Takatsuki, Japan
Takatsuki, Japan

Aino University is a private university in Takatsuki, Osaka, Japan, established in 2004. Wikipedia.

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Onishi M.,University of Tokyo | Kanda K.,Aino University
Journal of Interprofessional Care | Year: 2013

Studies of physician-nurse relationships have focused mainly on nurses' perceptions. Few studies have explored physicians' perceptions and related factors. This study had two aims: to describe physicians' perceptions of physician-nurse collaboration in Japan by focusing on attitudes toward collaboration and collaborative practice and to examine the effect of physicians' experiences related to collaboration on their perceptions of collaboration. A cross-sectional survey was conducted. Of the 520 physicians from four hospitals, 248 completed the survey. The survey included the Jefferson Scale of attitudes toward physician-nurse collaboration, the collaborative practice scales, learning experiences related to collaboration with nurses and experiences of joint activities with nurses. Multiple regression analysis revealed that learning experiences in undergraduate and out-of-hospital education and experiences of joint committee work were significantly associated with higher collaborative practice scores. Although participants' attitude scores had a strong association with practice scores, there were no variables significantly associated with the attitude score. This study supported the importance of education in undergraduate courses and suggested that it should be ongoing after qualification. Joint activities other than daily practice, such as continuous quality improvement, might also be effective. Factors that improve physicians' attitudes toward collaboration should be further explored. © 2013 Informa UK, Ltd.

Suzuki Y.,Kitano Hospital | Ishikawa N.,Kitano Hospital | Omae K.,Translational Research Informatics Center | Hirai T.,Kitano Hospital | And 6 more authors.
Restorative Neurology and Neuroscience | Year: 2014

Purpose: This study was conducted to assess the safety and feasibility of intrathecal transplantation of autologous bone marrow-derived mononuclear cells for the treatment of patients with spinal cord injury. Methods: Ten patients were included in the study. Approximately 120 ml of bone marrow aspirate was obtained from bilateral iliac bone of patients with spinal cord injury. Isolation of mononuclear cells was performed using Ficoll density-gradient centrifugation. Bone marrow mononuclear cells were transplanted into cerebrospinal fluid by lumbar puncture. Functional tests were performed prior to the cell transplantation and six months after cell transplantation. The patients were carefully observed for up to six months. Results: In 5 patients with AIS A prior to cell transplantation, 1 patient converted to AIS B six months after cell transplantation. In 5 patients with AIS B, 1 patient converted to AIS D and 2 patients to AIS C. MRI did not show any complication. Two patients showed slight anemia after aspiration of bone-marrow cells, which returned to normal level within a several weeks. Conclusion: The results of this study suggest that this method may be safe and feasible. © 2014 - IOS Press and the authors. All rights reserved.

Saito F.,Kansai Medical University | Nakatani T.,Kansai Medical University | Iwase M.,Kansai Medical University | Maeda Y.,Kansai Medical University | And 4 more authors.
Restorative Neurology and Neuroscience | Year: 2012

Purpose: To determine whether intrathecal administration of cultured autologous bone marrow stromal cells (BMSCs) is safe and feasible for treatment of subacute spinal injury. Methods: Five patients with complete tetraplegia due to cervical spinal injury on admission were included. A small amount of bone marrow was obtained during surgery for spinal fusion. BMSCs were cultured, reaching 10 7-10 8 cells. The properties and functional efficacy of the BMSCs were verified with surface marker analysis and a neurite extension test. BMSCs were administered by lumbar puncture. The patients were closely observed for 6 months, and the Committee on Effectiveness and Safety of Clinical Treatment (CESCT) evaluated safety. Results: No adverse responses were observed in biochemical and radiographic examinations. The CESCT did not recognize any harmful effects of the transplantation, and concluded it was safe for treatment. The patients were further followed up for 1 to 4 years with no adverse responses. The recovery of American Spinal Injury Association Impairment Scale (AIS) B and C patients at transplantation was rapid and remarkable, but gradual or limited in AIS A patients. Conclusion: This study demonstrated that intrathecal administration of cultured autologous BMSCs is safe and feasible for treatment of spinal cord injury. © 2012 - IOS Press and the authors. All rights reserved.

Wiens M.,Johannes Gutenberg University Mainz | Wiens M.,NanotecMARIN GmbH | Wang X.,Johannes Gutenberg University Mainz | Wang X.,National Research Center for Geoanalysis | And 6 more authors.
Biomaterials | Year: 2010

Earlier studies have demonstrated that biosilica, synthesized by the enzyme silicatein, induces hydroxyapatite formation in osteoblast-like SaOS-2 cells. Here we study the effect of biosilica on the expressions of osteoprotegerin [. OPG] and the receptor activator for NF-κB ligand [. RANKL] in the SaOS-2 cell model. We show that during growth of SaOS-2 cells on biosiliceous matrices hydroxyapatite formation is induced, while syntheses of cartilaginous proteoglycans and sulfated glycosaminoglycans are down-regulated. Furthermore, quantitative real-time RT-PCR analysis revealed a strong time-depended increase in expression of OPG in biosilica exposed SaOS-2 cells while the steady-state expression level of RANKL remained unchanged. These results have been corroborated on the protein level by ELISA assays. Therefore, we propose that biosilica stimulated OPG synthesis in osteoblast-like cells counteracts those pathways that control RANKL expression and function (e.g. maturation of pre-osteoclasts and activation of osteoclasts). Hence, the data obtained in the present study reveal the considerable biomedical potential of biosilica for treatment and prophylaxis of osteoporotic disorders. © 2010 Elsevier Ltd.

Hashimoto H.,Aino University | Hashimoto H.,Osaka Prefecture University | Takabatake S.,Osaka Prefecture University | Miyaguchi H.,Hiroshima University | And 2 more authors.
Complementary Therapies in Medicine | Year: 2015

Objective: To examine the effectiveness of dance on motor functions, cognitive functions, and mental symptoms of Parkinson's disease (PD). Design: This study employed a quasi-randomised, between-group design. Setting: Dance, PD exercise, and all assessments were performed in community halls in different regions of Japan. Participants: Forty-six mild-moderate PD patients participated. Intervention: Six PD patient associations that agreed to participate in the study were randomly assigned to a dance group, PD exercise group, or non-intervention group. The dance and PD exercise groups performed one 60-min session per week for 12 weeks. Control group patients continued with their normal lives. All groups were assessed before and after the intervention. Main outcome measures: We used the Timed Up-and-Go Test (TUG) and Berg Balance Scale (BBS) to assess motor function, the Frontal Assessment Battery at bedside (FAB) and Mental Rotation Task (MRT) to assess cognitive function, and the Apathy Scale (AS) and Self-rating Depression Scale (SDS) to assess mental symptoms of PD. The Unified Parkinson's Disease Rating Scale (UPDRS) was used for general assessment of PD. Results: When comparing results before and after intervention, the dance group showed a large effect in TUG time (ES. = 0.65, p= 0.006), TUG step number (ES = 0.66, p= 0.005), BBS (ES = 0.75, p= 0.001), FAB (ES = 0.77, p= 0.001), MRT response time (ES = 0.79, p< 0.001), AS (ES = 0.78, p< 0.001), SDS (ES = 0.66, p= 0.006) and UPDRS (ES = 0.88, p< 0.001). Conclusions: Dance was effective in improving motor function, cognitive function, and mental symptoms in PD patients. General symptoms in PD also improved. Dance is an effective method for rehabilitation in PD patients. © 2015 Elsevier Ltd.

Wang X.,Johannes Gutenberg University Mainz | Wang X.,Chinese Academy of Geological Sciences | Schroder H.C.,Johannes Gutenberg University Mainz | Wiens M.,Johannes Gutenberg University Mainz | And 2 more authors.
Current Opinion in Biotechnology | Year: 2012

Bio-silica represents the main mineral component of the sponge skeletal elements (siliceous spicules), while bio-polyphosphate (bio-polyP), a multifunctional polymer existing in microorganisms and animals acts, among others, as reinforcement for pores in cell membranes. These natural inorganic bio-polymers, which can be readily prepared, either by recombinant enzymes (bio-silica and bio-polyP) or chemically (polyP), are promising materials/substances for the amelioration and/or treatment of human bone diseases and dysfunctions. It has been demonstrated that bio-silica causes in vitro a differential effect on the expression of the genes OPG and RANKL, encoding two mediators that control the tuned interaction of the anabolic (osteoblasts) and catabolic (osteoclasts) pathways in human bone cells. Since bio-silica and bio-polyP also induce the expression of the key mediator BMP2 which directs the differentiation of bone-forming progenitor cells to mature osteoblasts and in parallel inhibits the function of osteoclasts, they are promising candidates for treatment of osteoporosis. © 2012 Elsevier Ltd.

Okitsu S.,Aino University | Okitsu S.,Tokyo International University | Khamrin P.,Chiang Mai University | Thongprachum A.,Tokyo International University | And 4 more authors.
Journal of Clinical Microbiology | Year: 2011

Of 131 stool samples collected from piglets with diarrhea in northern Thailand between July 2006 and August 2008, 14 (10.7%) were positive for group A rotavirus. Sequence analysis showed that 13 strains (92.9%) belonged to the rare P[23] genotype combination with G9 or G3 genotypes. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

Pham N.T.K.,Tokyo Medical University | Trinh Q.D.,Tokyo Medical University | Khamrin P.,Aino University | Maneekarn N.,Chiang Mai University | And 4 more authors.
Journal of Clinical Microbiology | Year: 2010

A total of 82 fecal specimens which were known to be negative for rotavirus, adenovirus, norovirus, sapovirus, and astrovirus and which were collected from infants and children with acute gastroenteritis in Chiang Mai, Thailand, from January to December 2005 were screened for human parechovirus (HPeV). HPeV was detected by reverse transcription-PCR with a primer pair that amplified the 5′ untranslated region of its genome and was genotyped by sequencing of the VP1 region. HPeV was detected in 12 of 82 specimens tested, and the detection rate was found to be 14.6%. The capsid VP1 gene was successfully sequenced from nine of the HPeV strains detected. The HPeV strains studied clustered into four different genotypes, HPeV genotype 1 (HPeV1) to HPeV4, and the majority of the strains studied (five strains) belonged to HPeV1. This is the first finding of HPeV from children with acute gastroenteritis in Thailand. In addition, the diversity of the Thai HPeV strains was also noted. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Yoh K.,Aino University
Japanese Journal of Anesthesiology | Year: 2015

Rehabilitation medicine regards pain as one disorder of whole human character and handles pain through multilateral approaches. When only the pain is treated it will not be relieved easily. Chronic pain can be more effectively handled if pain is considered as one obstacle of the whole human character and handled using many skills of rehabilitation medicine. We should apply physiotherapy including functional treatment, physical treatment and exercise from early stages of acute pain and approach chronic pain. This could improve the effectiveness of treatment for many kinds of acute pain and chronic pain disorders.

Dey S.K.,Tokyo Medical University | Phathammavong O.,University of Tokyo | Okitsu S.,Aino Health Research Center | Mizuguchi M.,Tokyo Medical University | And 2 more authors.
Pediatric Infectious Disease Journal | Year: 2010

A total of 6231 fecal specimens collected from infants and children with gastroenteritis in 7 different regions of Japan during 1995 to 2007 were examined for norovirus. Norovirus was detected in 779 patients (12.5%) and norovirus activity peak in the winter season (November to January) during 1995 to 2007. During the last 11 years, NoVGII/4 was the predominant strain in Japan followed by GII/3, GII/6, GII/2, GII/12, and GI. © 2010 Lippincott Williams & Wilkins.

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