Aix-Marseille University is a public research university located in Provence, southern France. With roots dating back to 1409, the university was formed by the merger of the University of Provence, the University of the Mediterranean and Paul Cézanne University. The merger became effective on 1 January 2012, resulting in the creation of the largest university in France and the French-speaking world, with about 70,000 students. AMU has the largest financial endowment of any academic institution in the Francophone world, standing at €650 million.The university is organized around five main campuses situated in Aix-en-Provence and Marseille. Apart from its major campuses, AMU owns and operates facilities in Arles, Aubagne, Avignon, Digne-les-Bains, Gap, La Ciotat, Lambesc and Salon-de-Provence. The university is headquartered at the Pharo, Marseille.AMU has produced many notable alumni in the fields of law, politics, business, economics and literature. To date, there have been four Nobel Laureates amongst its alumni and faculty, as well as a two-time recipient of the Pulitzer Prize, three César Award winners, several heads of state, parliamentary speakers, government ministers, ambassadors and members of the Institut de France.AMU has hundreds of research and teaching partnerships, including close collaboration with the French National Centre for Scientific Research and the French Atomic Energy and Alternative Energies Commission . AMU is a member of numerous academic organisations including the European University Association and the Mediterranean Universities Union . Wikipedia.
Aix - Marseille University | Date: 2015-03-10
The invention relates to a chimeric peptide displaying the ganglioside-binding properties of both -synuclein and -amyloid peptide. Such peptide is useful in preventing or treating any condition which involves gangliosides as cell surface receptor sites, including neurodegenerative disorders, infectious diseases, or tumors.
French National Center for Scientific Research and Aix - Marseille University | Date: 2015-04-09
A device for quantifying a useful thermal energy available in a tank for storing a heated or cooled fluid or solid includes: a plurality of thermoelectric converters configured to be distributed in plural locations of the storage tank; an electric circuit interconnecting the thermoelectric converters; a device measuring a single electrical variable of the electric circuit; and a converter converting a single measurement of the single electrical variable into a value for quantification of the useful thermal energy available in the storage tank.
French Institute of Health, Medical Research, Aix - Marseille University and Gfrs Groupe Francophone Of Recherche Sur La Sclerodermie Systemique | Date: 2015-03-12
The present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1. More, the invention relates to kits and array useful for carrying out diagnosis methods according to the present invention.
Aix - Marseille University and French National Center for Scientific Research | Date: 2015-05-11
The present invention relates to a method for displaying a graphical interface having display areas including a reference area, wherein each file of a file set is displayed in the form of an icon in one of the display areas, and each file of the file set contains a unique identifier identifying the file, and processing a command for inserting into the file set a selected pre-existing file which does not belong to the file set, the processing of the insertion command including the steps of: generating a new file in the file set, from the content of the selected pre-existing file, generating a unique identifier identifying the new file, and inserting into the new file the generated unique identifier and a reference link generated from a file identifier corresponding to each icon located in the reference area.
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-01-11
The present invention relates to a compound of formula (I) or (II) and its use for detecting and/or quantifying a solvent S_(1) in a solvent S_(2), S_(1) and S_(2) being distinct:_(1), R_(2), R_(3), R_(4), R_(5), R_(6), X, Y and n are as defined in claim 1.
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-04-19
The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
French Institute of Health, Medical Research and Aix - Marseille University | Date: 2015-12-15
The present invention relates to the general field of treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the treatment of immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.
Aix - Marseille University and French National Center for Scientific Research | Date: 2015-06-25
A device for extraction of pollutants by multichannel tubular membrane containing at least one fluid channel allowing the fluid to go through a feed inlet to an outlet end characterized in that membrane comprises at least an extraction channel filled with molten salt in order to adsorb said pollutants having to be extracted from the said fluid. Advantageously, the membrane is a ceramic membrane. An application is for the treatment of traces of pollutants in a liquid or gaseous fluid. For example, the removal of small pollutants as volatile organic compounds from an aqueous stream in industrial wastewater treatment or other water treatment applications, or the separation of aromatic compounds form an hydrocarbon feed in petrochemical applications. Another application is in the removal of water traces in products of high added value as pharmaceutical, cosmetic or biocarburant for example.
Aix - Marseille University and Assistance Publique Hopitaux De Marseille | Date: 2017-02-01
The present invention relates to antigen binding formats for use in therapeutic treatments or diagnostic assays. The present invention relates to an antigen-binding format consisting of:a first fusion protein wherein the CH1 constant domain of an antibody is fused i) by its N-terminal end to the C-terminal end of a variable domain of an antibody and ii) by its C-terminal end to the N-terminal end of a variable domain of an antibody and,a second fusion protein wherein the CL constant domain of an antibody is fused by its N-terminal end to the C-terminal end of a variable domain of an antibody.
Pellissier H.,Aix - Marseille University
Chemical Reviews | Year: 2013
Domino reactions are classified according to the mechanism of the individual steps, which may be of the same or different type. The quality and importance of a domino reaction can be correlated to the number of bonds generated in such a process and the increase in complexity. The concept of domino sequences has allowed easily reaching high molecular complexity with very often excellent levels of stereocontrol with simple operational procedures, as well as advantages of savings in solvent, time, energy, and costs. The use of one-component, two-component, and multicomponent domino reactions in asymmetric synthesis is increasing constantly. Such single-step reactions allow the synthesis of a wide range of structurally diverse and complex chiral molecules from simple substrates in an economically favorable manner by avoiding the use of costly and time-consuming protection deprotection processes, as well as purification procedures of intermediates.