Tsunemoto H.,Aizawa Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2016
Single coronary artery is rear. Various combination anomalies have been reported in patients with this anomaly undergoing heart surgery. We report a case of annuloaortic ectasia combined with single coronary artery and ventricular septal defect. The patient was a 67-year-old man with exertional dyspnea. Coronary angiography and computed tomography revealed a single coronary artery. Aortography showed severe aortic regurgitation and dilatation of Valsalva sinus. Ultrasonic cardiography showed small ventricular septal defect at the membranous septum. He underwent Modified Bentall's operation. He recovered without any complications. An annuloaortic ectasia associated with single coronary and ventricular septal defect is a very rare combination.
News Article | May 9, 2017
Asia Proton Therapy Market (Actual & Potential), Patients Treated, List of Proton Therapy Centers and Forecast to 2022 provides a comprehensive assessment of the fast-evolving, high-growth Proton Therapy Market. Asia proton therapy market is anticipated to almost three-fold during the period 2016 - 2022. The number of proton therapy centers is continuously increasing in Asia. Still, it is believed that players will miss out on a majority of cancer patients who can benefit with proton therapy, overlooking a huge multi-Billion-dollar potential market. The number of patients treated with Proton Therapy is very low whereas; the potential candidates for proton therapy are huge. Key Points Covered in the Report: - Asia accounts for around 60% of the world population and half the global burden of cancer. - Mitsubishi is the leading player in proton therapy market in Japan. However, other players like IBA, Hitachi, Sumitomo etc. have also started to make their presence felt in the market. - South Korea is the second largest market for proton therapy in Asia. - China has the huge market opportunity for proton therapy treatment owing to large population bae of cancer patients. - IBA has one operational proton therapy center in China while 4 more centers are in development phase. - In India, 2 proton therapy centers are under development phase and are scheduled to open in 2018 and 2019. Key Topics Covered: 1. Executive Summary 2. Asia Proton Therapy Market Analysis 2.1 Asia Proton Therapy Market - Actual and Potential Market 2.2 Asia Proton Therapy Patient Number - Actual and Potential 3. Asia Proton Therapy Market Share Analysis 3.1 Asia Proton Therapy Actual and Potential Market Share - By Country 3.2 Asia Proton Therapy Actual and Potential Candidate Share - By Country 4. Asia - List of Proton Therapy Centers, Start of Treatment, Patient Treated 5. Japan Proton Therapy Market Analysis 5.1 Japan Proton Therapy - Actual and Potential Market (2003 - 2022) 5.2 Japan Proton Therapy Patients Number - Actual and Potential (2003 - 2022) 5.3 Japan - List of Proton Therapy Centers, Cost, Start of Treatment, Patient Treated 5.4 Japan Proton Therapy - Company Analysis 6. Japan - Number of Patients Treated at Proton Therapy Centers 6.1 National Institute of Radiological Sciences - Number of Patients Treated (2008 - 2015) 6.2 Hyogo Ion Beam Medical Center - Number of Patients Treated (2007 - 2015) 6.3 Shizuoka Cancer Center - Number of Patients Treated (2007 - 2015) 6.4 Southern Tohoku Proton Therapy Center - Number of Patients Treated (2013 - 2014) 6.5 Gunma University Heavy Ion Medical Center - Number of Patients Treated (2013 - 2015) 6.6 Fukui Prefectural Hospital Proton Beam Cancer Treatment Center - Number of Patients Treated (2013 - 2015) 6.7 Medipolis Medical Research Institute - Number of Patients Treated (2013 - 2015) 6.8 Saga Heavy Ion Medical Accelerator in Tosu - Number of Patients Treated (2013 - 2015) 6.9 Japanese National Cancer Center - Number of Patients Treated (2007 - 2014) 6.10 The Proton Medical Research Center 2, University of Tsukuba, JAPAN - Number of Patients Treated (2007 - 2015) 6.11 Nagoya City Quality Life 21 Jouhoku, Japan - Number of Patients Treated (2013 - 2015) 6.12 Aizawa Hospital - Number of Patients Treated (Oct - 2014) 7. South Korea Proton Therapy Market Analysis 7.1 South Korea Proton Therapy - Actual and Potential Market (2007 - 2022) 7.2 South Korea Proton Therapy Patients Number - Actual and Potential (2007 - 2022) 7.3 South Korea - List of Proton Therapy Centers, Start of Treatment, Patient Treated 8. South Korea - Number of Patients Treated at Proton Therapy Centers 8.1 Korean National Cancer Center - Number of Patients Treated (2007 - 2015) 8.2 Samsung Proton Center - Number of Patients Treated (2015) 9. China Proton Therapy Market Analysis 9.1 China Proton Therapy - Actual and Potential Market (2014 - 2022) 9.2 China Proton Therapy Patients Number - Actual and Potential (2014 - 2022) 9.3 China - List of Proton Therapy Centers, Start of Treatment 10. China - Number of Patients Treated at Proton Therapy Centers 10.1 Wanjie Proton Therapy Center (WPTC) - Number of Patients Treated (2007 - 2013) 11. India Potential Proton Therapy Market Analysis (2009 - 2022) 11.1 India - Potential Proton Therapy Market and Forecast 11.2 India - Potential Candidate for Proton Therapy Number and Forecast 11.3 India - List of Proton Therapy Centers, Start of Treatment 12. Singapore Potential Proton Therapy Market Analysis (2012 - 2022) 12.1 Singapore - Potential Proton Therapy Market and Forecast 12.2 Singapore - Potential Candidate for Proton Therapy Number and Forecast 12.3 Singapore - List of Proton Therapy Centers, Start of Treatment 13. Taiwan Potential Proton Therapy Market Analysis (2012 - 2022) 13.1 Taiwan - Potential Proton Therapy Market and Forecast 13.2 Taiwan - Potential Candidate for Proton Therapy Number and Forecast 13.3 Taiwan - List of Proton Therapy Centers, Start of Treatment 14. Current Radiation Therapies 14.1 Third Dimensional Conformal Therapy (CRT) 14.2 Image Guided Radiotherapy (IGRT) 14.3 Intensity Modulated Radiotherapy (IMRT) 14.4 Stereotactic Radiotherapy 14.5 Neutron Therapy 14.6 Heavy Ion Radiotherapy 14.7 Proton Therapy 15. Components of a Standard Proton Therapy Center 15.1 Proton Accelerator 15.2 Beam Transport System 15.3 Beam Delivery System 15.4 Nozzle 15.5 Treatment Planning System 15.6 Image Viewers 15.7 Patient Positioning System (PPS) 15.8 Human Resource 16. Proton Therapy - Driving Factors 16.1 Technology Advancement 16.2 Growing Incidence of Cancer Patients 16.3 Proton Therapy Provides Enormous Benefits 17. Proton Therapy - Challenges 17.1 Requires Huge Investment 17.2 Operations Challenges 17.3 More Clinical Evidence Is Needed For more information about this report visit http://www.researchandmarkets.com/research/8hcbbg/asia_proton Research and Markets Laura Wood, Senior Manager email@example.com For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/asia-proton-therapy-market-report-2017-patients-treated-list-of-proton-therapy-centers-and-forecast-to-2022---research-and-markets-300454204.html
Urano M.,Aichi University |
Nagao T.,Tokyo Medical University |
Miyabe S.,Aichi Gakuin University |
Ishibashi K.,Aichi Gakuin University |
And 2 more authors.
Human Pathology | Year: 2015
Mammary analogue secretory carcinoma (MASC) is a recently recognized salivary gland tumor harboring an ETV6-NTRK3 translocation similar to secretory carcinoma of the breast. Histologically, MASC mimics papillary-cystic, microcystic, and follicular-type acinic cell carcinoma (AciCC) and low-grade cribriform cystadenocarcinoma (LGCCC) of the salivary gland. Using histology, immunohistochemistry (IHC), and molecular genetic techniques, we reevaluated 18 cases originally diagnosed as AciCC between 1993 and 2012. The last of these methods was used to detect the ETV6-NTRK3 translocation. The results reconfirmed 6 cases as AciCC (3 men; average age, 63 years) and helped us reclassify 10 cases as MASC (6 men; mean age, 46 years) and 2 as LGCCC (2 women; mean age, 48 years). Using IHC, we identified the 3 histologic types according to the expression patterns of vimentin, high-molecular-weight cytokeratin, cytokeratin 19, S-100, mammaglobin, MUC1, GATA-binding protein 3, adipophilin, α-amylase, DOG-1, SOX-10, and p63. The number of tumors diagnosed as MASC indicates that AciCC includes bona fide MASC cases. Because differential diagnosis among zymogen granule-poor AciCC, MASC, and LGCCC tumors is challenging, we recommend using molecular genetic tests for ETV6-NTRK3 for accurate diagnosis. Furthermore, detailed analyses of hematoxylin and eosin-stained tissues and IHC studies using the markers described here should be incorporated into routine practices. © 2014 Elsevier Inc.
Shiratsu K.,Shinshu University |
Shiratsu K.,Aizawa Hospital |
Higuchi K.,Aizawa Hospital |
Nakayama J.,Shinshu University
Cancer Science | Year: 2014
Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides having terminal α1,4-linked N-acetylglucosamine (αGlcNAc) residues largely attached to a MUC6 scaffold. Previously, we generated A4gnt-deficient mice, which totally lack αGlcNAc, and showed that αGlcNAc functions as a tumor suppressor for gastric cancer. Here, to determine the clinicopathological significance of αGlcNAc in gastric carcinomas, we examined immunohistochemical expression of αGlcNAc and mucin phenotypic markers including MUC5AC, MUC6, MUC2, and CD10 in 214 gastric adenocarcinomas and compared those expression patterns with clinicopathological parameters and cancer-specific survival. The αGlcNAc loss was evaluated in MUC6-positive gastric carcinoma. Thirty-three (61.1%) of 54 differentiated-type gastric adenocarcinomas exhibiting MUC6 in cancer cells lacked αGlcNAc expression. Loss of αGlcNAc was significantly correlated with depth of invasion, stage, and venous invasion by differentiated-type adenocarcinoma. Loss of αGlcNAc was also significantly associated with poorer patient prognosis in MUC6-positive differentiated-type adenocarcinoma. By contrast, no significant correlation between αGlcNAc loss and any clinicopathologic variable was observed in undifferentiated-type adenocarcinoma. Expression of MUC6 was also significantly correlated with several clinicopathological variables in differentiated-type adenocarcinoma. However, unlike the case with αGlcNAc, its expression showed no correlation with cancer-specific survival in patients. In undifferentiated-type adenocarcinoma, we observed no significant correlation between mucin phenotypic marker expression, including MUC6, and any clinicopathologic variable. These results together indicate that loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated, but not undifferentiated, types of gastric adenocarcinoma. Loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated but not undifferentiated types of gastric adenocarcinoma. © 2013 The Authors.
Yomo S.,Aizawa Hospital |
Hayashi M.,San ai Hospital
Journal of Neuro-Oncology | Year: 2013
The aim of the present study was to evaluate the efficacy and limitations of repeat stereotactic radiosurgery (SRS) salvage for patients with recurrence of brain metastases (BM) after whole brain radiotherapy (WBRT). This is a retrospective, observational, single-center trial analyzing 77 consecutive patients with recurrent BM who were treated primarily with WBRT. All patients underwent SRS as salvage treatment. Median age was 62 years, and median Karnofsky performance status (KPS) was 80. The median interval between the starting date of WBRT and radiosurgery was 10.6 months. One, two and more than two SRS sessions were required in 42, 13 and 22 patients, respectively. The median total planning target volume (PTV) was 8.1 mL and the median dose prescribed was 20 Gy. The median follow-up was 7.7 months. 1- and 2-year neurological death-free survival (NS) rates were 87 and 78 %, respectively. Competing risk analysis demonstrated active extra-central nervous system (CNS) disease [Hazard ratio (HR) 0.236, P = 0.041] and total PTV on initial SRS (≥5 mL) (HR 4.22, P = 0.033) to be associated with the NS rate. 1- and 2-year overall survival (OS) rates were 41 and 11 %, respectively. The median OS time was 8.2 months. Active extra-CNS disease (HR 1.94, P = 0.034) and high KPS (≥90) (HR 0.409, P = 0.006) were associated with the OS rate. In total, 798 tumors (75 %) in 66 patients (86 %) with sufficient radiological follow-up data were evaluated. 1- and 2-year metastasis local control rates were 76.6 and 57.9 %, respectively. Prescribed dose (≥20 Gy) (HR 0.326, P < 0.001), tumor volume (≥2 mL) (HR 1.98, P = 0.007) and metastases from breast cancer (HR 0.435, P < 0.001) were independent predictive factors for local tumor control. Repeat salvage SRS for recurrent BM after WBRT appeared to be a safe and effective treatment. In the majority of patients, even those with numerous BM, neurological death could be delayed or even prevented. © 2013 Springer Science+Business Media New York.
Yomo S.,Aizawa Hospital |
Hayashi M.,San ai Hospital
Radiation Oncology | Year: 2014
Background: Although the efficacy of prophylactic or therapeutic whole brain radiotherapy (WBRT) for brain metastases (BM) from small cell lung cancer (SCLC) is well established, the role of stereotactic radiosurgery (SRS) has yet to be determined. In the present retrospective analysis, we investigated whether upfront SRS might be an effective treatment option for patients with BM from SCLC.Methods: We analyzed 41 consecutive patients with a limited number of BM (≤ 10) from SCLC who received SRS as the initial treatment. No prophylactic and therapeutic WBRT was given prior to SRS. The median patient age was 69 years and the median Karnofsky performance status (KPS) score was 90. Repeat SRS was given for new distant lesions detected on follow-up neuroradiological imaging, as necessary. Overall survival, neurological death, and local and distant BM recurrence rates were analyzed. The survival results were tested with three prognostic scoring systems validated for SCLC: Diagnosis-specific graded prognostic assessment (DS-GPA), Radiation therapy oncology group -recursive partitioning analysis and Rades's survival score.Results: One- and 2-year overall survival rates were 44% and 17%, respectively. The median survival time was 8.1 months. Survival results replicated the DS-GPA (P = 0.022) and Rades's survival score (P = 0.034). On multivariate analysis, patients with high KPS (hazard ratio (HR): 0.308, P = 0.009) and post-SRS chemotherapy (HR: 0.324, P = 0.016) had better overall survival. In total, 95/121 tumors (79%) in 34 patients (83%) with sufficient radiological follow-up data were evaluated. Six- and 12-month rates of local control failure were 0% and 14%, respectively. Six- and 12-month distant BM rates were 22% and 44%, respectively. Repeat SRS, salvage WBRT and microsurgery were subsequently required in 18, 7 and one patient, respectively. Symptomatic radiation injury developed in two patients and both were treated conservatively.Conclusions: Our survival analyses with the validated prognostic grading systems suggested upfront SRS for limited BM from SCLC to be a potential treatment option, with patient survival being slightly more than eight months after SRS. Although SRS provided durable local tumor control, repeat treatment was needed in nearly half of patients to achieve control of distant BM. © 2014 Yomo and Hayashi; licensee BioMed Central Ltd.
Yomo S.,Aizawa Hospital |
Hayashi M.,San ai Hospital
Radiation Oncology | Year: 2014
Background: Large brain metastases (BM) remain a significant cause of morbidity and death for cancer patients despite current advances in multimodality therapies. The goal of the present study was to evaluate the efficacy and limitations of 2-session Gamma Knife stereotactic radiosurgery (SRS) for patients with large BM.Methods: This is a prospective, open-label and single arm study analyzing 58 consecutive patients who received 2-session SRS for large BM (≥ 10 mL). The median age was 66 years, and the median Karnofsky performance status (KPS) score was 70. SRS was the initial treatment in 51 large tumors (84%) and was used as salvage after failed prior treatments for 10 tumors (16%). The fraction protocol was 20-30 Gy given in 2 fractions with 3-4 weeks between fractions. Overall survival (OS) and neurological death (ND), local tumor control and KPS were analyzed.Results: The median follow-up time was 9.0 months. One- and 2-year OS rates were 47% and 20%, respectively. The median OS time was 11.8 months (95% CI: 5.5-15.6). The causes of death were intracranial local progression in 5 cases, meningeal carcinomatosis in 3 and progression of the primary lesion in 39. One- and 2-year ND-free survival rates were 91% and 84%, respectively. In 52 of 61 large BM (85%) with sufficient radiological follow-up data, 6- and 12-month local tumor control rates were 85% and 64%, respectively. The mean KPS improved from 70 at the 1st SRS to 82 at the 2nd; the first follow-up mean KPS was 87 (P < 0.001). Symptomatic radiation injury developed and required conservative treatment in 3 patients (5%).Conclusions: Long-term follow-up showed that two-session Gamma Knife SRS achieved durable tumor control rates as well as acceptable treatment-related morbidity. This treatment method may potentially merit being offered to patients with large BM who are in poor condition or are otherwise ineligible for standard care. © 2014 Yomo and Hayashi; licensee BioMed Central Ltd.
Nakasone Y.,Aizawa Hospital
European Journal of Clinical Nutrition | Year: 2016
Background/Objectives:The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM).Subjects/Methods:In 4234 subjects without diabetes, using logistic regression analysis with a 4.8-year follow-up period, we analyzed the relationship between (1) δBMI (BMIfollow-up−basal) and the progression from normal glucose regulation (NGR) to PDM or diabetes, and (2) δBMI and the regression from PDM to NGR.Results:Mean (±s.d.) δBMI was 0.17 (±1.3) kg/m2 in subjects with NGR and δBMI was positively and independently related to progression (adjusted odds ratio (ORadj) (95% CI), 1.24 (1.15–1.34), P<0.01). Mean (±s.d.) δBMI was −0.03 (±1.25) kg/m2 in those with PDM and δBMI was negatively related to the regression (ORadj, 0.72 (0.65–0.80), P<0.01). The relation of δBMI to the progression was significant in men (ORadj, 1.42 (1.28–1.59), P<0.01) but not in women (ORadj, 1.05 (0.94–1.19), P=0.36). Also, the negative impact of δBMI on the regression was significant only in men (men, ORadj, 0.65 (0.57–0.75), P<0.01; women, ORadj, 0.94 (0.77–1.14), P=0.51).Conclusions:In Japanese adults, an increase in the BMI by even 1 kg/m2 was related to 24% increase in the risk of development of PDM or diabetes in NGR subjects and was related to 28% reduction in the regression from PDM to NGR. In women, we did not note any significant impact of weight gain on the evolution or regression of PDM.European Journal of Clinical Nutrition advance online publication, 13 July 2016; doi:10.1038/ejcn.2016.118. © 2016 Macmillan Publishers Limited
Oguchi K.,Aizawa Hospital
Japanese Journal of Clinical Radiology | Year: 2015
We here report imaging characteristics of 7 patients with malignant lymphoma, in whom strong mesenteric uptake on FDG-PET/CT by apparently benign lesion was found shortly after the chemotherapy. As previously reported, we confirmed this lesion as fat necrosis. CT findings of mass are low-density, irregular-margin, and ill-defined. Elevated mesenteric fat density on pre-treatment CT is usually present in these patients, which help diagnose this condition.
Changes of TSH-stimulation blocking antibody (TSBAb) and thyroid stimulating antibody (TSAb) over 10 years in 34 TSBAb-positive patients with hypothyroidism and in 98 TSAb-positive graves patients with hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-receptor-antibody (TRAb)-positive patients
Takasu N.,Aizawa Hospital |
Matsushita M.,Aizawa Hospital
Journal of Thyroid Research | Year: 2012
Two TRAbs: TSBAb and TSAb. TSBAb causes hypothyroidism. TSAb causes Graves' hyperthyroidism. TSBAb and TSAb block TSH-binding to cells as TRAb, measured as TSH-binding inhibitory immunoglobulin (TBII). We reevaluate TSBAb and TSAb. We studied TSBAb, TSAb, and TBII over 10 years in 34 TSBAb-positives with hypothyroidism and in 98 TSAb-positives with hyperthyroidism. Half of the 34 TSBAb-positives with hypothyroidism continued to have persistently positive TSBAb, continued to have hypothyroidism, and did not recover from hypothyroidism. Ten of the 98 TSAb-positives with hyperthyroidism continued to have positive TSAb and continued to have hyperthyroidism. TSBAb had disappeared in 15 of the 34 TSBAb-positives with hypothyroidism. With the disappearance of TSBAb, recovery from hypothyroidism was noted in 13 (87%) of the 15 patients. TSAb had disappeared in 73 of the 98 TSAb-positives with hyperthyroidism. With the disappearance of TSAb, remissions of hyperthyroidism were noted in 60 (82%) of the 73. Two of the 34 TSBAb-positives with hypothyroidism developed TSAb-positive Graves' hyperthyroidism. Two of the 98 TSAb-positive Graves' patients with hyperthyroidism developed TSBAb-positive hypothyroidism. TSBAb and TSAb are TRAbs. TSBAb-hypothyroidism and TSAb-hyperthyroidism may be two aspects of one disease (TRAb disease). Two forms of autoimmune thyroiditis: atrophic and goitrous. We followed 34 TSBAb-positive patients with hypothyroidism (24 atrophic and 10 goitrous) over 10 years. All of the 10 TSBAb-positive goitrous patients recovered from hypothyroidism and 19 (79%) of the 24 TSBAb-positive atrophic patients continued to have hypothyroidism. © 2012 Nobuyuki Takasu and Mina Matsushita.