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Nikzamir A.,Ahwaz Jondi Shapour University of Medical science | Nikzamir A.,University of Tehran | Rashidi A.,University of Tehran | Esteghamati A.,University of Tehran | And 3 more authors.
Ophthalmic Genetics | Year: 2010

Background: The role of genetic factors in diabetic retinopathy (DR) is unclear. We investigated the relationship between DR and an insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene in Iranian patients with type 2 diabetes without overt nephropathy. Methods: A total of 178 consecutive type 2 diabetic patients with DR (Group A) and 206 type 2 diabetic patients without DR (Group B) were studied. The following variables were determined: age, sex, body mass index, diabetes duration, medications used, history of coronary artery disease and its complications, blood pressure (systolic and diastolic), fasting plasma glucose, hemoglobin A1c, total cholesterol, low- and high-density lipoproteins, triglycerides, plasma creatinine, and 24-h urine albumin excretion. Results: The groups were statistically similar in all variables except diabetes duration (P0.037), ACE activity (P<0.001), and ACE genotype (P0.008). The DD genotype was significantly more common in Group A (32.6% versus 19.2% in Group B; P0.009). In multivariate regression analysis, the ID genotype (compared to the II genotype) was an independent predictor of DR (OR1.831, 95% CI1.0743.124; P0.026). Conclusions: The D allele of the ACE gene is independently associated with DR in Iranian type 2 diabetic patients. © 2010 Informa Healthcare USA, Inc.

Rahimi F.,Tehran University of Medical Sciences | Abdi F.,Tehran University of Medical Sciences | Mafi M.,Tehran University of Medical Sciences | Esfahani M.,Ahwaz Jondi Shapour University of Medical science | Faramarzi N.,Tehran University of Medical Sciences
Asian Journal of Ophthalmology | Year: 2016

A 36-year-old man with his 11-year-old son presented with ocular surface irritation symptoms and blurred vision since early childhood, on exam visual acuity of the man was 5/10(OD), 4/10(OS) and his son was 6/10(OD), 5/10(OS), other exams of these patients were similar: eyelid examination showed absence of meibomian gland orifices, after application of fluorescein dye there was a thin tear film layer and diffuse punctuate epithelial erosions on the cornea, remaining exams were unremarkable. © Asian Journal of Ophthalmology.

Ranjzad F.,Tehran University of Medical Sciences | Mahban A.,Shahid Beheshti University of Medical Sciences | Irani Shemirani A.,Shahid Beheshti University of Medical Sciences | Mahmoudi T.,Shahid Beheshti University of Medical Sciences | And 3 more authors.
Journal of Assisted Reproduction and Genetics | Year: 2011

Purpose: The purpose of this study was to evaluate the associations between polymorphisms in vitamin D receptor (VDR), parathyroid hormone (PTH), calcium sensing receptor (CASR), insulin receptor (INSR), and adiponectin (ADIPOQ) genes and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Methods: Serum levels of LH, FSH, estradiol, testosterone, prolactin, SHBG, glucose, IGF-1, IGFBP-1, calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH) 2 D were measured in 56 women with PCOS. Furthermore, genotyping five, one, one, two, and two polymorphisms of the VDR, PTH, CASR, INSR, and ADIPOQ genes, respectively, were performed. Results: The VDR TaqI "CC" genotype was associated with elevated serum levels of LH (p∈=∈0.011). There were significant associations between decreased levels of SHBG and both VDR BsmI "GG" (p∈=∈0.009) and ADIPOQ BsmI "CC" (p∈=∈0.016) genotypes. Furthermore, patients with CaSR Hin1I "TG" genotype showed higher HoMA-IR (p∈=∈0.008). All these associations remained significant after Bonferroni correction. In addition, phosphorus correlated negatively with estradiol (r∈=∈-0.298, P∈=∈0.026) and positively with glucose (r∈=∈0.287, P∈=∈0.032). Conclusions: These data indicated for the first time that it is possible that the VDR and CASR gene variants through their effects on LH and SHBG levels, and insulin resistance are involved in pathogenesis of PCOS. © 2010 Springer Science+Business Media, LLC.

Ranjzad F.,Shahid Beheshti University of Medical Sciences | Mahmoudi T.,Royan Institute for Stem Cell Biology and Technology | Shemirani A.I.,Shahid Beheshti University of Medical Sciences | Mahban A.,Shahid Beheshti University of Medical Sciences | And 4 more authors.
Molecular Biology Reports | Year: 2012

In this study, we explored whether polymorphisms in insulin receptor (INSR), adiponectin (ADIPOQ), parathyroid hormone (PTH), and vitamin D receptor (VDR) genes are associated with polycystic ovary syndrome (PCOS). A total of 362 subjects, including 181 women with PCOS and 181 controls were enrolled in this case-control study. Two SNPs (rs2059806 and rs1799817) in the INSR gene, two SNPs (rs2241766 and rs1501299) in the ADIPOQ gene, one SNP (rs6256) in the PTH gene, and one SNP (rs757343) in the VDR gene were analyzed using PCR-RFLP method. We observed no significant difference in genotype and allele frequencies between the women with PCOS and controls for the rs2059806, rs1799817, rs1501299, rs6256, and rs757343 polymorphisms either before or after adjustment for confounding factors including age and BMI. However, the ADIPOQ rs2241766 "TT" genotype compared with "TG and GG" genotypes was associated with a 1.93-fold increased risk for PCOS (P = 0.006, OR = 1.93, 95% CI = 1.20-3.11), and the differences remained significant after adjustment for age and BMI (P = 0.039, OR = 1.72, 95% CI = 1.03-2.86). Furthermore, the ADIPOQ rs2241766 "T" allele was significantly overrepresented in women with PCOS than controls (P = 0.006; OR = 1.80, 95% CI = 1.18-2.70), and the difference remained significant after Bonferroni correction. Our findings suggest that the ADIPOQ rs2241766 "TT" genotype is a marker of increased PCOS susceptibility. This study also indicates for the first time that there are no significant association between INSR rs2059806, PTH rs6256, and VDR rs757343 gene polymorphisms and PCOS risk. However, these data remain to be confirmed in larger studies and in other populations. © Springer Science+Business Media B.V. 2011.

Moradzadegan A.,Islamic Azad University at Dezful | Vaisi-Raygani A.,Kermanshah University of Medical Sciences | Nikzamir A.,Ahwaz Jondi Shapour University of Medical science | Rahimi Z.,Kermanshah University of Medical Sciences
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | Year: 2015

Hypothesis: Little is known about the concomitant presence of the angiotensin-converting enzyme (ACE) (rs4646994) D allele and vascular endothelial growth factor(VEGF) (+405G/C; rs2010963) G allele on the susceptibility of coronary artery disease (CAD). Here we examined the hypothesis that ACE-D and VEGF-G alleles act synergistically to increase the severity of CAD in patients with type II diabetes mellitus (T2DM). Materials and methods: The VEGF (rs2010963) and ACE (rs4646994) genotypes were detected by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) and PCR, respectively in 510 T2DM patients undergoing their first coronary angiography. Diabetic patients were classified as T2DM patients with and without CAD (control). Results: The crude odds ratio (OR) for the presence of CAD in ID+DD and D allele carriers were 1.98 (p=0.01) and 1.55 (p=0.001), respectively. Also, adjusted ORs in the presence of normolipidemia and the absence of history of hypertension for the risk of CAD in the either ACE(rs4646994) D allele or VGEF(rs2010963)-G alleles were 2.08 (p=0.004) and 1.75 (p=0.024), respectively. In addition, the concomitant presence of the ACE-D and VEGF-G alleles increased the risk of CAD 2.25-fold (p=0.043). Conclusion: Our results indicated that ACE(rs4646994)-D allele alone and in the presence of VEGF(rs2010963)-G allele can be an important independent risk factor for susceptibility of CAD in T2DM patients even after correcting for conventional risk factors in a population of Iran. © SAGE Publications.

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