Antalya, Turkey
Antalya, Turkey

Akdeniz University is a campus university in Antalya Province of Turkey. It is the leading higher education and scientific research center of the West Mediterranean region of Turkey. Wikipedia.

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Ozben T.,Akdeniz University
Current Topics in Medicinal Chemistry | Year: 2015

Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death. Antioxidant supplements are consumed widely by cancer patients in order to prevent toxic side effects of cancer treatment to normal tissues and organs. However, the effects of antioxidant supplementation in cancer therapy were largely disappointing. There is still no consensus on the efficacy and safety of dietary antioxidant supplementation during conventional cancer therapy. In some studies, antioxidant supplements did not reduce the risk for cancer or prevent tumour growth; at the contrary, these interventions resulted in some cases to be harmful to the patients. Therefore, a guidance on antioxidant supplementation based on large clinical trials is urgently needed in order to obtain the best possible care and to avoid risky treatments for cancer patients. © 2015 Bentham Science Publishers.

Camurlu P.,Akdeniz University
RSC Advances | Year: 2014

Electrochromic materials display a reversible color change upon electrochemical cycling. In the last two decades there has been increasing interest in the electrochromic properties of polypyrroles. In this article, we highlight and provide insight into the electrochromic properties of polypyrroles in terms of their structure-property relationships without the intention of providing a complete chronological order. © The Royal Society of Chemistry 2014.

In this paper, nonlinear dynamic response of rectangular laminated composite plate resting on nonlinear Pasternak type elastic foundations is investigated. First-order shear deformation theory (FSDT) is used for modeling of moderately thick plates. The plate formulation is based on the von Karman nonlinear equation. The resulting nonlinear governing equations for transient analysis of laminated plates on elastic foundation are integrated using the discrete singular convolution-differential quadrature coupled approaches. The nonlinear governing equations of motion of plate are discretized in space and time domains using the discrete singular convolution and the differential quadrature methods, respectively. The validity of the present method is demonstrated by comparing the present results with those available in the open literature. The effects of the foundation parameters, boundary conditions and geometric parameters of plates on nonlinear dynamic response of laminated thick plates are investigated. © 2013 Elsevier Ltd. All rights reserved.

Free vibration analysis of laminated conical shells is presented by using the numerical solution of governing differential equations of motion based on transverse shear deformation theory. Results are presented for isotropic, orthotropic, and laminated cases for conical shells. Free vibrations of circular cylindrical shells and annular plates are treated as special cases. To verify the accuracy of this method, comparisons of the present results are made with results available in the open literature. Numerical results in vibrations of laminated conical shells are presented for different geometric and material parameters. © 2012 Elsevier Ltd. All rights reserved.

Kucukakca Y.,Akdeniz University
European Physical Journal C | Year: 2013

In this paper, in the framework of teleparallel gravity we consider scalar tensor theories of gravity in which scalar field is non-minimal coupled to torsion scalar. Noether symmetry of the Lagrangian of such a theory for the Friedmann-Robertson-Walker space-time is used to determine the explicit forms for the coupling function and for the potential, and it is shown that both must be power-law forms as a functions of the scalar field. The solutions of the field equations for the considered models are presented by using the results obtained from the Noether symmetry. It is shown that the equation of state parameter in the present model can cross the phantom divide line for a special case with the coupling function F(φ{symbol}) = 3/16φ{symbol}2 and for the potential V(φ{symbol})=λφ{symbol}2. © 2013 Springer-Verlag Berlin Heidelberg and Società Italiana di Fisica.

Ozkan O.,Akdeniz University
Fertility and sterility | Year: 2013

To demonstrate the technique for uterus retrieval and transplantation from a multiorgan donor. Video presentation of our case report. The video uses animation to demonstrate the technique. Institutional Review Board (IRB) approval was obtained. University hospital. A 21-year-old woman with complete müllerian agenesis. Uterus allotransplantation has been performed from a deceased donor. Acquirement of cyclic menstrual function. This video demonstrates the technique for uterus retrieval, perfusion, and transplantation. The recipient patient has been monitored regularly for vascular flow, immunosuppression, and infection control since the operation. Uterus transplantation requires extensive evaluation of the recipient and donor by an experienced multidisciplinary transplantation team both pre- and postoperatively. It has major risks related to surgery, immunosuppression, and pregnancy. Uterus transplantation might be considered promising only after the birth of a near-term healthy baby. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Gungor A.,Akdeniz University
Energy Conversion and Management | Year: 2013

In this study, the effect of the biomass share on CO, NOx and SO2 emissions are investigated to reveal the benefits of co-firing biomass and coal in CFBs by using a developed model. The results are compared with two published comprehensive data sets. The results show that CO, NO x and SO2 emissions decrease as the biomass share increases for industrial scale CFB combustors. © 2012 Elsevier Ltd. All rights reserved.

Elpek G.O.,Akdeniz University
World Journal of Gastroenterology | Year: 2014

There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate that the termination of fibrogenic processes and the restoration of deficient fibrolytic pathways may allow the reversal of advanced fibrosis and even cirrhosis. Therefore, efforts have been made to better clarify the cellular and molecular mechanisms that are involved in liver fibrosis. Activation of hepatic stellate cells (HSCs) remains a central event in fibrosis, complemented by other sources of matrix-producing cells, including portal fibroblasts, fibrocytes and bone marrow-derived myofibroblasts. These cells converge in a complex interaction with neighboring cells to provoke scarring in response to persistent injury. Defining the interaction of different cell types, revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in activated HSCs will enable the discovery of new therapeutic targets. Moreover, the characterization of different pathways associated with different etiologies aid in the development of disease-specific therapies. This article outlines recent advances regarding the cellular and molecular mechanisms involved in liver fibrosis that may be translated into future therapies. The pathogenesis of liver fibrosis associated with alcoholic liver disease, non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms involved in liver fibrosis. © 2014 Baishideng Publishing Group Inc. All rights reserved.

Erkan N.,Akdeniz University
Food Chemistry | Year: 2012

Portulaca oleracea fractions obtained from the crude extract of the plant by reversed-phase separation were investigated for their antioxidant activities and phenolic compounds content. Five fractions were classified based on optical absorption between the wavelength range of 200-400 nm. Fraction 3 displayed higher absorption than the other fractions. The total amount of quantified phenolics in this fraction was found to be quite high compared to that of crude extract. Chlorogenic, caffeic, p-coumaric, ferulic and rosmarinic acids were the free phenolic acids, and quercetin and kaempferol were the free flavonoids detected in Fraction 3. IC 50 value of crude extract was found to be 511.8 μg/ml whereas Fraction 3 exhibited an IC 50 value of 154.1 μg/ml. TEAC of Fraction 3 was found to be almost four times higher than that of the crude extract. Fraction 3 was also found to show the highest lipid peroxidation inhibiting capacity, determined by TBARS assay. © 2012 Elsevier Ltd. All rights reserved.

We present a detailed analysis of the 6He elastic scattering on different target nuclei over a wide energy range within the framework of the double folding model using a phenomenological imaginary potential. We show the microscopic real potential generated by No-core Shell model density distributions provides good agreement in explaining the elastic scattering angular distributions. In this study we also present a new formulation depending on the incident energy and atomic charge of the target nucleus for the phenomenological imaginary potential and investigate the threshold anomaly in halo nuclei by analyzing the 6He + 208Pb system. © 2014 Elsevier B.V.

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