Ahvaz Jundishapur University of Medical Sciences

Ahvaz, Iran

Ahvaz Jundishapur University of Medical science is a medical school in Khuzestan Province of Iran.Located in southwestern Iran in the city of Ahvaz, the university was established as a College of Medicine administered by the Shahid Chamran University of Ahvaz in 1955, which itself was a revived reincarnation of the ancient Academy of Gundishapur that existed in the same area in antiquity. The university separated and fell under the Ministry of Health and Medical Education of Iran in 1986.The university has 3 campuses in Ahvaz, Behbahan, and Abadan, and is constituted of 9 Schools, offering doctorate degrees in science and medicine in 27 fields.The university administers 8 public hospitals in the city of Ahvaz, and 20 other hospitals in the surrounding areas, as well as dozens of clinics scattered in the province. Wikipedia.

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Yadollahpour A.,Ahvaz Jundishapur University of Medical Sciences | Rezaee Z.,Ahvaz Jundishapur University of Medical Sciences
Biomedical and Pharmacology Journal | Year: 2014

Electroporatlon Is a highly effective method to Increase permeability of cell membrane by using series of short intense electric pulses. Using this technique, we can Introduce small and large molecules Into cells. The electroporatlon of biological membranes has various applications In molecular biology and medicine. Despite the numerous applications of electroporatlon, the detailed effects of electric pulse on biological membranes as well as exact mechanisms of pore formation In lMng cells are not well understood. Several in-vitro and In-vlvo experimental studies have been conducted to determine the mechanisms of action of electroporatlon in various types of membranes. Because of the small spatial and fast temporal scales of this process, direct observation of electroporatlon is difficult, theoretical models and molecular dynamic simulations have been developed to facilitate the Interpretation of experimental data and the understanding of the mechanisms of action of electroporation. The role of phospholipids In respond to external electric fields, behavIor of water dipoles In the complex electric field landscape of the membrane Interface and reorganization of water dipoles In pore formation process have been proposed In these studies. Pore characteristics such as life time, ion selectlvlty size, kinetics of formation as well as number of pores are significant factors in the proposed mechanism of action. The present study reviews the different mechanisms of action of electroporatlon proposed by different experImental and modeling studies.

Yadollahpour A.,Ahvaz Jundishapur University of Medical Sciences | Jalilifar M.,Ahvaz Jundishapur University of Medical Sciences
Biomedical and Pharmacology Journal | Year: 2014

Epilepsy Is a common neurological disorder affecting more than 1.5 percent worldwide. Twenty percent of epilepsies are drug resistant. Therefore, early detection of prediction of epileptic seizures Is of prime significance to decrease the burdens of the disease. There is strong evidence indicating seizures develop minutes to hours before clinical onset. This change is based on quantitative studies of long term electroencephalographic monitoring (EEG) from patients administered for epilepsy surgery. The possibility of early prediction of seizure has drawn the research interest of diverse fields in medical, engineering, and patent publications. Techniques used to predict seizures include frequency-based methods, statistical analysis of EEG signals, non-linear dynamics (chaos), and intelligent expert systems. Developing efficient methods to predict seizures can lead to designing novel diagnostic and therapeutic techniques for the early diagnosis of seizure attack or preventing the attacks through appropriate modulations of brain activities. The present study reviews the most important and recent methods for seizure prediction. In line with introduction of different efficient seizure predicting approaches, great research interest has been focused on developing new modalities that incorporate these approaches to predict early onset of seizures minutes to hours before they initiate. These modalities will enable experts to develop new interventional treatments such as appropriate responsive electric stimulation applied immediately after the prediction to prevent the seizures or modulating stimulation in controlling the seizure attacks. In the near future, seizures can be predicted in Ume and prevented before clinical and physical indications.

Yadollahpour A.,Ahvaz Jundishapur University of Medical Sciences | Rashidi S.,Ahvaz Jundishapur University of Medical Sciences
Biomedical and Pharmacology Journal | Year: 2014

Electromagnetic fields (EMF8) have been Increasingly used as an alternative or adjunctive treatment option for musculoskeletal disorders (MSDs) like fractures, arthritis and osteoporosis. The electromagnetic based treatments can be divided into four main groups based on their physical characteristics and consequent biological effects: Direct current, capacitive coupling, Inductive coupling (pulsed EMF), and combined magnetic fields. Despite the wide range of treatment modalities and various applications of EMF5 in MSDs, the mechanism of actions of each modality are not yet completely understood. In addition, there was no comprehensive comparative study on different modalities to determine the appropriate technique for each MSD. The present study aims to review the most common EMF based therapeutic methods for MSDs and compare their therapeutic effidency for each disorder. Furthermore, the mechanisms of action of each method are discussed.

News Article | November 28, 2015
Site: www.nanotech-now.com

Home > Press > Iranian Scientists Discover New Catalyst to Remove Pharmaceutical Compounds from Wastewater Abstract: Iranian researchers from Ahvaz Jundishapur University of Medical Sciences produced the laboratorial sample of a nanocatalyst with high efficiency in the elimination of pharmaceutical compounds from wastewater. The nanocatalyst is easily separated from the solution due to its magnetic properties and it can be reused. The presence of pharmaceutical compounds, specially antibiotics, in water is usually a ratio of wastes caused by pharmaceutical industries, personal care products and medications used in hospitals and clinics. The majority of treatment units to refine wastewater are able to eliminate about 60-90% of antibiotics, and the rest directly diffuses into water. Therefore, it is necessary to apply more effective and efficient methods to eliminate the pollutants. The aim of the research was to synthesize a magnetic catalyst to remove tetracycline from aqueous environment. Efforts were also made to select a method by using nanotechnology to decrease the costs and avoid the problems in the separation of catalyst used during the purification process through filtration and centrifugal methods. The synthesized catalyst (active carbon powder/magnetite (PAC/Fe3O4 MNPs)) enjoys highly good capabilities to remove tetracycline. Therefore, it can be used as an effective catalyst to decompose and oxidize pollutants in case it is being mass-produced. In addition, the reaction cost will be reduced due to high efficiency of magnetic catalyst and the ability to be reused and separated quickly. Results showed that high amount of tetracycline and acceptable percentage of all organic carbon existing in the samples was removed due to the process under optimum conditions after four times of catalyst application. Results of the research have been published in RSC Advances, vol. 5, issue 103, 2015, pp. 84718-84727. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Saadati N.,Ahvaz Jundishapur University of Medical Sciences
Global journal of health science | Year: 2013

Menopause is the stage of time in which the menstruation stops following the loss of ovarian activity. The purpose of this study was to find out the effectiveness of gabapentin on hot flashes in postmenopausal women. A randomized controlled trial from Feb 2010 to 2011 was conducted. Sixty postmenopausal women who were referred to obstetrics and gynecology ward of two educational hospitals were recruited and divided into two groups (intervention and control). Intervention group received 300 mg gabapentin three times a day for three months, while control group received placebo. The Intensity and duration of hot flashes in women scored and recorded using visual analog scale. Independent, Paired t-test and chi-square test were used for analyzing data. Intensity of hot flashes in the beginning of research in the intervention group was significantly different with the first, second and third follow-up visit (P<0.05). Also at the end of intervention a significant difference between intervention and control groups were observed regarding the intensity, frequency and duration of hot flashes (P<0.05 and P=0.01 respectively). According to the findings of this study; it appears that the use of gabapentin could decrease the intensity, duration and frequency of hot flashes in postmenopausal women. For postmenopausal women who hormone therapy is contraindicated, gabapentine could be an acceptable alternative.

Tuberculosis is a public health problem worldwide, and new easy to perform diagnostic methods with high accuracy are necessary for optimal control of the disease. Recently, fluorescent silica nanoparticles (FSNP) has attracted immense interest for the detection of pathogenic microorganisms. The aim of this study was to detect Mycobacterium tuberculosis in clinical samples using bioconjugated FSNP compared with microscopic examination, polymerase chain reaction (PCR), nested PCR, and culture as the gold standard. In total, 152 sputum specimens were obtained from patients who were suspected to have pulmonary tuberculosis. All samples were examined by the four techniques described. The assay showed 97.1% sensitivity (95% confidence interval [CI] 91-99.2) and 91.35% specificity (CI 78.3-97.1). Furthermore, assays using variable bacterial concentrations indicated that 100 colony forming units/mL of M. tuberculosis could be detected. There were no differences between the results obtained from two types of mouse monoclonal antibody against Hsp-65 and 16 KDa antigens. We performed this assay in a large number of clinical samples to confirm the diagnostic specificity and sensitivity of the test and can recommend its application for diagnosis of M. tuberculosis. We believe that this method is more convenient for routine diagnosis of M. tuberculosis in sputum and will be more easily applicable in the field, and with sufficient sensitivity.

Nikakhlagh S.,Ahvaz Jundishapur University of Medical Sciences
Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria | Year: 2012

The aim of this study was to evaluate the management of antrochoanal polys (ACPs) with functional endoscopic sinus surgery and review literatures. We retrospectively studied the clinical presentations and operative records of 94 patients with ACPs treated surgically in the period of September 1999 to March 2008 (about 9 years). Age, gender, side, Clinical symptoms, duration of follow up, associated rhinological findings, forms of surgical treatment, postoperative complications and recurrence rate were reviewed. Total records of 94 patients [mean (+/- SD age of 26.5 +/- 12.8 years, 55 males (58.5%) and 39 females (41.5%)] were studied. Postoperative follow-up duration ranged from 8 to 68 months. The most common clinical symptom was nasal obstruction (100%) and Rhinorrhoea (57.4%). The origins and sites of the pedicle in the maxillary sinus were mostly present in medial wall in 32 patients. Recurrence rate in our study was of 5.3% (5 cases) after 10 months postoperatively. For the revision surgery, endoscopic resection was combined with Caldwell-Luc procedure. The antrochoanal polyp happens predominantly in children and young adults of both male and female patients. Endoscopic sinus surgery is an effective, safe and reliable method with major advantage for the treatment of antrochoanal polyps.

BACKGROUND: Pain after knee surgery, if not relieved, it would lead to a more severe and prolonged pain that can delay the patients recovery and rehabilitation. The effect of pain relief by some drugs after intra-articular injection has been shown. This study compared the effect of intra-articular injection of opioids (morphine, pethidine, methadone, and tramadol) on postoperative relieving pain after arthroscopic anterior cruciate ligament (ACL) reconstruction. METHODS: 150 candidate patients for knee arthroscopic ACL reconstruction were randomly enrolled into five groups. At the end of the procedure, all patients in each group received a joint injection solution including 9.5 millimeters bupivacaine with 1:200,000 epinephrine. The remaining 0.5 milliliters of syringe capacity was filled with one of the five solutions listed below: methadone group I: 5 mg methadone, morphine group II: 5 mg morphine, pethidine group III: 37.5 mg pethidine, tramadol group IV: 100 mg Tramadol, and control group V: 0.5 ml normal saline. Afterwards, any drug further administered to the patients based on need was recorded, and the morphine equivalent for all drugs was calculated. Patients need to narcotic drugs during the first twelve hours of hospitalization and pain scores were recorded. After data gathering, they were analyzed by SPSS 16 software with chi-Square, Kruskal-Wallis and ANOVA statistical tests. RESULTS: The highest and the lowest significant pain intensity were seen in placebo and morphine groups, respectively, in the first, second and third 4 hours after surgery. There were significant differences among the groups for need to analgesics. In other words, placebo group needed the highest dosage of analgesics and morphine and methadone groups needed the lowest dosage of analgesics. Morphine and methadone groups had maximum and minimum response to pain, respectively, in the first, second and third 4 hours after surgery. CONCLUSIONS: Administering 5 mg intra-articular morphine after arthroscopic ACL reconstruction is a valuable choice and is recommended to be added to other local anesthetics administrated drugs after this procedure.

Payandeh A.,Ahvaz Jundishapur University of Medical Sciences
Global journal of health science | Year: 2013

Malnutrition in preschool children is a significant problem and has been identified by the World Health Organization (WHO) as the most lethal form of malnutrition, indirectly or directly causes an annual death of at least 5 million children worldwide. The object of this study was to estimated the rate of underweight, stunting and wasting among preschool children in northeast of Iran. A cross sectional population based study was conducted and 70339 children; 35792 males and 34547 females were recruited. The primary outcome variables were; weight, height, age and gender of the children. The sex and age specific rate and overall rate of underweight, stunting, and wasting were calculated. The rate of underweight, stunting, and wasting were 7.5%, 12.5% and 4.4% respectively. There were significant differences in stunting and wasting rate between boys and girls. The overall rate of stunting was significantly higher than the overall rates of underweight and wasting. The rate of malnutrition increased with child's age. In compare to WHO criteria, the rate of malnutrition among this study population was low. According to the higher rate of stunting, the main goal of future research and interventions must be finding the causes of deficiency in height growth and improving it.

Malehi A.S.,Ahvaz Jundishapur University of Medical Sciences
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: The objective of this study was to determine a diagnostic classification scheme using a decision tree based model. Materials and Methods: The study was conducted as a retrospective case-control study in Imam Khomeini hospital in Tehran during 2001 to 2009. Data, including demographic and clinical-pathological characteristics, were uniformly collected from 624 females, 312 of them were referred with positive diagnosis of breast cancer (cases) and 312 healthy women (controls). The decision tree was implemented to develop a diagnostic classification scheme using CART 6.0 Software. The AUC (area under curve), was measured as the overall performance of diagnostic classification of the decision tree. Results: Five variables as main risk factors of breast cancer and six subgroups as high risk were identified. The results indicated that increasing age, low age at menarche, single and divorced statues, irregular menarche pattern and family history of breast cancer are the important diagnostic factors in Iranian breast cancer patients. The sensitivity and specificity of the analysis were 66% and 86.9% respectively. The high AUC (0.82) also showed an excellent classification and diagnostic performance of the model. Conclusions: Decision tree based model appears to be suitable for identifying risk factors and high or low risk subgroups. It can also assists clinicians in making a decision, since it can identify underlying prognostic relationships and understanding the model is very explicit.

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