Hardwick, MA, United States
Hardwick, MA, United States

Time filter

Source Type

Patent
Aileron Therapeutics | Date: 2016-09-08

The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyper-activation.


Patent
Aileron Therapeutics | Date: 2016-09-02

Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease. Also provided here in are methods of using such macrocycles in combination with at least one additional pharmaceutically active agent for treatment of disorders, for example for treatment of cancer.


Patent
Aileron Therapeutics | Date: 2017-05-24

The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.


Patent
Aileron Therapeutics | Date: 2016-04-08

The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.


Patent
Aileron Therapeutics | Date: 2016-04-21

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.


Patent
Aileron Therapeutics | Date: 2016-03-18

Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.


Patent
Aileron Therapeutics | Date: 2016-07-01

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.


Patent
Aileron Therapeutics | Date: 2016-04-07

The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.


Patent
Aileron Therapeutics | Date: 2016-04-07

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.


Patent
Aileron Therapeutics | Date: 2016-04-07

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.

Loading Aileron Therapeutics collaborators
Loading Aileron Therapeutics collaborators