Aichi Bunkyo Womens College

Okazaki, Japan

Aichi Bunkyo Womens College

Okazaki, Japan
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PubMed | Nagoya University of Arts and Sciences, Aichi Gakusen University, Yokohama Stroke and Brain Center, Nagoya Bunri University and 4 more.
Type: | Journal: Open access journal of sports medicine | Year: 2016

We studied changes in blood markers of 18 nonprofessional, middle-aged runners of a 2-day, 130 km ultramarathon. Blood was sampled at baseline, after the goals on the first and second day, and at three time points (1, 3, and 5/6 days) after the race. Blood indices showed three patterns. First pattern indices showed essentially no changes after the two goals and after the race, including red blood cell indices, gamma-glutamyl transferase, and tumor necrosis factor-. Second pattern markers, including the majority of indices, were elevated during the race (and also after the race for some parameters) and then returned to baseline afterward, including hemolysis/red blood cell destruction markers (indirect bilirubin) and an iron reservoir index (ferritin), muscle damage parameters (uric acid, creatine kinase, lactate dehydrogenase, and aspartate aminotransferase), renal function markers (creatinine and blood urea nitrogen), liver injury index (alanine aminotransferase), lipid metabolism indices (free fatty acid), reactive oxygen species and inflammation parameters (white blood cells, interleukin-6, and C-reactive protein), and energy production and catecholamines (adrenaline, noradrenaline, and dopamine). Third pattern index of a lipid metabolism marker - triglyceride - decreased during the race periods and started returning to baseline from then onward. Some hormonal markers such as insulin, leptin, and adiponectin showed unique patterns. These findings appeared informative for nonprofessional athletes to know about an optimal physical activity level, duration, and total exercise for elevating physical performance and monitoring physical/mental conditioning as well as for prevention of overtraining and physical injuries.


Wada K.,Gifu University | Nakamura K.,Gifu University | Tamai Y.,Gifu University | Tsuji M.,Gifu University | And 6 more authors.
Nutrition Journal | Year: 2011

Background: Few studies have examined whether dietary factors might affect blood pressure in children. We purposed to investigate whether seaweed intake is associated with blood pressure level among Japanese preschool children. Methods. The design of the study was cross-sectional and it was conducted in autumn 2006. Subjects were healthy preschoolers aged 3-6 years in Aichi, Japan. Blood pressure and pulse were measured once by an automated sphygmomanometer, which uses oscillometric methods. Dietary data, including seaweed intake, were assessed using 3-day dietary records covering 2 consecutive weekdays and 1 weekend day. Of a total of 533 children, 459 (86.1 percent) agreed to be enrolled in our study. Finally, blood pressure measurement, complete dietary records and parent-reported height and weight were obtained for 223 boys and 194 girls. Results: When we examined Spearman's correlation coefficients, seaweed intake was significantly negatively related to systolic blood pressure in girls (P = 0.008). In the one-way analysis of covariance for blood pressure and pulse after adjustments for age and BMI, the boys with the lowest, middle and highest tertiles of seaweed intake had diastolic blood pressure readings of 62.8, 59.3 and 59.6 mmHg, respectively (P = 0.11, trend P = 0.038). Girls with higher seaweed intake had significantly lower systolic blood pressure readings (102.4, 99.2 and 96.9 mmHg for girls with the lowest, middle and highest tertiles of seaweed intake, respectively; P = 0.037, trend P = 0.030). Conclusion: Our study showed that seaweed intake was negatively related to diastolic blood pressure in boys and to systolic blood pressure in girls. This suggests that seaweed might have beneficial effects on blood pressure among children. © 2011 Wada et al; licensee BioMed Central Ltd.


Tsuji M.,Gifu University | Nakamura K.,Gifu University | Tamai Y.,Gifu University | Wada K.,Gifu University | And 5 more authors.
European Journal of Clinical Nutrition | Year: 2012

Background/Objectives:Diets rich in plant-based foods such as vegetables, fruits and soy foods have been suggested to have beneficial effects on health. However, phytochemicals contained in plant-based foods are generally bitter and acrid. We investigated whether intake of vegetables, fruits and soy foods is associated with sensitivity to bitterness and reluctance to eat new foods (food neophobia) in Japanese preschool children.Subjects/Methods:Subjects of this cross-sectional study were healthy Japanese, 167 boys and 156 girls, aged 4-6 years. Intake of vegetables, fruits and soy foods was estimated from 3-day dietary records. Subjects were classified as either tasters or non-tasters of 6-n-propylthiouracil (PROP) based on their ability to taste 0.56 mmol/l PROP. Information on each childs age, height, weight, food neophobia status and food variety, as well as maternal diet and parental control over the childs eating, was obtained by a parent-administered questionnaire. Food neophobia was assessed using the Child Food Neophobia Scale (CFNS).Results:A high intake of vegetables was significantly associated with a low CFNS score in boys after controlling for covariates (P=0.0008). Among the boys, soy food intake was significantly higher in PROP non-tasters than in tasters, except those with low CFNS scores (P=0.0019). High intake of soy foods was significantly associated with a low neophobia score in PROP tasters but not in non-tasters (P=0.0024).Conclusions: These data suggest that sensitivity to bitter taste and food neophobia may influence the consumption of vegetables and soy foods among Japanese preschool boys. © 2012 Macmillan Publishers Limited All rights reserved.


Wada K.,Gifu University | Nakamura K.,Gifu University | Tamai Y.,Gifu University | Tsuji M.,Gifu University | And 4 more authors.
Annals of Epidemiology | Year: 2013

Purpose: We aimed to assess the associations of sex, age, body mass, sex steroid hormones, and lifestyle factors with the levels of melatonin in young children. Methods: This study followed a cross-sectional design and was conducted two preschools in Japan. Subjects were 235 boys and 203 girls, aged 3-6 years. Information related to demographics, body mass, and lifestyle factors was obtained from parent-administered questionnaires. The levels of 6-sulfatoxymelatonin and dehydroepiandrosterone in first-void morning urine were measured by radioimmunoassay. Urinary estrone, estradiol, testosterone, and 5-androstene-3β, 17α diol levels were measured by liquid chromatography-electrospray ionization tandem mass spectrometry. Results: The creatinine-corrected 6-sulfatoxymelatonin levels and the estimated value of 6-sulfatoxymelatonin excretion were higher in girls than in boys. After adjustments for age, the creatinine-corrected 6-sulfatoxymelatonin was negatively associated with weight and body mass index among boys and with weight and height among girls. However, the estimated value of 6-sulfatoxymelatonin excretion was not associated with any indices of body mass. No significant relationships of urinary sex steroids, light exposure at night, sleep time, sedentary lifestyles, or passive smoking with urinary 6-sulfatoxymelatonin were observed. Conclusions: Our findings suggest that melatonin levels depend on sex and body size among young healthy children. Our results should be confirmed in future researches. © 2013 Elsevier Inc.


Nakamura K.,Gifu University | Wada K.,Gifu University | Sahashi Y.,Gifu University | Tamai Y.,Gifu University | And 5 more authors.
Public Health Nutrition | Year: 2013

Objective Increasing childhood asthma rates may be due to changing dietary lifestyle. We investigated the association of dietary intake of antioxidant vitamins and fatty acids with asthma in Japanese pre-school children. Design Cross-sectional study. Setting School-based survey on lifestyle/diet and health status in children in Japan. Subjects Parents of 452 children aged 3-6 years completed a questionnaire on the children's and parents' lifestyle and demographics. Children were classified into asthma cases and non-asthma cases in accordance with the ATS-DLD (American Thoracic Society and Division of Lung Diseases of the National Heart, Lung, and Blood Institute) questionnaire. Children's diet was assessed using a 3 d dietary record completed by parents. Children's age, sex, BMI, history of food allergy, maternal age, parental history of allergy, maternal education, family size and second-hand smoking were included as covariates. Logistic regression models were used to examine the association between children's diet and asthma. Results Compared with children with the lowest intake tertile for vitamin C and vitamin E, those in the highest were significantly inversely associated with asthma; adjusted OR (95 % CI) were 0·35 (0·14, 0·88) and 0·32 (0·12, 0·85), respectively. A statistically significant trend was also observed. Fruit intake showed an inverse but insignificant association with asthma. There were no associations of any type of fatty acids with asthma. Conclusions These data suggest that children with high intakes of vitamins C and E may be associated with a reduced prevalence of asthma. © 2012 The Authors.


Wada K.,Gifu University | Nakamura K.,Gifu University | Masue T.,Gifu University | Sahashi Y.,Gifu University | And 2 more authors.
American Journal of Epidemiology | Year: 2011

The authors investigated whether soy intake is associated with sex steroid levels in Japanese children. This cross-sectional study was conducted in autumn 2006. Subjects were substantially healthy preschoolers, 230 boys and 198 girls, aged 3-6 years. Dietary data, including soy intake, were assessed using 3-day dietary records. Each child's dietary intake was controlled for total energy intake using the Willett method (Nutritional Epidemiology. Oxford, United Kingdom: Oxford University Press; 1990:245-271). Urinary estrone, estradiol, testosterone, and 5-androstene-3β,17α diol levels measured using liquid chromatography-electrospray ionization tandem mass spectrometry, and urinary dehydroepiandrosterone level measured with a radioimmunoassay, were adjusted for urinary creatinine levels. In the analysis of covariance for sex steroids after adjustments for age and body mass index, soy intake was significantly negatively related to estrone and estradiol in boys and positively related to testosterone and 5-androstene-3β,17α diol in girls. Isoflavone had a significant tendency to be negatively associated with estradiol in boys and to be positively associated with testosterone in girls. Total energy intake was not associated with any sex steroids in boys or girls. These results suggest that soy intake might affect the secretion or metabolism of sex steroids in childhood and that the effects might differ by sex. © 2011 The Author.


Tamai Y.,Gifu University | Wada K.,Gifu University | Tsuji M.,Gifu University | Nakamura K.,Gifu University | And 5 more authors.
American Journal of Hypertension | Year: 2011

Background An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid. Until now, the association between the intake of these vitamins and blood pressure has been examined only in adult populations. We purposed to examine the association between dietary intake of these three vitamins and blood pressure of young children. Methods We conducted a cross-sectional study at Japanese preschools in 2006. Blood pressure was measured among 418 children aged 3-6 years. Diets including vitamins were assessed by a 3-day dietary record. We compared the blood pressure levels among the four groups defined according to quartile of energy-adjusted vitamin intake by using analysis of covariance after controlling for age, sex, and body mass index. Results The mean systolic blood pressure was 6.6 mm Hg lower and the mean diastolic blood pressure was 5.7 mm Hg lower in the highest quartile than in the lowest quartile of vitamin B12 intake (P for trend was <0.001 and 0.006, respectively). The mean systolic blood pressure was 4.1 mm Hg lower in the highest quartile than in the lowest quartile of folic acid intake (P for trend = 0.004). Vitamin B6 intake was not significantly associated with blood pressure. Conclusions The data suggest that high intakes of folic acid and vitamin B12 are associated with lower levels of blood pressure among preschool children. © 2011 American Journal of Hypertension, Ltd.


Wada K.,Gifu University | Nakamura K.,Gifu University | Tamai Y.,Gifu University | Tsuji M.,Gifu University | And 3 more authors.
Cancer Causes and Control | Year: 2012

Purpose: We investigated whether seaweed intake is associated with sex steroid levels in young Japanese children. Methods: The design of the study was cross-sectional and it was conducted in October-November 2006. Subjects were substantially healthy preschoolers, 230 boys and 198 girls, aged 3-6 years. Dietary data, including seaweed intake, were assessed using 3-day dietary records covering 2 consecutive weekdays and 1 weekend day. Urinary estrone, estradiol, testosterone, and 5-androstene-3β,17α diol levels were measured by liquid chromatography-electrospray ionization tandem mass spectrometry. Urinary dehydroepiandrosterone level was measured with a radioimmunoassay. Steroid hormones were adjusted for urinary creatinine levels. Results: Spearman's correlation coefficient between seaweed intake and estrone level was -0.144 (p = 0.030) in boys and -0.147 (p = 0.041) in girls after adjustments for age, BMI, and total energy intake. Seaweed intake was neither associated with estradiol, testosterone, 3β,17α-AED nor with DHEA among boys and girls. Conclusions: The negative association between seaweed intake and estrone level suggests that dietary seaweed intake might affect estrogen metabolism in childhood. © 2011 Springer Science+Business Media B.V.


Wada K.,Gifu University | Nakamura K.,Gifu University | Tamai Y.,Gifu University | Tsuji M.,Gifu University | And 3 more authors.
Annals of Epidemiology | Year: 2013

Purpose: We aimed to investigate the associations of sleep disturbance and sleep time with behavioral problems and to assess whether endogenous melatonin was associated with sleep-related factors and behavioral problems. Methods: Subjects were 234 boys and 203 girls, aged 3-6years, in a cross-sectional study in Japan in 2006. Information related to children's sleep disturbance, sleep time, and behavioral problems was obtained from parent-administered questionnaires. Children's behavioral problems were assessed by the Strengths and Difficulties Questionnaire. The 6-sulfatoxymelatonin levels in first-void morning urine were measured by radioimmunoassay. Results: After multiple adjustments for covariates, children who often snore at night (P= .011), awake at night (P= .019), and looked tired in the daytime (P= .041) had a higher total difficulties score. Earlier time of waking (trend P= .021) and earlier time for bed (trend P= .014) were associated with a lower total difficulties score. Children with higher creatinine-corrected 6-sulfatoxymelatonin had lower total difficulties scores (trend P= .011). There were no associations between creatinine-corrected 6-sulfatoxymelatonin and sleep-related factors. Conclusions: Sleep disturbance, later times of sleeping and waking up, and lower melatonin levels might be involved in the development of pediatric behavioral disorders. © 2013 Elsevier Inc.


Nishii T.,Mie University | Sukigara E.,Aichi Bunkyo Womens College | Abe R.,Shimano Inc. | Takaishi T.,Nagoya City University
Japanese Journal of Physical Fitness and Sports Medicine | Year: 2012

The purpose of this study was to reveal physiological conditions of commuter cyclist from the standpoint of multiple approaches. Ten male employees (37 ± 9 yr) who usually commute by bicycle participated in this study. Global Positioning System (GPS) was used to analyze their commuting route three-dimensionally. And heart rate was recorded simultaneously to determine their exercise intensity. Blood test, oral glucose tolerance test (OGTT), and maximal aerobic test was conducted in our laboratory. Semantic differential method (SD) questionnaire was conducted to clarify their feelings during and after their commute. The results of blood test and OGTT showed that all of determined values were good and no one exceeded the standard value. GPS log showed that subjects covered 13.3 ± 7.2 km and 40 ± 20 minute with integrating 201 ± 114 meter altitude gain per commute. Heart rate data showed 129 ± 12 bpm per commute. However, subjects demonstrated higher peak heart rate during their commute ranged between 157 and 181 bpm, we determined details by frequency distribution method. The data revealed that commuter cycling was consisted by aerobic exercise with intermittent vigorous intensity exercise. Despite of such a hard exercise cycling to work, the result of SD questionnaire indicated that subjects felt briskness with less tiredness when they commute. Commuter cycling with a higher than moderate exercise intensity, could have good physical and mental effects for employees.

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