Buntzel J.,Head & Neck Surgery |
Buntzel J.,AKTE Study Group |
Buntzel H.,Nordhausen Municipal Hospital |
Micke O.,AKTE Study Group |
And 6 more authors.
Trace Elements and Electrolytes | Year: 2014
Objective: What is the impact of preconditioning nutritional support on the clinical course of irradiation because of advanced head and neck cancer? Methods: We administered 1,000 kcal IV per day for about 2 weeks and compared the effects on radiotherapy course (breaks, duration) by matched pair analysis to control subjects. 20 risk patients were treated with nutritional support (10 definitive radiotherapy, and 10 adjunctive radiotherapy). The control group included 20 patients with equivalent age, gender, tumor stage and localization, as well as type of RT. A risk patient was identified by bioimpedance analysis. A BIA phase angle < 4.0 (or < 5.0) is associated with a high risk for malnutrition in patients at the age > 60 years (or < 60 years). Results: Interruptions of radiotherapy were seen in 0 patients of nutritional support group versus 3 patients of the control group (p = 0.115). The duration of radiotherapy was 51 days in pretreated patients versus 55 days in control subjects (p = 0.096). The grade 3 or 4 toxicities (RTOG) were decreased from 8 patients in the control group to 2 patients in the pretreated group (p = 0.028). Conclusion: The results of this pilot study show a positive effect of early nutritional support on the course of radiotherapy. The nutritional therapy should be additionally administered to the normal oral feeding. ©2014 Dustri-Verlag Dr. K. Feistle ISSN 0946-2104. Source