Idani E.,Ahwaz Jondishapour University of Medical science |
Ahmadzadeh A.,Ahwaz Jondishapour University of Medical science |
Yadollahzadeh M.,Shahid Beheshti University of Medical Sciences |
Heybar H.,Ahwaz Jondishapour University of Medical science |
And 2 more authors.
Acta Medica Iranica | Year: 2012
We aimed to evaluate clinical, high resolution computed tomography (HRCT) and pulmonary function test (PFT) findings after 18-23 years of exposure in veterans of sulphur mustard (SM) exposure. We performed a cross-sectional study of 106 patients. Inclusion criteria were 1: documented exposure to SM as confirmed by toxicological analysis of their urine and vesicular fluid after exposure 2: single exposure to SM that cause skin blisters and subsequent transient or permanent sequel. Cigarette smoking and pre-exposure lung diseases were of exclusion criteria. After taking history and thorough respiratory examination, patients underwent high resolution computed tomography and spirometry. Clinical diagnoses were made considering the findings. More than 85% of the patients were complaining of dyspnea and cough. Obstructive pattern (56.6%) was main finding in spirometry followed by restrictive and normal patterns. HRCT revealed air trapping (65.09%) and mosaic parenchymal attenuation patterns (58.49%) as most common results. Established diagnoses mainly were chronic obstructive pulmonary disease (COPD) (54.71%), bronchiolitis obliterans (27.35%) and asthmatic bronchitis (8.49%). There were not any significant association between the clinical findings and results of PFT and HRCT imaging and also between PFT and HRCT findings (P-values were more than 0.05). Considering debilitating and progressive nature of the respiratory complications of SM exposure, attempts are needed for appropriate diagnosis and treatment. © 2012 Tehran University of Medical Sciences. All rights reserved.
Dehdashti H.,Golestan University of Medical Sciences |
Dehdashtian M.,Golestan University of Medical Sciences |
Rahim F.,Ahwaz Jondishapour University of Medical science |
Payvasteh M.,Ahwaz Jondishapour University of Medical science
Saudi Journal of Gastroenterology | Year: 2011
Background/Aim: This study was conducted to provide sonographic measurements of the abdominal esophagus length in neonates and infants with and without gastroesophageal reflux disease (GERD) and to investigate its diagnostic value. GERD severity was also evaluated and correlated with esophageal length. It is a prospective case-control study. Materials and Methods: This prospective case-control study comprised 235 neonates and infants (120 without reflux and 115 with reflux). There were 40 children without reflux in each of three age categories: less than 1 month, 1-6 months, and 6-12 months. Of the children with reflux, 40 were less than 1 month old; 37, 1-6 months; and 38, 6-12 months. The abdominal esophagus was measured from its entrance into the diaphragm to the base of gastric folds in fed infants. GERD was sonographically diagnosed and confirmed by a barium meal. The number of refluxes during a 10-min period were recorded. Results: Neonates and infants with reflux had a significantly shorter abdominal esophagus than subjects without reflux: the mean difference in neonates, 4.65 mm; 1-6 months, 4.57 mm; 6-12 months, 3.61 mm. Conclusions: Children with severe reflux had a shorter esophagus compared with those with mild and moderate reflux only in the neonate group. Therefore, thinking of GERD and carefully looking for its symptoms is necessary to avoid unnecessary utilization of healthcare resources in children with severe reflux.
Arzi A.,Ahwaz Jondishapour University of Medical science |
Ahamehe M.,Ahwaz Jondishapour University of Medical science |
Sarahroodi S.,Qom University of Medical Sciences
Pakistan Journal of Biological Sciences | Year: 2011
Epilepsy an important CNS (Central Nervous System) problem that about 1% f worlds population suffer of it. The aim of study was to evaluate of anticonvulsant effect of hydroalcoholic extract of Lavandula officinalis. In this study, anticonvulsant activity of the hydroalcoholic extract of Lavandula officinalis (L. officinalis) was studied against chemoconvulsant-induced seizures in male mice. Lavandula officinalis (100, 200, 400, 600 and 800 mg kg -1), diazepam (0.15 mg kg -1) and normal saline (10 mL kg -1) were injected intraperitoneally, respectively in different groups of mice, 30 min before nicotine (5 mg kg -1 i.p.). The onset time intensity and duration of convulsions and the percentage of death were recorded. Also the time-response (0, 15, 30, 45, 60 min before nicotine injection) for most effective dose of plant extract (600 mg kg -1) was investigated. The results showed that hydroalcoholic extract of Lavandula officinalis had anticonvulsant effect. The most effective dose of plant extract was 600 mg kg -1. In time-response study for the most effective dose of extract (600 mg kg -1), the onset, duration and intensity of convulsion significantly (p<0.05) increased, decreased and decreased, respectively for all tested times. The best response observed in 30, 45 and 60 min. The results showed significant anticonvulsant effect for hydroalcoholic extract of Lavandula. © 2011 Asian Network for Scientific Information.
Izadpanah M.,Ahwaz Jondishapour University of Medical science |
Mohammadi M.,Tehran University of Medical Sciences |
Khalili H.,Tehran University of Medical Sciences |
Faramarzi M.A.,Tehran University of Medical Sciences
Journal of Comparative Effectiveness Research | Year: 2016
Background: Association between thrombosis pathogenesis and inflammatory conditions has been reported. Also inflammatory biomarkers have been proposed for prediction of thrombosis events. Objectives: Effects of different methods of heparin administration (subcutaneous vs continuous infusion) as thromboprophylaxis on the biomarkers of thrombosis have been evaluated. Methods: Serum levels of hsCRP, IL-10 and P-selectin as the biomarkers of thrombosis were measured at baseline, days 3 and 7 during the patients' hospitalization period. Results: Changes in the serum levels of thrombosis biomarkers (hsCRP, IL-10 and P-selectin) were comparable between the subcutaneous and continuous infusion groups. Conclusion: Both subcutaneous injection and continuous infusion of heparin as thromboprophylaxis showed same effects on the thrombosis biomarkers. © 2016 Future Medicine Ltd.
PubMed | Tehran University of Medical Sciences and Ahwaz Jondishapour University of Medical science
Type: Journal Article | Journal: Journal of comparative effectiveness research | Year: 2016
Association between thrombosis pathogenesis and inflammatory conditions has been reported. Also inflammatory biomarkers have been proposed for prediction of thrombosis events.Effects of different methods of heparin administration (subcutaneous vs continuous infusion) as thromboprophylaxis on the biomarkers of thrombosis have been evaluated.Serum levels of hsCRP, IL-10 and P-selectin as the biomarkers of thrombosis were measured at baseline, days 3 and 7 during the patients hospitalization period.Changes in the serum levels of thrombosis biomarkers (hsCRP, IL-10 and P-selectin) were comparable between the subcutaneous and continuous infusion groups.Both subcutaneous injection and continuous infusion of heparin as thromboprophylaxis showed same effects on the thrombosis biomarkers.
Sameni H.,Semnan University of Medical Sciences |
Panahi M.,Ahwaz Jondishapour University of Medical science
Cell Journal | Year: 2011
Objective: Diabetic neuropathy is the most common complication of diabetes mellitus affecting the nervous system. In this study, we investigated the in vivo effects of combined administration of 4-methylcatechol (4-MC) and progesterone (P) as a potential therapeutic tool for sciatic nerve function improvement and its role in histomorphological alterations in diabetic neuropathy in rats. Materials and Methods: Male adult rats were divided into 3 groups: sham operated control (CO), untreated diabetic (DM) and diabetic treated with progesterone and 4-methylcatechol (DMP4MC) groups. Diabetes was induced by a single dose injection of 55 mg/kg streptozotocin (STZ). Four weeks after the STZ administration, the DMP4MC group was treated with P and 4-MC for 6 weeks. Then, following anesthesia, the animals' sciatic nerves were removed and processed for light and transmission electron microscopy (TEM) as well as histological evaluation. Results: Diabetic rats showed a statistically significant reduction in motor nerve conduction velocity (MNCV), nerve blood flow (NBF), mean myelinated fiber (MF) diameters and myelin sheath thickness of the sciatic nerve after 10 weeks. In the sciatic nerve of the untreated diabetic group, endoneurial edema and increased number of myelinated fibers with myelin abnormalities such as infolding into the axoplasm, irregularity of fibers and alteration in myelin compaction were also observed. Treatment of diabetic rats with a combination of P and 4-MC significantly increased MNCV and NBF and prevented endoneurial edema and all myelin abnormalities. Conclusion: Our findings indicated that co-administration of P and 4-MC may prevent sciatic nerve dysfunction and histomorphological alterations in experimental diabetic neuropathy.
Karandish M.,Ahwaz Jondishapour University of Medical science |
Naghashpoor M.,Ahwaz Jondishapour University of Medical science
Journal of Biological Sciences | Year: 2010
The aim of this cross-sectional study was to determine the calcium intake pattern among post menopausal women in Ahwaz, Iran. Fifty-three post menopausal women (age 57±9 year) were selected randomly. Calcium intake was estimated with a Food Frequency Questionnaire (FFQ) including fourteen items of the richest food sources of calcium. In order to evaluate calcium intake pattern, the food items divided into three categories, as dairy, grain and vegetable. Mean and standard deviation of total daily dietary calcium intake and from dairy, grain and vegetable groups were 984±354, 629±318, 200+133 and 167±151 mg, respectively. Mean and standard deviation of the daily total calcium contribution of dairy, grain and vegetable groups in calcium intake was 61 ±19, 22 ±16 and 17±14%, respectively. The results of this study suggested that the dietary calcium intake pattern in Ahwazian postmenopausal women is not suitable with regard to high servings of milk and dairy products; because of the effect of this food group (particularly, high fat items) on cardiovascular diseases. © 2010 Asian Network for Scientific Information.
Keikhaei B.,Ahwaz Jondishapour University of Medical science
Pakistan Journal of Medical Sciences | Year: 2010
Objective: To compare the validity of a new index (Hb×RDW×100/ (RBC)2×MCHC) with twelve discriminating functions (DFs) to differentiate iron deficiency anemia (IDA) and beta-thalassemia trait(ß -TT). Methodology: A total of 823 patients (317 IDA and 506 ß -TT) aged 15 to 35- year- old were enrolled in this study. The diagnostic sensitivity, specificity and other validity parameters were calculated to assess the diagnostic reliability of the novel index [Keikhaei index (KI)] vis-a-vis the other published DFs [Mentzer Index (MI), Green & King Index (G&KI),red cell distribution width index (RDWI), England & Fraser Index (E&FI), Bessman and Feinstein index (B&FI), Telmissani et al index (TI), Srivastava and Bevington index (S&BI), Shine and Lal index (S&LI), Ricerca et al index (RI), Ehsani et al index (EI), Sirdah et al index (SI), and Red Blood Cell Count(RBC)] were calculated in all patients. Results: All thirteen DFs didn't have the sensitivity and specificity of 100%. The KI, RDWI, G&KI and E&FI showed the most sensitivity and specificity for both IDA and TT; moreover, the lowest reliable indices belonged to B&FI, S&LI and RI. Conclusion: According to Youden's index (YI), DFs in the order of highest to lowest were KI > G&KI > RDWI > E&FI > RBC> M I> EI > TI > SI > S&BI > RI> S&LI >B&FI.
Nikakhlagh S.,Ahwaz Jondishapour University of Medical science
Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria | Year: 2010
BACKGROUND: Nasal polyposis is the benign protrusion of soft tissue into the nasal cavity, with multifactorial origin. This study is designed to examine the suggested role of IgE and CD4 and CD8 lymphocytes in the pathogenesis of nasalpolyposis. METHODOLOGY: Blood samples were taken from 32 patients with chronic polypoid sinusitis and 32 controls. CD4 and CD8 total lymphocyte count were determined by flow cytometry and the level of serum IgE was measured by ELISA. Nasal discharge samples were also collected for determining IgE level in both patients and controls during surgery. RESULTS: In 68.8% of patients a history of allergy was present. The level of nasal discharge IgE was significantly higher (p < 0.001) in patients compared to controls, but the difference between serum IgE levels was not significant (p > 0.05). CD8 concentration and blood lymphocytes were significantly higher (p < 0.001) in the patients group, while CD4 concentration was significantly lower (p < .OO01) in them. Finally, CD4/CD8 ratio was significantly lower(p < 0. 001) in the patients group. CONCLUSION: This study suggests that a change in the amount of CD4 and CD8 lymphocytes and an increased level of local IgE contribute to nasal polyposis, but the results should be confirmed in more extensive studies including cytokine analyses. Such increasing insights in the pathophysiology of nasal polyposis open perspectives for new pharmacological treatment options, with immunologic factors as potential targets.
PubMed | Ahwaz Jondishapour University of Medical science
Type: Journal Article | Journal: Turkish journal of haematology : official journal of Turkish Society of Haematology | Year: 2016
Iron deficiency anemia (IDA) and - Thalassemia Trait (-TT) are the most common forms of microcytic anemia. This study was conducted to compare the validity of these discrimination indices in differentiating - Thalassemia Trait (-TT) from IDA by calculating their sensitivity, specificity and Youdens index.Totally 323 subjects (173 children and 150 adult) with microcytic anemia were involved in this study. We calculated 10 discrimination indices in all patients with IDA and -TT. We divided the patients into two different groups as younger and older than 10 years.None of indices showed sensitivity and specificity of 100% in the patients older than 11 years, but only Shine and Lal Index showed sensitivity close to 90% and specificity of 100% in the patients younger than 10 years. The most accurate discriminative index for patients younger than 10 years was Shine & Lal and in case of patients older than 11 years it was RDWI. Youdens index for Shine & Lal & RBC Count and for RDWI & RBC Count indices has most diagnostic value for younger and older than 10 years, respectively.None of the indices was completely sensitive and specific in differentiation between -TT and IDA. MCHD mean and median were very close to normal values for both IDA and -TT patients, but in case of MHDL we have found mean and median were significantly higher than normal values in -TT and lower than those in IDA patients. In our study, Youdens index of RBC and S & L were the highest and the most reliable discrimination indices in differentiating -TT from IDA in the patients younger than 10 years and for patients older than 11 years, the most reliable discrimination indices were RBC and RDWI.