Bielefeld, Germany
Bielefeld, Germany
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Kisters K.,St Anna Hospital | Al-Tayar H.,St Anna Hospital | Nguyen M.Q.,St Anna Hospital | Liebscher H.,SHO Mineralimbalancen | And 5 more authors.
Trace Elements and Electrolytes | Year: 2011

A magnesium deficiency is known to be involved in the pathogenesis of primary hypertension. In patients with essential hypertension intima media thickness is increased in about 70% (ELSA Study). In our study, we investigated 21 patients (10 female, 11 male, average age 56.3 ± 6.6 years) with untreated essential hypertension (Grades I and II according to WHO guidelines). All patients had a hypomagnesemia in serum (1.57 ± 0.11 mg%). In all patients we found a significant increase in intima media thickness of arteria carotis communis (0.97 ± 0.08 mm) (r = -0.869, p < 0.0001). The results show that a magnesium deficiency in patients with essential hypertension may be of special pathogenetic importance. In addition, the role of magnesium deficiency in the development of arteriosclerosis has to be discussed. Furthermore, we demonstrated a connection between magnesium deficiency and an increased intima media thickness. In this context, calcium antagonist therapy or magnesium supplementation may be of advantage when treating intima media thickness in hypertension. ©2011 Dustri-Verlag Dr. K. Feistle.

Kisters K.,St Anna Hospital | Cziborra M.,St Anna Hospital | Funke C.,St Anna Hospital | Kozianka J.,St Anna Hospital | And 9 more authors.
Nieren- und Hochdruckkrankheiten | Year: 2010

Magnesium is an essential electrolyte in living organisms, which has to be substituted in a sufficient amount. The clinical importance of a magnesium overload or a magnesium intoxication is seldom. However, a magnesium deficiency is of special importance in humans, despite of a normal magnesium supplementation. The primary effect of a magnesium deficiency results in a reduction of several enzyme activities in metabolism and energy production. The reduced energy production can result in a disturbed membrane function, calcium magnesium antagonism and cell dysfunction. Thereby consequences may result in an organ dysfunction and an altered answer to external and internal stress. The reduced energy status is responsible for the recovery of unhealthy individuals, e.g. cardiac arrhythmias, primary hypertension, pre-eclampsia, cramps, allergic reactions etc. The special importance of an oral or intravenously supplementation of magnesium has often been discribed in a variety of diseases. In addition of special interest is the use of magnesium in critically ill patients in intensive care medicine. © 2010 Dustri-Verlag Dr. Karl Feistle.

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