Ahwaz Jondishapur University of Medical science

Ahvāz, Iran

Ahwaz Jondishapur University of Medical science

Ahvāz, Iran
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Zahra A.,Ahwaz Jondishapur University of Medical science | Fateme G.,Health Science University | Mohamadreza A.,Ahwaz Jondishapur University of Medical science
African Journal of Pharmacy and Pharmacology | Year: 2010

Bacterial vaginosis is a change of vaginal flora in which the normal lactobacilli flora is replaced by an overgrowth of Gardnerella vaginalis and anaerobic bacteria. Bacterial vaginosis is the most common cause of vaginal infection in women during their reproductive age. The relationship between bacterial vaginosis and increase of vaginal pH is suggested by the use of intravaginal acidification substances as a way for normalization of vaginal flora and treatment of bacterial vaginosis. The purpose of this study was to compare the effect of vitamin C vaginal tablet and metronidazole vaginal gel in treatment of bacterial vaginosis in patient referring to Ahwaz Amir Al Momenin hospital in Ahwaz city, Iran. In this randomized clinical trial 60 non-pregnant women aged between 15 - 45 years with confirmed diagnosis of bacterial vaginosis by Amsel criteria were randomly assigned to receive either 250 mg vitamin C tablet via vaginal route once daily for 6 days (n = 30) or 5 gm of 0.75% vaginal gel metronidazole once daily for 5 days (n = 30). The results of both groups compared for demographic characteristic, contraceptive and education level. The cure rate evaluated in both groups after two (1st and 2nd weeks) follow up visits. For statistical analysis, descriptive statistics, χ2 and Fisher's exact test performed. The study shows that cure rate after 1 week in vitamin C vaginal tablet group was 76.7% and in metronidazole vaginal gel group was 80% and after 2 weeks, cure rate was 9.5 and 5% respectively. Vitamin C vaginal tablet 250 mg is as effective as metronidazole vaginal gel for treatment of bacterial vaginosis. © 2010 Academic Journals.


Mansouri E.,Ahwaz Jondishapur University of Medical science | Panahi M.,Ahwaz Jondishapur University of Medical science | Ghaffari M.A.,Ahwaz Jondishapur University of Medical science | Ghorbani A.,Golestan University of Medical Sciences
Iranian Biomedical Journal | Year: 2011

Background: This study examined the effect of grape seed proanthocyanidin extract (GSPE) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. Methods: Thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg GSPE for 6 weeks. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg/kg body weight). Rats with fasting blood glucose levels above 250 mg/dl were used as diabetic animals. The first 24-hour urinary albumin excretion (UAE) was measured two weeks after diabetes induction and then each week until the end of the experimental period in all groups. Lipid peroxidation content and activities of catalase, superoxide dismutase and glutathione peroxidase were measured in kidney homogenate supernatants. Statistical significance of differences was assessed with one-way ANOVA by SPSS followed by Tukey's t-test. P<0.05 was assumed statistically significant. Results: UAE in diabetic nephropathy rats were significantly higher than in control. In addition, an increase in lipid peroxidation content and decrease in catalase, superoxide dismutase and glutathione peroxidase activities in kidney of diabetic nephropathy rats were observed. The GSPE administration did not affect on body weight, but significantly decreased lipid peroxidation and augmented the activities of antioxidant enzymes studied in kidney of diabetic nephropathy rats as well as reduced UAE and decreased kidney weight. Conclusion: The results suggested that GSPE could ameliorate diabetic nephropathy rats through reduction of oxidative stress and increase in renal antioxidant enzyme activity.


Aberomand M.,Ahwaz Jondi Shapur University of Medical science | Aberomand M.,Ahwaz Jondishapur University of Medical science | Aberomand S.,Ahwaz Jondi Shapur University of Medical science | Aberomand S.,Ahwaz Jondishapur University of Medical science | And 10 more authors.
Biochemical and Cellular Archives | Year: 2011

Beta-galactosidases (beta-D-galactoside-galactohydrolases, lactases) (EC:3.2.1.23) are enzymes found in most living beings such as plants, bacteria, fungi and animals as well as human placenta. Beta-galactosidase is important industrial enzyme used for the hydrolysis of lactose from milk. In this study, we partially purified three isoenzymes of beta-galactosidases from human placenta. The partial purified human placental enzyme exhibited high activity at 25°C. The beta galactosidase activities showed 8 μ/ml, 7μ/ml and 6μ/ml and specific activities obtained 8.05 μ/mg, 83.66 μ/mg and 24.27 μ/mg respectively. These results suggest that these fractions are three enzymes with difference structure.


PubMed | Golestan University of Medical Sciences and Ahwaz Jondishapur University of Medical science
Type: Journal Article | Journal: Iranian biomedical journal | Year: 2011

This study examined the effect of grape seed proanthocyanidin extract (GSPE) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats.Thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg GSPE for 6 weeks. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg/kg body weight). Rats with fasting blood glucose levels above 250 mg/dl were used as diabetic animals. The first 24-hour urinary albumin excretion (UAE) was measured two weeks after diabetes induction and then each week until the end of the experimental period in all groups. Lipid peroxidation content and activities of catalase, superoxide dismutase and glutathione peroxidase were measured in kidney homogenate supernatants. Statistical significance of differences was assessed with one-way ANOVA by SPSS followed by Tukeys t-test. P < 0.05 was assumed statistically significant.UAE in diabetic nephropathy rats were significantly higher than in control. In addition, an increase in lipid peroxidation content and decrease in catalase, superoxide dismutase and glutathione peroxidase activities in kidney of diabetic nephropathy rats were observed. The GSPE administration did not affect on body weight, but significantly decreased lipid peroxidation and augmented the activities of antioxidant enzymes studied in kidney of diabetic nephropathy rats as well as reduced UAE and decreased kidney weight.The results suggested that GSPE could ameliorate diabetic nephropathy rats through reduction of oxidative stress and increase in renal antioxidant enzyme activity.


Pirbalouti A.G.,Islamic Azad University | Pirbalouti A.G.,University of Massachusetts Amherst | Siahpoosh A.,Ahwaz Jondishapur University of Medical science | Setayesh M.,Ahwaz Jondishapur University of Medical science | Craker L.,University of Massachusetts Amherst
Journal of Medicinal Food | Year: 2014

Total phenolic and flavonoid contents and antioxidant activity of four Iranian herbs (Lamiaceae) were investigated. The antioxidant activity of methanol extracts of thyme (Thymus daenensis Celak.), Bakhtiari savory (Satureja bachtiarica Bung.), dragonhead (Dracocephalum multicaule Montbr & Auch), and woundwort (Stachys lavandulifolia Vahl.) was evaluated by measuring 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP), and trolox equivalent antioxidant capacity (TEAC). A comparison of all plant extracts in the DPPH assay indicated that dragonhead and thyme were the most effective free radical scavenging agents. Thyme demonstrated a relatively strong antioxidant activity in both the FRAP and TEAC assays. The total phenolic content of all the extracts ranged from 99 to 208 mg TAE/g extract with thyme exhibiting the highest phenolic content. The flavonoid content of the extracts, which ranged from 10.1 to 22.2 rutin equivalents/g of extract, was highest in dragonhead. A positive correlation was noted between the total phenolic content and antioxidant activity in both the FRAP and TEAC assays, while no significant correlation was observed between the DPPH, TEAC, and FRAP assay and total flavonoid, suggesting that the level of antioxidant activity in these plants varies greatly, but the total phenolic in the plant extracts provided a substantial antioxidant activity. Experimental results indicate that thyme and dragonhead extracts could be an important dietary source of phenolic compounds with high antioxidant capacity. © Copyright 2014, Mary Ann Liebert, Inc.


Soltanzadeh M.,Ahvaz Jundishapur University of Medical Sciences | Aberomand M.,Toxicology research center and Ahwaz Jondishapur University of Medical science | Aberomand S.,Ahwaz Jondishapur University of Medical science | Moghimi N.,Ahwaz Jondishapur University of Medical science | And 2 more authors.
Biochemical and Cellular Archives | Year: 2012

Succinylcholine is a depolarizing neuromuscular blocking drug, which is rapidly hydrolyzed by the enzyme pseudocholinesterase (EC 3.1.1.8). Deficiency of this enzyme can lead to prolonged apnea in patients who receive succinylcholine. Calibri (body) .The aim of this study was to estimate the serum level of plasma pseudocholinesterase activity of patients in Golesan hospital. Morning serums of 89 operated patients from Golesan Hospital were screened for their pseudocholinesteraseactivity, keeping 27 as controls using acetylcholine as a substrate. Serum pseudocholinesterase activity was measured in 89subjects undergone surgery.


Aberomand M.,Ahwaz Jondishapur University of Medical science | Rostemi M.,Ahwaz Jondishapur University of Medical science | Mohamadi M.A.,Ahwaz Jondishapur University of Medical science | Aberomand S.,Ahwaz Jondishapur University of Medical science | And 3 more authors.
Biochemical and Cellular Archives | Year: 2011

Acid phosphatase (EC: 3.1.3.4) is enzyme that can be found in most living beings and in the animals, plants and Human, its activity has been detected in several tissues such as prostate, liver, spleen and bone. The major forms are coded for by different gene, and also possess different molecular weights and structure. The isoenzyme of acid phosphatase was separated and purified from Human placental to homogeneity by chromatography on Sephadex G-150 superfine.

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