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Al Qadmus, Syria

Al-Andalus University for Medical science is a private university based in Qadmus, Syria. Established in 2005. The university specializes in medical science, and runs a number of training hospitals around the country. Currently the university has four faculties, Faculty of Dentistry, Faculty of Medicine,Faculty of Medical Engineering and Faculty of Pharmacy. Other planned faculties include Faculty of Nursing. Wikipedia.

Abd-Almajeed A.,Al Andalus University for Medical Sciences | Langevin F.,Compiegne University of Technology
Magnetic Resonance Imaging | Year: 2015

Purpose: 1H MRS typical studies lead to low-resolution maps (voxels size>1cm3). The low-resolution maps may involve the presence of two or more different tissues in a single voxel which gives partial volume effects. Such insufficient spatial resolution remains an obstacle for most routine clinical examinations and restricts the ability in the detection of small lesions. Materials and methods: The proposed algorithm is based on the combination of three ideas: controlled sub-pixel shift, averaging, and initial pixel size reduction until the spectrum extinction because initial pixel size will determine the final spatial resolution. Frequency range limits are studied to determine the optimal window of spectral peak (WSP). This method is validated in-vitro and in-vivo. Results: The results in-vitro allowed us to consolidate the theoretical one. Results in-vivo are compared with the clinical protocol to demonstrate the increase in spatial resolution. The proposed method allowed us to reduce the pixel size to1/16 of its initial pixel size in total scan time (TS) of 17. min 10. s. We demonstrated that the optimal WSP is 80% of its initial value and the interpolation "Bilinear" has the minimum error. Conclusion: A novel approach is established for processing images and reconstructing high-resolution map from low-resolution maps. We have presented a robust algorithm for high spatial resolution in-vivo 1H MRS, and have achieved a super spatial resolution up to 0.034cm3 to overcome the major technical challenges. © 2015 Elsevier Inc.

Kheirallah M.,Al Andalus University for Medical Sciences | Almeshaly H.,Majmaah University
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology | Year: 2016

Objective: The purpose of this review is to discuss the dosage, duration and carrier for simvastatin, and to summarize effects of topical application directly or indirectly for stimulating bone regeneration. Methods: We have searched in Pubmed using keywords, simvastatin, dose response, bone regeneration, controlled-release delivery system. This search was complemented with a manual search of the relevant articles cited among the selected papers. The search was among the articles written in English and published in the last 10 years. The articles were revised in depth, and summarized. Results: High dose of simvastatin increases bone formation and resorption, while low dose of simvastatin decreases bone formation and increases bone resorption, furthermore it is reported that high dose of systemic administration of simvastatin will raise the risk of liver failure, kidney disease, and other side effects. Local administration can bypass hepatic degradation of statins to achieve therapeutic concentrations in bone and avoid the systemic side effects. The choice of appropriate carrier will depend on the release kinetics determined to be the best for osteogenesis. Conclusion: Local delivery of simvastatin from carriers appears to be an attractive solution to the problem of maintaining therapeutic doses to treat severe bone defects and to minimize the undesired side effects. Locally delivered simvastatin can increase the bone formation and accelerate healing process of bony defect. Another advantage of local delivery system is that it can stimulate new bone formation in a dose-dependent manner. Further evidence-based studies will be required to determine local delivery concentrations to promote bone regeneration. © 2015 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI.

Massoud S.,Al Andalus University for Medical Sciences
Journal of Chemical and Pharmaceutical Sciences | Year: 2015

A method was designed for the determination the amount of nickel in bronze. It was based on the adsorption of nickel on positive ion exchange of strong acid Amberlit CG-120 in form-H. HCl:acetone medium at pH=1 was used in order to separate other positive ions as chloride complexes. The fluids were filtered and the cation exchanger was treated with ammonium buffer solution pH=8-9, then it was treated with an ethanolic solution of Dimethylglyoxime. The determination of Nickel content was carried out using a spectrophotometer. Results indicated a content of 0.29±0.02%, whereas the nickel theoretical content was 0.31%. Using IR spectra, it was found that the adsorption of nickel on Amberlit CG-120 was due to covalent bonds with groups-SO3-, in the form of ammonium complexes. © 2015, SPB Pharma Society. All rights reserved.

Albougha S.,Damascus University | Darwich K.,Damascus University | Darwich M.A.,Al Andalus University for Medical Sciences | Albogha M.H.,Kyushu University | Albogha M.H.,Damascus University
International Journal of Oral and Maxillofacial Surgery | Year: 2015

In this study, finite element analysis (FEA) was used to evaluate nine rigid internal fixation techniques for sagittal split ramus osteotomy. To achieve this, a computed tomography (CT) scan of a healthy patient was obtained and used to generate the geometry of a half-mandible. The geometries of bicortical screws, miniplates, and monocortical screws were designed and combined with the mandible in nine models simulating various techniques. Four models used bicortical screws in various arrangements and four used miniplates of various designs. One model represented a hybrid technique. A load of 500 N was applied to the posterior teeth and FEA was applied. The most stable techniques were the hybrid technique and a single straight miniplate, presenting the least displacement among all models. Bicortical screws, while presenting reasonable stability, showed high strain areas near the anterior ramus ridge, superoposterior to the screws, implying a risk of bone fracture in this area. On the other hand, the T-shaped and double Y-shaped miniplates were associated with high von Mises stresses that would impair their rigidity, especially where angles appeared in their designs. We recommend the use of a single straight miniplate because it provides sufficient stable fixation with minimal risks or disadvantages. © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Azrak S.,Al Andalus University for Medical Sciences
Biochemical Genetics | Year: 2015

Large insertions/deletions mutations are frequently found in genes associated with certain diseases such as hereditary cancers. These mutations are mostly overlooked by current classical screening techniques due to their certain limitations. This justifies the need to improve the existing techniques or design novel ones. A modified version of quantitative multiplex PCR short fluorescent fragment (QMPSF), termed universally primed QMPSF (upQMPSF), was developed. The modifications enhance multiplexing capacity, reduce cost, and improve the mutation detection spectrum. upQMPSF was used to screen germline mutations in 88 familial ovarian cancer patients negative for point mutations. upQMPSF successfully detected a 2.8 kb copy number gain spanning exon 15 of BRCA1 gene mediated by Alu–Alu homologous-based recombination. upQMPSF is a cost-efficient, versatile method, and demonstrated efficiency in detecting structural variations as a potential method for genetic testing in clinical and research laboratories. © 2015, Springer Science+Business Media New York.

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