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Bozo I.Y.,Moscow State University | Zorin V.L.,Human Stem Cells Institute | Eremin I.I.,Ai Burnasyan Federal Medical Biophysical Center | Deev R.V.,Kazan Federal University | And 3 more authors.
Genes and Cells | Year: 2014

Multipotent mesenchymal stromal cells (MMSC) derived from various intraoral sources attracts attention of an increasing number of researchers due to availability and some features making them different from MMSC of bone marrow or adipose tissue. The review describes the main intraoral sources, characterizes their anatomical, topographical and histological peculiarities which may influence on MMSC morphofunctional profile. In comparative aspect we systematized the principal data concerning properties of MMSC derived from gingiva, buccal mucosa; periodontal ligament, dental pulp, apical papilla, jaw periosteum. It is not possible to compare MMSC of various intraoral sources under some parameters because of absence appropriate experimental findings. Some additional difficulties are caused by contradictions in published materials that are discussed in the review as well. Source

Deev R.V.,Kazan Federal University | Mavlikeev M.O.,Kazan Federal University | Bozo I.Ya.,Moscow State University | Pulin A.A.,Ai Burnasyan Federal Medical Biophysical Center | Eremin I.I.,Ai Burnasyan Federal Medical Biophysical Center
Genes and Cells | Year: 2014

Genetic disorders primarily affecting skeletal muscles can be caused by dysfunction of more than 30 genes. To date there is no effective etiotropic and pathogenetic treatment of such disorders. Investigators focus on search for new therapeutic agents based on gene and cell technologies, small molecules as well. There are numerous preclinical and several dozens of clinical studies in the world. Unfortunately tested technologies did not lead to significant advance in treatment of patients with such disorders. At the same time resulting data allow to determine the most feasible directions of future development combining of genome correction methods with cell delivery of corrected genome to skeletal muscles. This review is intended to give general information about etiology of skeletal muscles genetic disorders, the main directions of biotechnological development and results of the clinical studies. Source

Kotenko K.V.,Ai Burnasyan Federal Medical Biophysical Center | Eremin I.I.,Ai Burnasyan Federal Medical Biophysical Center | Moroz B.B.,Ai Burnasyan Federal Medical Biophysical Center | Bushmanov A.Ju.,Ai Burnasyan Federal Medical Biophysical Center | And 10 more authors.
Cellular Transplantation and Tissue Engineering | Year: 2012

The treatment of patients with radiation burns and their effects is difficult. The basis for therapeutic strategy is surgical techniques, use of which is not always effective. Moreover, surgical methods are not always feasible in its entirety because of physical condition of patients and anatomical features of affected area. In this regard, new effective therapeutic approaches are developing. Use of cellular technology is one of the most promising approaches. Burnazyan FMBC specialists have successful experience of treatment patients with local radiation injury using cell preparations from multipotent mesenchymal stromal cells in the clinical trial, which resulted in the present article. Source

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