Aix-Marseille University is a public research university located in Provence, southern France. With roots dating back to 1409, the university was formed by the merger of the University of Provence, the University of the Mediterranean and Paul Cézanne University. The merger became effective on 1 January 2012, resulting in the creation of the largest university in France and the French-speaking world, with about 70,000 students. AMU has the largest financial endowment of any academic institution in the Francophone world, standing at €650 million.The university is organized around five main campuses situated in Aix-en-Provence and Marseille. Apart from its major campuses, AMU owns and operates facilities in Arles, Aubagne, Avignon, Digne-les-Bains, Gap, La Ciotat, Lambesc and Salon-de-Provence. The university is headquartered at the Pharo, Marseille.AMU has produced many notable alumni in the fields of law, politics, business, economics and literature. To date, there have been four Nobel Laureates amongst its alumni and faculty, as well as a two-time recipient of the Pulitzer Prize, three César Award winners, several heads of state, parliamentary speakers, government ministers, ambassadors and members of the Institut de France.AMU has hundreds of research and teaching partnerships, including close collaboration with the French National Centre for Scientific Research and the French Atomic Energy and Alternative Energies Commission . AMU is a member of numerous academic organisations including the European University Association and the Mediterranean Universities Union . Wikipedia.
Aix - Marseille University | Date: 2015-03-10
The invention relates to a chimeric peptide displaying the ganglioside-binding properties of both -synuclein and -amyloid peptide. Such peptide is useful in preventing or treating any condition which involves gangliosides as cell surface receptor sites, including neurodegenerative disorders, infectious diseases, or tumors.
French National Center for Scientific Research and Aix - Marseille University | Date: 2015-04-09
A device for quantifying a useful thermal energy available in a tank for storing a heated or cooled fluid or solid includes: a plurality of thermoelectric converters configured to be distributed in plural locations of the storage tank; an electric circuit interconnecting the thermoelectric converters; a device measuring a single electrical variable of the electric circuit; and a converter converting a single measurement of the single electrical variable into a value for quantification of the useful thermal energy available in the storage tank.
French Institute of Health, Medical Research, Aix - Marseille University and Gfrs Groupe Francophone Of Recherche Sur La Sclerodermie Systemique | Date: 2015-03-12
The present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1. More, the invention relates to kits and array useful for carrying out diagnosis methods according to the present invention.
Aix - Marseille University and French National Center for Scientific Research | Date: 2015-05-11
The present invention relates to a method for displaying a graphical interface having display areas including a reference area, wherein each file of a file set is displayed in the form of an icon in one of the display areas, and each file of the file set contains a unique identifier identifying the file, and processing a command for inserting into the file set a selected pre-existing file which does not belong to the file set, the processing of the insertion command including the steps of: generating a new file in the file set, from the content of the selected pre-existing file, generating a unique identifier identifying the new file, and inserting into the new file the generated unique identifier and a reference link generated from a file identifier corresponding to each icon located in the reference area.
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-01-11
The present invention relates to a compound of formula (I) or (II) and its use for detecting and/or quantifying a solvent S_(1) in a solvent S_(2), S_(1) and S_(2) being distinct:_(1), R_(2), R_(3), R_(4), R_(5), R_(6), X, Y and n are as defined in claim 1.
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-04-19
The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
Mondal S.,Aix - Marseille University
Chemical Reviews | Year: 2012
A study was conducted to demonstrate the latest developments in the synthesis and application of sultones. It was demonstrated that several researchers were investigating sultone chemistry, as sultones were synthetically useful heterocycles in organic synthesis. Many powerful methodologies were developed for the synthesis of the sultones, such as intramolecular Diels-Alder reactions, ring-closing metathesis, Pd-catalyzed intramolecular coupling reactions, Rh-catalyzed C-H insertion, and Rh-catalyzed carbene cyclization cycloaddition cascade reactions. The syntheses of sultones have been divided into two categories for better understanding, such as asymmetric synthesis and nonasymmetric synthesis. Asymmetric syntheses of sultones became an attractive goal for the researchers, as chiral sultones offered novel possibilities for stereoselective transformations.
Pellissier H.,Aix - Marseille University
Advanced Synthesis and Catalysis | Year: 2012
Since about the year 2000, the research area of asymmetric organocatalysis has grown rapidly to become one of the most fascinating and current fields in organic chemistry. In the last years, asymmetric domino reactions have widely benefited from this fast-growing field, as exemplified by the development of an explosive number of novel and powerful asymmetric organocatalytic domino processes, which allowed the easy construction of complex chiral molecular architectures from simple materials with high yields and very often remarkable enantioselectivities in a metal-free environment. Indeed, the possibility to join two or more organocatalytic reactions in one asymmetric domino process has become a challenging goal for chemists, due to several advantages from economical and environmental points of view, avoiding costly protecting groups and time-consuming purification procedures after each step, for example. This review aims to update the latest developments of this hot and fascinating field, covering the literature since the beginning of 2009. Abbreviations: Ac: acetyl; Ar: aryl; BDHP: 1,1′-binaphth-2,2′-diyl hydrogen phosphate; BA: Brønsted acid; BINAPO: 2-diphenylphosphino-2′-diphenylphosphinyl-1, 1′-binaphthalene; BINOL: 1,1′-bi-2-naphthol; Boc: tert-butoxycarbonyl; Bn: benzyl; Bu: butyl; Bz: benzoyl; CSA: camphorsulfonic acid; Cy: cyclohexyl; Cbz: benzyloxycarbonyl; DABCO: 1,4-diazabicyclo[2.2.2] octane; DBU: 1,8-diazabicyclo[5.4.0]undec-7-ene; DCE: dichloroethane; de: diastereomeric excess; DFT: density functional theory; DHQ: hydroquinine; DHQD: dihydroquinidine; DIPEA: diisopropylethylamine; DKR: dynamic kinetic resolution; DMAD: dimethyl acetylenedicarboxylate; E: electrophile; ee: enantiomeric excess; ESI: electrospray ionization; Et: ethyl; Fu: furyl; Hept: heptyl; Hex: hexyl; HOMO: highest occupied molecular orbital; IBX: o-iodoxybenzoic acid; LB: Lewis base; LUMO: lowest unoccupied molecular orbital; Me: methyl; MOM: methoxymethyl; Mes: mesyl; MS: mass spectroscopy; MTBE: methyl tert-butyl ether; NADH: nicotinamide adenine dinucleotide; Naph: naphthyl; NHC: N-heterocyclic carbene; NMM: N-methylmorpholine; NMP: N-methylpyrrolidinone; Ns: nosyl; Nu: nucleophile; Oct: octyl; PCC: pyridinium chlorochromate; Pent: pentyl; PFBA: pentafluorobenzoic acid; Ph: phenyl; PMB: para-methoxybenzyl; Pr: propyl; Py: pyridine; r.t.: room temperature; TBA: tribromoacetic acid; TBS: tert-butyldimethylsilyl; TCBA: 2,4,6-trichlorobenzoic acid; TES: triethylsilyl; TFA: trifluoroacetic acid; THF: tetrahydrofuran; Thio: thiophene; TMEDA: tetramethylethylenediamine; TMS: trimethylsilyl; Tol: tolyl; Ts: 4-toluenesulfonyl (tosyl). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Ben-Ari Y.,Aix - Marseille University
Nature Reviews Neuroscience | Year: 2015
Birth is associated with a neuroprotective, oxytocin-mediated abrupt excitatory-to-inhibitory GABA shift that is abolished in autism, and its restoration attenuates the disorder in offspring. In this Opinion article, I discuss the links between birth-related stressful mechanisms, persistent excitatory GABA actions, perturbed network oscillations and autism. I propose that birth (parturition) is a critical period that confirms, attenuates or aggravates the deleterious effects of intrauterine genetic or environmental insults. © 2015 Macmillan Publishers Limited. All rights reserved.
Pellissier H.,Aix - Marseille University
Chemical Reviews | Year: 2013
Domino reactions are classified according to the mechanism of the individual steps, which may be of the same or different type. The quality and importance of a domino reaction can be correlated to the number of bonds generated in such a process and the increase in complexity. The concept of domino sequences has allowed easily reaching high molecular complexity with very often excellent levels of stereocontrol with simple operational procedures, as well as advantages of savings in solvent, time, energy, and costs. The use of one-component, two-component, and multicomponent domino reactions in asymmetric synthesis is increasing constantly. Such single-step reactions allow the synthesis of a wide range of structurally diverse and complex chiral molecules from simple substrates in an economically favorable manner by avoiding the use of costly and time-consuming protection deprotection processes, as well as purification procedures of intermediates.