Karnataka, India
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Sasidharan P.,AIMS
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: To collect informational resources and Compilation of Drug information to formulate an Ideal Pediatric Drug Formulary. Formulary is a continually revised compilation of pharmaceuticals (plus important ancillary information) that reflect the current clinical judgment of the medical staff. Hospital formulary is a comprehensive list of every drug and therapeutic agent stocked by the pharmacy of that hospital. Methods: Prospective & developmental study.The study was carried out in Department of Pediatrics & Neonatology in Amrita Institute of Medical Sciences (AIMS) a 1200 bedded tertiary care referral hospital in Cochin. Results: The first edition of pediatric formulary & drug therapy guide was published in June 2013 and has been using in Pediatrics & Neonatology department Conclusion: The Pediatric formulary & drug therapy guide is of course first of its kind in the country. It proved to be a reliable guide in individualization of drug therapy and serves as a channel for enhancing clinical efficacy and reducing the untoward outcomes. The drug monographs included in this formulary is indeed a worthful reference resource with all the necessary informations for all pediatric practitioners.

Janardhana S.,AIMS | Jaya J.,Annamalai University | George J.,Annamalai University
2013 International Conference on Current Trends in Engineering and Technology, ICCTET 2013 | Year: 2013

The aim of this review paper is to emphasis Computer Aided Inspection (CAI) system for the detection of defects in food products. As the food products are being consumed directly (processed / Unprocessed) by human beings, defects in food products cause serious health hazards which insists to develop an inspection system which facilitates for food products of high quality and safety standards. CAI system provides an alternative for an automated, non-destructive and cost effective technique to accomplish accurate, fast and objective quality determination. This CAI system is based on image Analysis and processing which can be adopted in food industry. The various stages of CAI system consists of preprocessing, enhancement, segmentation, feature extraction and classification. Considerable research as proven its potential for inspection and grading of fruits, meat, vegetables, grain, bakery products, confessionary products and processed food products. This paper reviews the recent development and advances of CAI in the food industry. The fundamental elements of the system and technology are examined. © IEEE 2013.

Haridas N.,AIMS | Suraj K.P.,Institute of Chest Diseases | Rajagopal T.P.,Institute of Chest Diseases | James P.T.,Institute of Chest Diseases | Chetambath R.,Government Medical College
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Pleural effusion is a common diagnostic dilemma for the pulmonologist. A histological diagnosis would many a time steer the way to an accurate diagnosis of the aetiologies of pleural effusions. This study has compared two methods for obtaining histological specimens in cases of undiagnosed pleural effusions. Aim: To compare the efficacy of closed pleural biopsy with Abrahm's needle and medical thoracoscopic biopsy in the diagnosis of undiagnosed exudative pleural effusions at a tertiary care setting. Study Design: Randomized controlled study. Study Period: November 2008-October 2010. Methodology: All patients who were admitted with pleural effusions underwent a clinical workup for pleural effusions. Light's criterion was used to differentiate between exudative and transudative pleural effusions. Those patients with exudative pleural effusions, who did not have a specific diagnosis, were included in the study. Fifty eight patients were included in the study and they were randomized into 2 Groups of 29 patients each. One group was subjected to medical thoracoscopic pleural biopsy and the other to closed pleural biopsy with Abrahm's needle. Demographic, clinical and biochemical characteristics, diagnostic yields and the complications among the two groups were compared. Result: Medical thoracoscopy has a diagnostic yield of 86.2% with complication rate of 10.3% compared to 62.1% and 17.2% respectively in closed pleural biopsy group. Conclusion: Medical thoracoscopic pleural biopsy had a better diagnostic yield with a lower complication rate as compared to closed pleural biopsy with Abrahm's needle.

Vijaya D.,IInd main road | Harsha T.R.,AIMS | Nagaratnamma T.,Bowring And Lchospital
Journal of Clinical and Diagnostic Research | Year: 2011

Introduction: CHROM agar for speciation of Candida is a differential culture medium which facilitates the isolation and identification of some clinically important species. Materials and Methods: A total of 102 Candida species were isolated from various clinical specimens (100) including stool, sputum, nasal, oral, ear swabs, diabetic foot, skin and nail scrapings. Speciation of Candida was done using CHROM agar and conventional method simultaneously. Observations: Non albicans candida (NAC) predominated (54.1%) over Candida albicans (45.9%). Non albicans candida spp isolated were C.tropicalis (35.29%), C.krusei (10.78%), C.parapsilosis (7.84%), and C. dubliniensis (0.9%). Antifungal susceptibility testing was done using antimycotic sensitivity testing by disc diffusion method. Isolates were 100% sensitive to ketoconazole, clotrimazole, nystatin and amphotericin B. 87.5% of C.krusei, 36% C.tropicalis, 6.25%,C. albicans were resistant to itraconazole. 25% C.krusei and 8% C.tropicalis were resistant of fluconazole. C.dubliniensis was resistant to itraconozole only. Conclusion:The advantage of using CHROM agar is that it facilitates the isolation and identification of Candida to species level. The performance of CHROM agar exactly paralleled that of conventional methods. Use of this medium is rapid, technically simple and cost effective compared to time consuming technically demanding expensive conventional method. CHROM agar serves as a primary isolation and differentiation medium for clinical specimens that could allow mycology laboratories to rapidly identify Candida spp, enabling clinicians to choose appropriate antifungal agents,thus decreasing patients morbidity and mortality.

Frostick A.,Charles Darwin University | Frostick A.,Khan Research Laboratories | Bollhofer A.,Khan Research Laboratories | Parry D.,AIMS
Journal of Environmental Radioactivity | Year: 2011

Australian guidelines recommend that tailings materials from uranium (U) mining and milling be contained without any detrimental impact on the environment for at least 1000 years. Natural analogue sites are being investigated to determine if they can provide data on the rates of natural erosion processes which occur over these timescales, for input into predictive geomorphic computer models. This paper presents radionuclide, metal and stable lead (Pb) isotope data from sediment cores and surface soils in the vicinity of two mineralised areas in the Alligator Rivers Region. Surface scrapes from the natural Anomaly #2, south of the Ranger mineral lease, exhibit radiogenic 206Pb/ 207Pb and 208Pb/ 207Pb ratios, and elevated U and metal concentrations typical for a near surface U anomaly. In contrast, samples taken from the Koongarra mineral lease (KML) show radionuclide activity and metal concentrations similar to natural areas elsewhere in the Alligator Rivers Region and Pb isotope ratios are closer to present day average crustal ratios (PDAC), as the orebodies at KML are covered by surficial sand. A sediment core collected from Anbangbang Billabong, downstream of KML, exhibits small variations in Pb isotope ratios that indicate that approximately 1% of the upper sediments in the sediment core may be derived from material originating from the U anomaly at Koongarra. © 2010 Elsevier Ltd.

Kalra S.,Bharti Hospital | Kalra B.,Bharti Hospital | Agrawal N.,DOTC | Unnikrishnan A.,AIMS
Diabetology and Metabolic Syndrome | Year: 2011

This paper reviews the incidence, pathogenetic mechanisms and management strategies of diabetes mellitus in patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). It classifies patients based on the aetiopathogenetic mechanisms, and proposes rational methods of management of the condition, based on aetiopathogenesis and concomitant pharmacotherapy. © 2011 Kalra et al; licensee BioMed Central Ltd.

Kalra S.,Bharti Hospital | Unnikrishnan A.G.,AIMS | Agrawal N.,DOTC | Singh A.K.,Bharti Hospital
Recent Patents on Endocrine, Metabolic and Immune Drug Discovery | Year: 2011

The dipeptidyl peptidase-4 (DPP-4) inhibitors linagliptin, sitagliptin, saxagliptin, vildagliptin and alogliptin are being developed and have been approved for the treatment of type-2 diabetes. These agents may be used either as monotherapy for the treatment of type-2 diabetes or in combination with other anti-diabetic drugs. The present review highlights the use of linagliptin and other new (DPP-4) inhibitors in the management of type-2 diabetes. The review also highlights advantages, comparative pharmacokinetic, safety profile and other potential uses including potential newer indications of DPP-4 inhibitors and relevant patents. The other potential uses that are not restricted to diabetes include obesity, cardiovascular disease, neurological disease, hepatobiliary disease, wound healing, and other inflammatory illnesses. © 2011 Bentham Science Publishers.

Rallapalli S.,Bharathiyar University | Gondkar R.R.,AIT Inc | Ketavarapu U.P.K.,AIMS
Procedia Computer Science | Year: 2016

The critical challenge that the healthcare organizations are facing is to analyze the large-scale data. With the rapid growth of various healthcare applications, various devices used in healthcare generate varieties of data. The data need to be processed and effectively analyzed for better decision making. Cloud computing is a promising technology which can provide on-demand services for storage, processing and analyzing the data. The traditional data processing systems no longer has an ability to process such huge data. In order to achieve a better performance and to solve the scalability issues we need a better distributed system on cloud environment. Hadoop is a framework which can process large scale data sets on distributed environment. Hadoop can be deployed on cloud environment to process the large scale healthcare data. Healthcare applications are being supplied through internet and cloud services rather than using as traditional software. Healthcare providers need to have real time information to provide quality healthcare. This paper discuss on the impacts of data processing and analyzing large scale healthcare data on cloud computing environment. © 2016 The Authors. Published by Elsevier B.V.

Ajay B.,AIMS
Journal of South India Medicolegal Association | Year: 2014

Comparison of Radiographs is routinely used for identification of deceased all over the world. Even though dental radiographs are used most often, other x-rays have also been shown to be of use. In the present case, the review chest X-ray of a patient showed a radiographic picture at variance with the one taken only 28 days earlier. This aroused the suspicion of the clinician. Forensic comparison was used to resolve this issue. © 2014 South India Medico-Legal Association. All rights reserved.

Vijaya D.,AIMS | Sathish J.V.,AIMS | Janakiram K.,AIMS
Journal of Clinical and Diagnostic Research | Year: 2013

Aim: The Group A Streptococci (GAS) cause several suppurative and non-suppurative infections. GAS frequently gets colonized in the throat of asymptomatic school children. A preliminary study was conducted to identify the GAS carrier state in apparently healthy children who belonged to various schools which were located in and around the rural village, B.G.Nagara, Mandya Dist, Karnataka state, India. Material and Methods: Throat swabs were collected from 2000 asymptomatic school children who were aged 5-15 years. The beta haemolytic streptococci isolates were sero-grouped by agglutination tests by using specific antisera (HiStrep Latex Test, Hi-Media, Mumbai, India. Results: Out of the 44 (2.2%) beta haemolytic Streptococci which were isolated, 38 (86.36%) were GAS, 5 (11.36%) were Group C Streptococci and one (2.27%) was Group G Streptococcus. Among the 38 GAS positive children, 24 (63.16%) were transient carriers, 10(26.32%) were recurrent carriers and 4 (10.52%) were chronic carriers. The GAS chronic carriers were of the age group of 9-12 years. Conclusion: The present study showed the prevalence of GAS among the asymptomatic school children in this location. The chronic carriers were treated with azithromycin for 3 days. A bacteriological cure was confirmed by doing throat swab cultures at intervals of one month and four months after the treatment. Identification of the GAS carriers and treating them, not only prevents them from developing non-suppurative complications, but they also prevent the spread of GAS to their family members and other children.

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