Aix-Marseille University is a public research university located in Provence, southern France. With roots dating back to 1409, the university was formed by the merger of the University of Provence, the University of the Mediterranean and Paul Cézanne University. The merger became effective on 1 January 2012, resulting in the creation of the largest university in France and the French-speaking world, with about 70,000 students. AMU has the largest financial endowment of any academic institution in the Francophone world, standing at €650 million.The university is organized around five main campuses situated in Aix-en-Provence and Marseille. Apart from its major campuses, AMU owns and operates facilities in Arles, Aubagne, Avignon, Digne-les-Bains, Gap, La Ciotat, Lambesc and Salon-de-Provence. The university is headquartered at the Pharo, Marseille.AMU has produced many notable alumni in the fields of law, politics, business, economics and literature. To date, there have been four Nobel Laureates amongst its alumni and faculty, as well as a two-time recipient of the Pulitzer Prize, three César Award winners, several heads of state, parliamentary speakers, government ministers, ambassadors and members of the Institut de France.AMU has hundreds of research and teaching partnerships, including close collaboration with the French National Centre for Scientific Research and the French Atomic Energy and Alternative Energies Commission . AMU is a member of numerous academic organisations including the European University Association and the Mediterranean Universities Union . Wikipedia.
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-01-11
The present invention relates to a compound of formula (I) or (II) and its use for detecting and/or quantifying a solvent S_(1) in a solvent S_(2), S_(1) and S_(2) being distinct:_(1), R_(2), R_(3), R_(4), R_(5), R_(6), X, Y and n are as defined in claim 1.
French Institute of Health, Medical Research and Aix - Marseille University | Date: 2015-12-15
The present invention relates to the general field of treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the treatment of immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.
Aix - Marseille University, French Institute of Health and Medical Research | Date: 2017-06-14
The present invention relates to an in vitro method for the prognosis and/or diagnosis of a pancreatic cancer comprising the detection of a BSDL gene with an apparent cytosine insertion in a patient sample.
French Institute of Health, Medical Research, Aix - Marseille University, Institute Jean Paoli & Irene Calmettes and French National Center for Scientific Research | Date: 2017-02-08
The present invention relates to methods for selecting binders by phage display and masked selection. More particularly, the present invention relates to a method for selecting a plurality of binders specific for at least one relevant target comprising screening a phage binder library of binders against the relevant target in presence of a plurality of binders obtained from a library of binders directed against at least one irrelevant target and positively selecting the binders that are specific for the at least one relevant target.
Aix - Marseille University and Assistance Publique Hopitaux De Marseille | Date: 2017-02-01
The present invention relates to antigen binding formats for use in therapeutic treatments or diagnostic assays. The present invention relates to an antigen-binding format consisting of:a first fusion protein wherein the CH1 constant domain of an antibody is fused i) by its N-terminal end to the C-terminal end of a variable domain of an antibody and ii) by its C-terminal end to the N-terminal end of a variable domain of an antibody and,a second fusion protein wherein the CL constant domain of an antibody is fused by its N-terminal end to the C-terminal end of a variable domain of an antibody.
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-04-26
This fluid dispenser with multiple fluid inlet/outlet channels (114A, 116A) comprises a first cylindrical portion (106), having at least one lateral fluid inlet or outlet channel, comprising at least one fluid connection chamber (146) for fluidly connecting said lateral channel to at least one opening formed in a lower base (110) of said first cylindrical portion (106). It comprises a second cylindrical portion (112), having several lateral fluid inlet/outlet channels (114A, 116A) and with circular cylindrical boring, having an upper base (110) coinciding with the lower base of the first cylindrical portion (106). It comprises a rotary circular cylindrical core (138), disposed inside the second cylindrical portion (112) and having an upper base in contact with the lower base (110) of the first cylindrical portion (106), free in rotation inside the second cylindrical portion (112) and in which there is formed at least one conduit (140, 142) for fluidly connecting said opening to at least any one of the lateral channels (114A, 116A) of the second cylindrical portion (112).
Aix - Marseille University and French National Center for Scientific Research | Date: 2017-05-03
The present invention relates to device for extraction of pollutants by multichannel tubular membrane containing at least one fluid channel allowing the fluid to go through a feed inlet to an outlet end characterized in that membrane comprises at least an extraction channel filled with molten salt in order to adsorb said pollutants having to be extracted from the said fluid. Advantageously, the membrane is a ceramic membrane. The invention will find an application for the treatment of traces of pollutants in a liquid or gaseous fluid. For example, the removal of small pollutants as volatile organic compounds from an aqueous stream in industrial wastewater treatment or other water treatment applications, or the separation of aromatic compounds form an hydrocarbon feed in petrochemical applications. The invention will also find application in the removal of water traces in products of high added value as pharmaceutical, cosmetic or biocarburant for example
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-04-18
The disclosure relates to a method for producing hydrogen gas and/or magnetite comprising the steps of reacting a wstite-containing material, such as steel slags, with H_(2)O at a temperature ranging from 150 C. to 500 C., cooling down the gaseous reaction product to separate hydrogen gas from water steam and collecting hydrogen gas, and recovering magnetite from the solid reaction product.
Aix - Marseille University, French Institute of Health and Medical Research | Date: 2017-03-20
The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.
Pellissier H.,Aix - Marseille University
Chemical Reviews | Year: 2013
Domino reactions are classified according to the mechanism of the individual steps, which may be of the same or different type. The quality and importance of a domino reaction can be correlated to the number of bonds generated in such a process and the increase in complexity. The concept of domino sequences has allowed easily reaching high molecular complexity with very often excellent levels of stereocontrol with simple operational procedures, as well as advantages of savings in solvent, time, energy, and costs. The use of one-component, two-component, and multicomponent domino reactions in asymmetric synthesis is increasing constantly. Such single-step reactions allow the synthesis of a wide range of structurally diverse and complex chiral molecules from simple substrates in an economically favorable manner by avoiding the use of costly and time-consuming protection deprotection processes, as well as purification procedures of intermediates.