El Ahram Canadian University

Ahram, Egypt

El Ahram Canadian University

Ahram, Egypt
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Ghaly N.S.,National Research Center of Egypt | Mina S.A.,Helwan University | Younis N.A.H.,El Ahram Canadian University
Journal of Pharmaceutical Sciences and Research | Year: 2016

In the present study screening of the cytotoxic activity of J. communis L. family (Cupressaceae) cultivated in Egypt was performed using MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) in vitro assay against three cancer cell lines, human prostate cancer cells (PC3), human colon cancer cells (HCT 116) and breast cancer cells (MCF7). Both LC50 and LC90 were determined for each cell type using Doxorubicin as positive control, the highest activity with the safest margin of use was recorded for the total methanolic extract against human breast cancer cell line (MCF7). In addition to a phytochemical analysis of the total methanolic extract of the aerial parts which led to the isolation and structure elucidation of two flavonoids, amentoflavone (1) and quercetin-3-o-α-L-rhamnopyranoside (2) separated for the first time from this specie. © 2016, Pharmainfo Publications. All rights reserved.

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