General Air Force Hospital

Beijing, China

General Air Force Hospital

Beijing, China
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Zini G.,National and Kapodistrian University of Athens | Bain B.,St Marys Hospital | Bettelheim P.,Otto Wagner Hospital | Cortez J.,Portuguese Oncology Institute | And 15 more authors.
British Journal of Haematology | Year: 2010

This paper describes the methodology used to develop a consensual glossary for haematopoietic cells within Diagnostics-WP10 of European-LeukemiaNet EU-project. This highly interactive work was made possible through the use of the net, requiring only a single two-day meeting of actual confrontation and debate. It resulted in the production of a freely accessible tool that could be useful for training as well as harmonization of morphological reports in onco-haematology especially, without geographic limitation, not limited to European countries. Moreover, this collective work resulted in the production of a consensus statement, taking into account individual practices, collegial agreement and literature data. © 2010 Blackwell Publishing Ltd.


Lampropoulos K.M.,General Air force Hospital | Lampropoulos K.M.,National and Kapodistrian University of Athens | Dounis V.G.,General Air force Hospital | Aggeli C.,National and Kapodistrian University of Athens | And 2 more authors.
Hellenic Journal of Cardiology | Year: 2011

Left ventricular non-compaction (LVNC) is a cardiomyopathy considered to be caused by arrest of normal embryogenesis of the endocardium and myocardium. Echocardiography has been the preferred diagnosticprocedure; however, the correct diagnosis is often missed or delayed due to the lack of knowledge about this uncommon disease and its similarities to other diseases of the myocardium and endocardium. Here we present two cases: an asymptomatic 39-year-old man who was considered to be suffering from dilated cardiomyopathy(DCM) for four years; and an asymptomatic 19-year-old man who was considered to be sufferingfrom hypertrophic cardiomyopathy. In a recent echocardiography study carried out in our echo lab,we recognized the morphological diagnostic criteria of LVNC. Contrast echocardiography, a low-cost, easy,repeatable, real-time, and non-invasive technique with no ionising radiation, shows a high correlation in the diagnosis of LVNC. In echocardiography, the importance of contrast agents is twofold, as they can be considered essential for a reliable differentiation between the compacted and the non-compacted myocardium,while at the same time they allow accurate measurement of the ratio. Heightened clinical suspicion is necessary for the accurate diagnosis and management of diseases.


Bozas G.,National and Kapodistrian University of Athens | Terpos E.,General Air Force Hospital | Gika D.,National and Kapodistrian University of Athens | Karadimou A.,National and Kapodistrian University of Athens | And 2 more authors.
International Journal of Gynecological Cancer | Year: 2010

Background: Serum CD105 has been associated with angiogenic activity in cancer, and low CD105 expression has been associated with improved prognosis. The present study evaluated the prognostic significance of serum levels of CD105 and related factors in patients with epithelial ovarian cancer (EOC) after cytoreductive surgery and chemotherapy. Patients and Methods: Eighty-six patients with stages IIC to IV EOC treated postoperatively with platinum-based chemotherapy were included. The enzyme-linked immunosorbent assay was used to measure prechemotherapy serum levels of CD105, transforming growth factor β1/2 (TGF-β1/2), angiopoietin 2, vascular endothelial growth factor, and tumor necrosis factor-α. Results: High levels of TGF-β2 (≥8908.86 pg/mL) and CD105 (≥4.25 ng/mL) were independently associated with improved overall survival (not reached vs 39 months, P = 0.009 and 75 vs 39 months, P = 0.029, respectively), whereas a high level of TGF-β2 and a low level of vascular endothelial growth factor (<219.04 pg/mL) were independently associated with improved progression-free survival (49 vs 17 months, P = 0.022 and 57 vs 16 months, P = 0.023, respectively). Among patients with favorable (≥4.25 ng/mL) CD105 levels, only patients with low TGF-β1 levels (<177.1 ng/mL) had superior survival than patients with low CD105 levels. Conclusions: Our study confirms the prognostic significance of angiogenesis in EOC and supports a biological interaction between CD105 and TGF-β1. High angiogenic activity may be associated by increased efficacy of postoperative chemotherapy. Copyright© 2010 by IGCS and ESGO.


Wu L.,Chinese PLA General Hospital | Herman J.G.,Johns Hopkins University | Brock M.V.,Johns Hopkins University | Wu K.,Huazhong University of Science and Technology | And 7 more authors.
PLoS ONE | Year: 2014

Human Dachshund homologue 1 (DACH1) is a major component of the Retinal Determination Gene Network. Loss of DACH1 expression was found in breast, prostate, lung, endometrial, colorectal and hepatocellular carcinoma. To explore the expression, regulation and function of DACH1 in human esophageal cancer, 11 esophageal cancer cell lines, 10 cases of normal esophageal mucosa, 51 cases of different grades of dysplasia and 104 cases of primary esophageal squamous cancer were employed. Methylation specific PCR, immunohistochemistry, western blot, flow cytometry, small interfering RNAs, colony formation techniques and xenograft mice model were used. We found that DACH1 expression was regulated by promoter region hypermethylation in esophageal cancer cell lines. 18.8% (6 of 32) of grade 1, 42.1% (8 of 19) of grade 2 and grade 3 dysplasia (ED2,3), and 61.5% (64 of 104) of esophageal cancer were methylated, but no methylation was found in 10 cases of normal esophageal mucosa. The methylation was increased in progression tendency during esophageal carcinogenesis (P,0.01). DACH1 methylation was associated with poor differentiation (P,0.05) and late tumor stage (P, 0.05). Restoration of DACH1 expression inhibited cell growth and activated TGF-b signaling in KYSE150 and KYSE510 cells. DACH1 suppressed human esophageal cancer cell tumor growth in xenograft mice. In conclusion, DACH1 is frequently methylated in human esophageal cancer and methylation of DACH1 is involved in the early stage of esophageal carcinogenesis. DACH1 expression is regulated by promoter region hypermethylation. DACH1 suppresses esophageal cancer growth by activating TGF-b signaling. Copyright: © 2014 Reekie et al.


Lampropoulos K.M.,General Air Force Hospital | Lampropoulos K.M.,University Hospitals Leuven | Iliopoulos T.A.,General Air Force Hospital | Budts W.,University Hospitals Leuven
Journal of Medical Case Reports | Year: 2011

Introduction. Although stents have improved the safety and efficacy of percutaneous coronary interventions, coronary stent thrombosis remains a serious complication. Case presentation. We present the case of a 64-year-old Caucasian man from Greece, with symptoms and electrocardiographic findings suggestive of acute inferior myocardial infarction, who complained of chest pain and rapidly developed cardiogenic shock 48 hours after primary percutaneous coronary intervention. Conclusion: The most common cause of early bare-metal stent thrombosis is stent malapposition. Intravascular ultrasound is the preferred method to recognize predictors of coronary events that are not detected by angiography. © 2011 Lampropoulos et al; licensee BioMed Central Ltd.


Lampropoulos K.M.,General Air Force Hospital | Lampropoulos K.M.,Surgery Academy | Marinakis A.,General Air Force Hospital | Sokolis D.P.,Surgery Academy | Iliopoulos T.A.,General Air Force Hospital
Journal of Clinical Hypertension | Year: 2010

The aim of this research was to describe N-terminal part of the prohormone B-type natriuretic peptide (NT-proBNP) levels over time in patients with acute coronary syndrome (ACS) before and after percutaneous coronary intervention (PCI). NT-proBNP, troponin I (Tn-I), creatine kinase (CK), CK MB isoenzyme (CKMB), fibrinogen, D-dimers, and C-reactive protein (CRP) were measured in 300 consecutive patients with ACS before undergoing successful reperfusion with PCI in the first 48 hours, 2 days after, and at the end of the 1st, 3rd, 6th, 12th, 18th, and 24th month. The concentration of NT-proBNP was cross-correlated with the levels of NT-proBNP in 300 patients without ACS and was significantly increased before and after PCI and at the end of the 3rd month, contrasting with the fast conversion to normal levels of Tn-I, CK, CKMB, fibrinogen, D-dimers, and CRP. In patients with ACS undergoing successful PCI, NT-proBNP shows slow kinetics, especially in patients with an increased thrombolysis in myocardial infarction risk score, hypertension, and diabetes. Nevertheless, cardiac neurohormonal activation may be a unifying feature among patients at high risk for cardiovascular events after ACS and PCI. © 2010 Wiley Periodicals, Inc.


Zhu M.,General Air Force Hospital | Zhang J.,General Air Force Hospital | Tang J.,General Air Force Hospital | Mao G.-P.,General Air Force Hospital | And 3 more authors.
World Chinese Journal of Digestology | Year: 2014

Aim: To investigate the diagnostic value of single balloon endoscopy (SBE) in obscure gastrointestinal bleeding (OGIB). Methods: Clinical data for 115 patients with OGIB who underwent SBE from July 2009 to May 2013 were retrospectively analyzed. The causes of gastrointestinal bleeding were observed by SBE. Eleven patients underwent endoscopic therapy. Results: The detection rate of gastrointestinal bleeding was 73.91% (85/115). The most common reasons for OGIB were small intestinal ulcer, small intestinal diverticulum, mucosal inflammatory changes, interstitialoma, small intestine carcinoma, Crohn's disease, small intestinal polyps, vascular dilatation, and other rare diseases. Seventy-eight (67.83%) patients had overt bleeding, and 37 (32.17%) had occult bleeding. The detection rate of overt bleeding was significantly higher than that of occult bleeding (P < 0.05). Conclusion: SBE has high diagnostic yield in OGIB, and is a safe and reliable method for diagnosis and treatment of OGIB. The most common reasons for OGIB are small intestinal ulcer, small intestinal diverticulum, and mucosal inflammatory changes. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.


PubMed | General Air Force Hospital
Type: Clinical Trial | Journal: Journal of clinical hypertension (Greenwich, Conn.) | Year: 2010

The aim of this research was to describe N-terminal part of the prohormone B-type natriuretic peptide (NT-proBNP) levels over time in patients with acute coronary syndrome (ACS) before and after percutaneous coronary intervention (PCI). NT-proBNP, troponin I (Tn-I), creatine kinase (CK), CK MB isoenzyme (CKMB), fibrinogen, D-dimers, and C-reactive protein (CRP) were measured in 300 consecutive patients with ACS before undergoing successful reperfusion with PCI in the first 48 hours, 2 days after, and at the end of the 1st, 3rd, 6th, 12th, 18th, and 24th month. The concentration of NT-proBNP was cross-correlated with the levels of NT-proBNP in 300 patients without ACS and was significantly increased before and after PCI and at the end of the 3rd month, contrasting with the fast conversion to normal levels of Tn-I, CK, CKMB, fibrinogen, D-dimers, and CRP. In patients with ACS undergoing successful PCI, NT-proBNP shows slow kinetics, especially in patients with an increased thrombolysis in myocardial infarction risk score, hypertension, and diabetes. Nevertheless, cardiac neurohormonal activation may be a unifying feature among patients at high risk for cardiovascular events after ACS and PCI.

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