical Sciences
Progress in Nutrition | Year: 2016

Polyphenols were extracted from Pomegranate peels and then encapsulated by ionic gelation. The aqueous extract and the microbeads were used for the preparation of fortified milk. All beverages were kept in refrigerator and the shelf life of milk in terms of polyphenols content was studied. Results showed that 62.23% of polyphenols remained stable for 11 days in milk fortified with alginate-pectin (2:1) microbeads, while only 38.13% and 5.47% of polyphenols remained stable in milk fortified with sodium alginate microbeads and aqueous extract, respectively. Results also suggest that the formation of milk protein-polyphenol complexes compromises the antioxidant potential of the beverage. © Mattioli 1885.

Zam W.,Al Andalus University for Medical Sciences | Khadour A.,Al Andalus University for Medical Sciences
Nutrition and Cancer | Year: 2017

Cancer remains one of the leading causes of death around the world. Initially it is recognized as a genetic disease, but now it is known to involve epigenetic abnormalities along with genetic alterations. Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression. It includes changes in DNA methylation, histone modifications, and RNA interference. Although it is heritable, environmental factors such as diet could directly influence epigenetic mechanisms in humans. This article will focus on the role of dietary patterns and phytochemicals that have been demonstrated to influence the epigenome and more precisely histone and non-histone proteins modulation by acetylation that helps to induce apoptosis and phosphorylation inhibition, which counteracts with cells proliferation. Recent developments discussed here enhance our understanding of how dietary intervention could be beneficial in preventing or treating cancer and improving health outcomes. © 2017 Taylor & Francis Group, LLC.

Al-Kayali R.,University of Aleppo | Kitaz A.,University of Aleppo | Haroun M.,Al Andalus University for Medical Sciences
International Journal of Pharmacognosy and Phytochemical Research | Year: 2016

Objective: the present study aimed at evaluation of antibacterial activity of wild local Asphodelus microcarpus and Asphodeline lutea against methicillin resistant Staphylococcus aureus (MRSA) isolates. Methods: Antimicrobial activity of the crude extracts was evaluated against MRSA clinical isolates using agar wells diffusion. Determination of minimum inhibitory concentration(MIC)of methanolic extract of two studied plants was also performed using tetrazolium microplate assay. Results: Our results showed that different extracts (20 mg/ml) of aerial parts and bulbs of the studied plants were exhibited good growth inhibitory effect against methicilline resistant S. aureus isolates and reference strain. The inhibition zone diameters of A. microcarpus and A. lutea ranged from 9.3 to 18.6 mm and from 6.6 to 15.3mm respectively. All extracts have better antibacterial effect than tested antibiotics against MRSA isolate. The MIC of the methanolic extracts of A. lutea and A. microcarpus for MRSA fell in the range of 0.625 to 2.5 mg/ml and of 1.25-5 mg/ml, respectively. conclusion: The extracts of A. lutea and A. microcarpus could be a possible source to obtain new antibacterial to treat infections caused by MRSA isolates. Further studies on isolation of phyto-constituents and both in vitro and in vivo evaluation of pharmacological activities of isolated bioactive constituents of the crude extracts are recommended as future works. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.

Le Bideau F.,University Paris - Sud | Kousara M.,University Paris - Sud | Kousara M.,Al Andalus University for Medical Sciences | Chen L.,University Paris - Sud | And 2 more authors.
Chemical reviews | Year: 2017

The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic sesquiterpene compounds are reviewed from the pioneering results to the end of 2015. Their total syntheses with a particular emphasis on the first syntheses, enantiomeric versions, and syntheses that led to the revision of structures or stereochemistries are summarized. Overall, 284 tricyclic compounds are classified into fused, bridged, and miscellaneous structures based on 54 different skeletal types. Tricyclic sesquiterpenes constitute an important group of natural products. Their structural diversity and biological activities have generated further interest in the field of drug discovery research, although the exact mechanisms of action of these species are not well known. Furthermore, these tricyclic structures, according to their chemical complexity, are a source of inspiration for chemists in the field of total synthesis for the development of innovative methodologies.

Al Nashar A.,Al Andalus University for Medical Sciences | Yakoob H.,Al Andalus University for Medical Sciences
International Journal of Oral and Maxillofacial Surgery | Year: 2015

This study was conducted to evaluate the use of plasma rich in growth factors (PRGFs) with immediate implant placement in periodontally compromised extraction sites. Fifteen patients with chronic periodontitis were included. Each received two implants placed immediately after extraction in the anterior region of the mandible. One of the two implants was treated with PRGFs (group I), while the other was not and served as a control (group II). Implant survival, plaque index (PI), bleeding index (BI), probing pocket depth (PPD), and marginal bone loss (MBL) were evaluated for both groups. Complete soft tissue healing occurred in all patients and all implants were successfully osseointegrated over 12 months. At 12 months, results showed mean PPD values of 3.8 ± 0.3 mm at the control site (group II) and 3.4 ± 0.4 mm at the test site (group I); the mean MBL values were 1.1 ± 0.1 mm at the control site and 0.6 ± 0.1 mm at the test site. There were no statistically significant differences between the test and control groups regarding PI or BI, while there were statistical differences between the test and control groups regarding PPD and MBL throughout the follow-up period. © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Azrak S.,Al Andalus University for Medical Sciences
Biochemical Genetics | Year: 2015

Large insertions/deletions mutations are frequently found in genes associated with certain diseases such as hereditary cancers. These mutations are mostly overlooked by current classical screening techniques due to their certain limitations. This justifies the need to improve the existing techniques or design novel ones. A modified version of quantitative multiplex PCR short fluorescent fragment (QMPSF), termed universally primed QMPSF (upQMPSF), was developed. The modifications enhance multiplexing capacity, reduce cost, and improve the mutation detection spectrum. upQMPSF was used to screen germline mutations in 88 familial ovarian cancer patients negative for point mutations. upQMPSF successfully detected a 2.8 kb copy number gain spanning exon 15 of BRCA1 gene mediated by Alu–Alu homologous-based recombination. upQMPSF is a cost-efficient, versatile method, and demonstrated efficiency in detecting structural variations as a potential method for genetic testing in clinical and research laboratories. © 2015, Springer Science+Business Media New York.

Massoud S.,Al Andalus University for Medical Sciences
Journal of Chemical and Pharmaceutical Sciences | Year: 2015

A method was designed for the determination the amount of nickel in bronze. It was based on the adsorption of nickel on positive ion exchange of strong acid Amberlit CG-120 in form-H. HCl:acetone medium at pH=1 was used in order to separate other positive ions as chloride complexes. The fluids were filtered and the cation exchanger was treated with ammonium buffer solution pH=8-9, then it was treated with an ethanolic solution of Dimethylglyoxime. The determination of Nickel content was carried out using a spectrophotometer. Results indicated a content of 0.29±0.02%, whereas the nickel theoretical content was 0.31%. Using IR spectra, it was found that the adsorption of nickel on Amberlit CG-120 was due to covalent bonds with groups-SO3-, in the form of ammonium complexes. © 2015, SPB Pharma Society. All rights reserved.

Kheirallah M.,Al Andalus University for Medical Sciences | Almeshaly H.,Majmaah University
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology | Year: 2016

Objective: The purpose of this review is to discuss the dosage, duration and carrier for simvastatin, and to summarize effects of topical application directly or indirectly for stimulating bone regeneration. Methods: We have searched in Pubmed using keywords, simvastatin, dose response, bone regeneration, controlled-release delivery system. This search was complemented with a manual search of the relevant articles cited among the selected papers. The search was among the articles written in English and published in the last 10 years. The articles were revised in depth, and summarized. Results: High dose of simvastatin increases bone formation and resorption, while low dose of simvastatin decreases bone formation and increases bone resorption, furthermore it is reported that high dose of systemic administration of simvastatin will raise the risk of liver failure, kidney disease, and other side effects. Local administration can bypass hepatic degradation of statins to achieve therapeutic concentrations in bone and avoid the systemic side effects. The choice of appropriate carrier will depend on the release kinetics determined to be the best for osteogenesis. Conclusion: Local delivery of simvastatin from carriers appears to be an attractive solution to the problem of maintaining therapeutic doses to treat severe bone defects and to minimize the undesired side effects. Locally delivered simvastatin can increase the bone formation and accelerate healing process of bony defect. Another advantage of local delivery system is that it can stimulate new bone formation in a dose-dependent manner. Further evidence-based studies will be required to determine local delivery concentrations to promote bone regeneration. © 2015 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI.

Ibraheem I.,Al Andalus University for Medical Sciences
Skin Research and Technology | Year: 2015

Background: Melanoma is a leading fatal illness responsible for 80% of deaths from skin cancer. It originates in the pigment-producing melanocytes in the basal layer of the epidermis. Melanocytes produce the melanin (the dark pigment), which is responsible for the color of skin. As all cancers, melanoma is caused by damage to the DNA of the cells, which causes the cell to grow out of control, leading to a tumor, which is much more dangerous if it cannot be found or detected early. Only biopsy can determine exact malformation diagnosis, although it can rise metastasizing. When a melanoma is suspected, the usual standard procedure is to perform a biopsy and to subsequently analyze the suspicious tissue under the microscope. Methods: In this paper, we provide a new approach using methods known as 'imaging spectroscopy' or 'spectral imaging' for early detection of melanoma using two different supervised classifier algorithms, maximum likelihood (ML) and spectral angle mapper (SAM). SAM rests on the spectral 'angular distances' and the conventional classifier ML rests on the spectral distance concept. Results and conclusions: The results show that the ML classifier was more efficient for pixel classification than SAM. However, SAM was more suitable for object classification. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Aboutabikh K.,Al Andalus University for Medical Sciences | Aboukerdah N.,Al Andalus University for Medical Sciences
Computers in Biology and Medicine | Year: 2015

In this paper, we propose a practical way to synthesize and filter an ECG signal in the presence of four types of interference signals: (1) those arising from power networks with a fundamental frequency of 50. Hz, (2) those arising from respiration, having a frequency range from 0.05 to 0.5. Hz, (3) muscle signals with a frequency of 25. Hz, and (4) white noise present within the ECG signal band. This was done by implementing a multiband digital filter (seven bands) of type FIR Multiband Least Squares using a digital programmable device (Cyclone II EP2C70F896C6 FPGA, Altera), which was placed on an education and development board (DE2-70, Terasic). This filter was designed using the VHDL language in the Quartus II 9.1 design environment. The proposed method depends on Direct Digital Frequency Synthesizers (DDFS) designed to synthesize the ECG signal and various interference signals. So that the synthetic ECG specifications would be closer to actual ECG signals after filtering, we designed in a single multiband digital filter instead of using three separate digital filters LPF, HPF, BSF. Thus all interference signals were removed with a single digital filter. The multiband digital filter results were studied using a digital oscilloscope to characterize input and output signals in the presence of differing sinusoidal interference signals and white noise. © 2015 Elsevier Ltd.

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