Toyota, Japan

Aichi Gakusen University

www.gakusen.ac.jp/u/
Toyota, Japan

Aichi Gakusen University is a private university with campuses in Okazaki, Aichi and Toyota, Aichi, Japan. The school was established in 1966 as a women's college. Later it became co-educational. Wikipedia.

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Takemura H.,Aichi Gakusen University | Takemura H.,University of Shizuoka | Sakakibara H.,University of Miyazaki | Yamazaki S.,University of Shizuoka | Shimoi K.,University of Shizuoka
Current Pharmaceutical Design | Year: 2013

Endogenous estrogens, such as 17β-estradiol (E2), are implicated in the development of breast cancer. The putative mechanisms by which estrogens exert the carcinogenic effects have been recognized to involve the redox cycling of estrogen metabolites and subsequent estrogen-DNA adduct formation as well as the estrogen receptor-dependent pathway of estrogen-induced cell growth. The former pathway is regulated by phase I enzymes, mainly cytochrome P450 (CYP) 1A1, 1A2, and 1B1. Among them, CYP1B1 predominantly catalyzes the C4-position of E2 and forms carcinogenic 4-hydroxy-E2 (4-OHE2), whereas CYP1A1 and CYP1A2 convert E2 to noncarcinogenic 2-hydroxy-E2. Formed 4-OHE2 is further oxidized to semiquinones and quinones, which form DNA adducts, leading to mutagenic lesions. Consequently, CYP1B1 is highly expressed, and 4-OHE2 is predominantly detected in estrogen target neoplastic tissues. Moreover, invasion and metastasis are also involved in the development of breast cancer. Epidemiological studies suggest an inverse association between a higher intake of flavonoids and breast cancer risk. Flavonoids, which are widely distributed in the plant kingdom, have been recently reported as candidate compounds that can exert chemopreventive effects in estrogen-dependent or independent breast cancer. In this review, we provide a comprehensive overview of breast cancer and chemoprevention by flavonoids, mainly focusing on ER-mediated hormonal regulation, redox cycling of estrogen metabolites, and selective inhibition of CYP1B1. © 2013 Bentham Science Publishers.


Imaizumi M.,Aichi Gakusen University | Kimura M.,Gifu City Womens College
International Journal of Reliability, Quality and Safety Engineering | Year: 2017

As the technology has developed, cloud computing which is a kind of Internet-based computing has widely spread. In terms of operating cloud system in remote locations, there exist some problems when the failure of cloud system occurs. In such cases, workers need to go to the remote locations and maintain the system. This paper considers stochastic models of a redundant cloud system in remote locations. The cloud system has active devices and standby devices. We derive the steady-state availability and discuss optimal policies which maximize it. Finally, numerical examples are given. © 2017 World Scientific Publishing Company.


Hanzawa F.,Nagoya University of Arts and Sciences | Nomura S.,Nagoya University of Arts and Sciences | Sakuma E.,Nagoya University of Arts and Sciences | Uchida T.,Nagoya University of Arts and Sciences | And 2 more authors.
Journal of Nutrition | Year: 2013

We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of this study was to examine whether dietary sesame seed also increased vitamin K concentrations, because its metabolic pathway is similar to that of vitamin E. To test the effect of sesame lignan on vitamin K concentrations, male Wistar rats were fed a control diet or a diet with 0.2% sesamin (a sesame lignan) for 7 d in experiment 1. Liver phylloquinone (PK), menaquinone-4 (MK-4), and γ-tocopherol were greater in rats fed sesamin than in control rats. To test the effect of sesame seed on vitamin K concentrations, male Wistar rats were fed a control diet or a diet with 1, 5, or 10% sesame seed for 3 d in experiment 2. Liver and kidney PK and γ-tocopherol but not MK-4 were greater in rats fed sesame seed than in control rats, although differences in dietary amounts of sesame seed did not affect the PK concentrations. For further confirmation of the effect of sesame seed, male Wistar rats were fed a control diet or a diet with 20% sesame seed for 40 d in experiment 3. Kidney, heart, lung, testis, and brain PK and brain MK-4 were greater in rats fed sesame seed than in control rats. The present study revealed for the first time, to our knowledge, that dietary sesame seed and sesame lignan increase not only vitamin E but also vitamin K concentrations in rat tissues. © 2013 American Society for Nutrition.


Imaizumi M.,Aichi Gakusen University | Kimura M.,Gifu City Womens College
Proceedings - 19th ISSAT International Conference on Reliability and Quality in Design, RQD 2013 | Year: 2013

As the Internet and the cloud computing have developed, huge amounts of data have been generated and have been stored in the server. To execute the processing of huge amounts of data effectively, a distributed processing system has been widely used. This paper formulates stochastic models for a distributed processing system. A data is replicated and is divided into n small data respectively. Replicated n small data are executed with consistency. The mean time until the processing of a data is successful and an optimal policy which minimizes it is discussed. Finally, numerical examples are given.


Imaizumi M.,Aichi Gakusen University | Kimura M.,Gifu City Womens College
Proceedings - 21st ISSAT International Conference on Reliability and Quality in Design | Year: 2015

As the Internet technology has developed, not only the information system but also the control system which controls various devices have become connected with the Internet. The operational efficiency of a control system is improved by being connected with the Internet. However, it increases the risk of cyber attacks. Meanwhile, in terms of the control system, the real-time property which guarantees response within strict time constraints is required. This paper considers the optimal policy of a control system connected with the network. The control system consists of N units. If cyber attack cannot be detected, the system becomes failure. If the N-th operating unit cannot finish one processing until a time limit T, a processing of system interrupts. The mean time to system failure or interruption is derived. Further, the optimal policy which minimizes the cost effectiveness is discussed. Finally, numerical examples are given.


Imaizumi M.,Aichi Gakusen University | Kimura M.,Gifu City Womens College
RQD 2014 - Proceedings - 20th ISSAT International Conference Reliability and Quality in Design | Year: 2014

Recently, the case that malware enters into an organization's LAN through e-mail and so on, has become a serious problem. It is important to detect the attacks and to address them as soon as possible, however it takes a lot of time and cost to monitor and analyze the log data. Therefore, in terms of monitoring, it is necessary to implement it under appropriate management policy. This paper considers optimal monitoring policies for a system with cyber attack. One is the model where the loss cost between attack occurrence and its detection increases with time linearly, the other is the model where it increases with time non-linearly. The expected cost until the detection of attack is derived. Further, optimal policies which minimize the expected cost are discussed. Finally, numerical examples are given.


Imaizumi M.,Aichi Gakusen University | Kimura M.,Gifu City Womens College
Proceedings - 22nd ISSAT International Conference on Reliability and Quality in Design | Year: 2016

Recently, cloud computing which is a kind of Internet-based computing has been widely spread. In terms of operating cloud system in remote locations, there exist some problems when the failure of cloud system occurs. In such cases, workers need to go to the remote locations and maintain the system. This paper considers three stochastic models of a cloud system in remote locations. The cloud system has active devices and standby devices. We derive the steady-state availability and discuss a policy which maximizes it. Finally, a numerical example is given. © 2016, International Society of Science and Applied Technologies. All rights reserved.


Yamazaki S.,University of Shizuoka | Sakakibara H.,University of Miyazaki | Takemura H.,Aichi Gakusen University | Yasuda M.,University of Shizuoka | Shimoi K.,University of Shizuoka
Journal of Steroid Biochemistry and Molecular Biology | Year: 2014

Risk factors for breast cancer include estrogens such as 17β-estradiol (E2) and high stress levels. 4-Hydroxyestradiol (4-OHE2), a metabolite of E2 formed preferentially by cytochrome P450 1B1, is oxidized to E2-3,4-quinone, which reacts with DNA to form depurinating adducts that exert genotoxicity and carcinogenicity. Endogenous catecholamines such as adrenaline (A) and noradrenaline (NA) are released from the adrenal gland and sympathetic nervous system during exposure to stress. Here, we found that treatment with 4-OHE2 (3 μM) and NA (3 nM) significantly induced the phosphorylation of histone H2AX (γ-H2AX), one of the earliest indicators of DNA damage, and apurinic (AP) sites via the α2-adrenergic receptor (α2-AR) in human mammary epithelial MCF-10A cells. As an inverse association between a higher intake of flavonoids and breast cancer risk has previously been suggested from epidemiological studies, we investigated the effects of quercetin-3-O- glucuronide (Q3G), a circulating metabolite of quercetin in the blood, on 4-OHE2- and NA-induced γ-H2AX and AP sites. Q3G (0.1 μM) suppressed their induction and inhibited the binding of [3H]-NA to α2-AR. These results suggest that Q3G acts as an α2-AR antagonist and that it could be used as a chemopreventive agent for stress-promoted breast cancer. © 2014 Published by Elsevier Ltd.


Tatsuda K.,Aichi Gakusen University | Oishi Y.,Daido University
IEEJ Transactions on Electronics, Information and Systems | Year: 2016

Onomatopoeia is a powerful means to convey characteristics of sounds and also important for designing sounds. We conducted an experiment wherein 493 people, aged 7-8 1 years, and 376 kindergarteners, aged 3-6 years, were requested to imitate pure sounds of 62.5 Hz, 500 Hz, and 4 kHz with onomatopoeic voices. We analysed differences in trends of onomatopoeic expressions based on gender and age. Various onomatopoeic voices were produced by the subjects, many of which were those starting with consonants "P" or "B" followed by long vowels. There were significant gender differences in their starting consonants at 500 Hz and 4 kHz, whereas age differences were remarkable at 62.5 Hz and 500 Hz. A significant difference was observed in both gender and age at 500 Hz for long vowels. The onomatopoeic voices indicated by the kindergarteners had a lot of variations, among which their consonants in particular were found to be significantly different from that of adults at all frequencies. Noticeable gaps were found between three-year-old children and adults in vowels, but the gaps in vowels of the children became closer to those of adults as they aged. © 2016 The Institute of Electrical Engineers of Japan.


Konomi A.,Seitoku University | Konomi A.,Aichi Gakusen University | Yokoi K.,Seitoku University
British Journal of Nutrition | Year: 2011

Patients with Fe-deficiency anaemia are often afflicted by hypotension. However, the mechanism of secondary hypotension in Fe-deficiency anaemia is unknown. To investigate the pathogenesis of secondary hypotension in Fe-deficiency anaemia, we examined the effects of Fe deprivation on plasma aldosterone concentration and blood pressure in rats. A total of forty 4-week-old male Sprague-Dawley rats were assigned into four treatment groups of ten each for the 4-week study: Fe-deficient group (FD), Zn-deficient group (ZD), Fe/Zn-deficient group (FZD) and control group (CON). At days 26 and 27, blood pressure was measured by the tail-cuff method. Plasma aldosterone concentration was determined by ELISA. The data were analysed by Tukey's multiple comparison test. Rats in the FZD had significantly lower mean blood pressure (P<001) and diastolic blood pressures (P<005) and plasma aldosterone concentration (P<001) compared to the CON. These results suggest that blood pressure is decreased in Fe-deficiency anaemia combined with Zn deficiency partly due to decreased circulating aldosterone concentrations in addition to decreased haematocrit. © 2010 The Authors.

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