Schwerin, Germany
Schwerin, Germany

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Fischer M.,University of Rostock | Fischer M.,Helmholtz Center Munich | Wohlfahrt S.,University of Rostock | Wohlfahrt S.,Helmholtz Center Munich | And 8 more authors.
Analytical Chemistry | Year: 2015

This work describes an ultrafast-cycling gas chromatography module (fast-GC module) for direct-sampling gas chromatography/mass spectrometry (GC-MS). The sample can be introduced into the fast-GC module using a common GC injector or any GC x GC modulator. The new fast-GC module offers the possibility to conduct a complete temperature cycle within 30 s. Its thermal mass is minimized by using a specially developed home-built fused silica capillary column stack and a halogen lamp for heat generation, both placed inside a gold-coated quartz glass cylinder. A high airflow blower enables rapid cooling. The new device is highly flexible concerning the used separation column, the applied temperature program, and the integration into existing systems. An application of the fast-GC module is shown in this work by thermal analysis coupled to gas chromatography-mass spectrometry (TA-GC-MS). The continuously evolving gases of the TA are modulated by a liquid CO2 modulator. Because of the rapid cycling of the fast-GC module, it is possible to obtain the best separation while maintaining the online character of the TA. Restrictions in separation and retention time shifting, known from isothermal and normal ramped fast-GC systems, are overcome. (Graph Presented). © 2015 American Chemical Society.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: DRS-02-2014 | Award Amount: 12.91M | Year: 2015

The seven specific objectives of TOXI-triage address the operational; technological; ethical and societal dimensions of CBRN response and recovery, and importantly the economic base from which sustainable CBRN and multi-use systems are derived. 19 partners in 4 Task forces will deliver 9 Work Packages (WPs) that address: end user specifications; Design and delivery; Test and Validation; and, Impact. The approach defines a concept of operations that envisages accelerated delivery of situational awareness through an ensemble of embedded sensors, drones, standoff detectors (including cameras), artificial intelligence for processing sensor signals and web-traffic from social media, and centralised command and control. Wireless traceability of casualties provides dynamic mapping including medical care. 2 field exercises are intended to test and verify the operational attributes of the systems, and 3 WPs focus on impact to deliver: Exploitation; Security and Ethics; and Effective Innovation Management. Distinctive technological attributes of TOXI-triage include: rapid non-invasive assessment of exposure/ injury through monitoring metabolic markers of injury; managing and exploiting the semantic web; traceability by design; aptamer-based bio-sensing; casualty-to-discharge system integration; and integrated environmental and stand-off hazard designation. The approach is rigorous with clinical trials to test systems in poisoning clinics and live agent tests in laboratories designated by the UNs OPCW. Distinctive societal attributes of TOXI-triage include: addressing the needs of all vulnerable groups; optimising inter-cultural/ethnic messages and needs in CBRN response; fostering economic impact by multiple-uses for all the projects systems. TOXI-triage intends that its outcomes will be used routinely in medical/environmental/urban and search and rescue emergencies. The benefits are intended to extend significantly further then enhanced CBRN resilience


Ehlert S.,University of Rostock | Walte A.,Airsense Analytics GmbH | Zimmermann R.,University of Rostock | Zimmermann R.,Helmholtz Center for Environmental Research
Analytical Chemistry | Year: 2013

The development of fast, mobile, and sensitive detection systems for security-relevant substances is of enormous importance. Because of the low vapor pressures of explosives and improvised explosive devices, adequate sampling procedures are crucial. Ion mobility spectrometers (IMSs) are fast and sensitive instruments that are used as detection systems for explosives. Ambient pressure laser desorption (APLD) and ambient pressure laser-induced acoustic desorption (AP-LIAD) are new tools suitable to evaporate explosives in order to detect them in the vapor phase. Indeed, the most important advantage of APLD or AP-LIAD is the capability to sample directly from the surface of interest without any transfer of the analyte to other surfaces such as wipe pads. A much more gentle desorption, compared to classical thermal-based desorption, is possible with laser-based desorption using very short laser pulses. With this approach the analyte molecules are evaporated in a very fast process, comparable to a shock wave. The thermal intake is reduced considerably. The functionality of APLD and AP-LIAD techniques combined with a hand-held IMS system is shown for a wide range of common explosives such as EGDN (ethylene glycol dinitrate), urea nitrate, PETN (pentaerythritol tetranitrate), HMTD (hexamethylene triperoxide diamine), RDX (hexogen), tetryl (2,4,6-trinitrophenylmethylnitramine), and TNT (trinitrotoluene). Detection limits down to the low nanogram range are obtained. The successful combination of IMS detection and APLD/AP-LIAD sampling is shown. © 2013 American Chemical Society.


PubMed | Photonion GmbH, Helmholtz Center Munich, University of Rostock, Airsense Analytics GmbH and Netzsch Geraetebau GmbH
Type: Journal Article | Journal: Analytical chemistry | Year: 2015

This work describes an ultrafast-cycling gas chromatography module (fast-GC module) for direct-sampling gas chromatography/mass spectrometry (GC-MS). The sample can be introduced into the fast-GC module using a common GC injector or any GC GC modulator. The new fast-GC module offers the possibility to conduct a complete temperature cycle within 30 s. Its thermal mass is minimized by using a specially developed home-built fused silica capillary column stack and a halogen lamp for heat generation, both placed inside a gold-coated quartz glass cylinder. A high airflow blower enables rapid cooling. The new device is highly flexible concerning the used separation column, the applied temperature program, and the integration into existing systems. An application of the fast-GC module is shown in this work by thermal analysis coupled to gas chromatography-mass spectrometry (TA-GC-MS). The continuously evolving gases of the TA are modulated by a liquid CO2 modulator. Because of the rapid cycling of the fast-GC module, it is possible to obtain the best separation while maintaining the online character of the TA. Restrictions in separation and retention time shifting, known from isothermal and normal ramped fast-GC systems, are overcome.


Allers M.,Leibniz University of Hanover | Bohnhorst A.,Leibniz University of Hanover | Kirk A.T.,Leibniz University of Hanover | Ungethum B.,Airsense Analytics GmbH | And 2 more authors.
International Journal for Ion Mobility Spectrometry | Year: 2015

Ion mobility spectrometers can be divided by their principle of ion separation. For example, classical drift tube time-of-flight Ion Mobility Spectrometers (IMS) separate ions by the absolute value of their low field ion mobility; Field Asymmetric Ion Mobility Spectrometers (FAIMS) separate ions by the field dependence of their ion mobility. However, the low field mobilities and the field dependence of the mobility vary only within a limited range for different ions, leading to a limited peak capacity of stand-alone drift tube IMS and FAIMS. Combining both types leads to orthogonal data and thus enhances the selectivity in comparison with stand-alone devices. In this work, a new approach of enhancing the separation power of a classical drift tube IMS by integrating a field asymmetric waveform ion separation region in longitudinal direction into the drift tube is discussed. This additional separation region is realized by superimposing the constant drift field of a drift tube IMS with an asymmetric parallel AC field using two additional grids inside the drift tube. Since the ions are exposed alternately to high field and low field strengths on their way through the additional separation region, the resulting drift time is affected. Hence, two ion species having the same low-field mobility, but showing a different field dependence of the mobility have different drift times in the enhanced IMS. In order to analyze the ion movement inside such a modified ion mobility spectrometer, the finite element method (FEM) software Comsol Multiphysics is used. Therefore, an existing drift tube IMS model which perfectly agrees with experimental results and considers field inhomogenieties, diffusion, Coulomb repulsion and ion losses at metallic surfaces, is expanded in order to simulate the ion movement in AC fields. This enhanced model provides visualization of the location and shape of the ion cloud during DC/AC operation. Particular attention is given to the increased broadening of the ion cloud due to field inhomogenieties in the additional AC field. Furthermore, ion losses inside the drift tube caused by the AC field and the additional grids are considered. In this work, simulations are used to theoretically investigate our new separation approach to give a first impression of the possible analytical performance. © 2015, Springer-Verlag Berlin Heidelberg.


Patent
Airsense Analytics GmbH | Date: 2011-05-13

The invention relates to a device (10) for detection of harmful substances with a measurement unit (28) for measuring at least one harmful substance and an evaluation unit (30) for determining the concentration of the at least one harmful substance. The invention also relates to a method for detecting harmful substances in a gas mixture. It is hereby provided that the gas mixture is tested for a gaseous harmful substance or simultaneously for several gaseous harmful substances, wherein the gaseous harmful substance or the gaseous harmful substances is/are measured with different sensor means, and the gaseous harmful substances are optionally chemically modified such that a measurement is performed with the existing sensor means.


The invention relates to identifying not easily volatilized substances, in particular hazardous material, in a gas phase. A measurement cell and gas supply installations connected to the measurement cell are heated, and a plasmonic surface arranged in the measurement cell is temperature-controlled such that the plasmonic surface has a lower temperature than the measurement cell and the gas supply installations. The gas phase is guided through the gas supply installations into the measurement cell such that the gas phase reaches the plasmonic surface. Substances adsorbed out of the gas phase on the plasmonic surface are analyzed by an optical process. Surface-enhanced Raman spectroscopy or surface-enhanced infrared spectroscopy may be used. Selectivity can be increased by combining both methods. Selectivity can be additionally increased by using a gas detector, preferably an ion-mobility spectrometer. Thus the false alarm rate is reduced without a loss of time.


The invention relates to a method for identifying gases, which are ionized and the drift times of the positive and negative product ions through drift spaces are measured and the measured drift times are evaluated, wherein for measuring the drift times the product ions are accelerated to drift velocities by a resulting electrical field. It is provided that the positive and negative product ions move synchronously and in parallel in the same direction. The invention further relates to a device for identifying gases, which includes at least two drift tubes, wherein each of the drift tubes has at least one respective detector for detecting product ions. For this purpose, at least two drift tubes are arranged in parallel next to each other and are delimited, on one hand, by a common inlet system and, on the other hand, by at least one detector.


Patent
Airsense Analytics GmbH | Date: 2016-06-17

Method and device for identifying gases and/or ion mobility spectrometer and method for offsetting residual humidity are provided. The object of the invention is to develop a generic method for offsetting residual humidity in an ion mobility spectrometer and a related device, which has a simple structure and which fully exploits the reduced diffusion. This is achieved by a variable drift chamber drift gas velocity, which leads to differing penetration depths of the humidity into the drift chamber, and thus to variable residual humidities in the drift chamber. Methods of this type and the associated devices for detecting and identifying gases are used to recognise and identify chemical compounds, in particular explosive materials or material compounds and/or those which are damaging to health, and which must be identified in very low concentrations.


The invention relates to a method for ionizing and identifying gases, wherein the gases to be identified are ionized in a reaction chamber and the product ions are measured, wherein the measurement of the product ions takes place via electrical fields acting on the product ions and the detection is performed with a detector for ions. It is provided that ionization takes place via UV radiation, and that simultaneously or sequentially ionization by electrons takes place. The invention further relates to a device for ionizing and identifying gases, which includes an ion source chamber having an ion source and an ion mobility spectrometer. For this purpose, a partition between the ion source chamber and the ion mobility spectrometer has a UV-transparent window and a window permeable for electrons, wherein UV radiation and electron radiation can be generated in the ion source chamber with the ion source.

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