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Zaria, Nigeria

Ahmadu Bello University is the largest university in Nigeria and second largest in Africa, after Cairo University, Egypt. It is in Zaria. It was founded on October 4, 1962 as the University of Northern Nigeria.Ahmadu Bello University operates two main campuses: Samaru and Kongo. The Samaru campus houses the administrative offices, science, social-science, arts and languages, education, engineering, medical science agricultural science and research facilities. The Kongo campus hosts the Faculties of Law and Administration. The Faculty of Administration consists of Accounting, Business Administration, Local Government and Development Studies and Public Administration Departments. Additionally, the university is responsible for a variety of other institutions and programs at other locations.The university is named after the Sardauna of Sokoto, Alhaji Sir Ahmadu Bello, the first premier of Northern Nigeria.The university runs a wide variety of undergraduate and graduate programs . The university has a large medical program with its own A.B.U. Teaching Hospital, one of the largest hospitals in Nigeria. Wikipedia.

Isah M.B.,Umaru Musa YarAdua University | Ibrahim M.A.,Ahmadu Bello University
Parasitology Research | Year: 2014

Oxidative damage is one of the most important pathological consequences of malarial infections. It affects vital organs of the body manifesting in changes such as splenomegaly, hepatomegaly, endothelial and cognitive damages. The currently used antimalarials often leave traces of these damages after therapy, as evident in memory impairment after cerebral malaria. Hence, some research investigations have focused attention on the use of antioxidants, alone or in combination with antimalarials, as a viable therapeutic strategy aimed at alleviating plasmodium-induced oxidative stress and its associated complications. However, the practical application of this approach often yields conflicting outcomes because some antimalarials specifically act via induction of oxidative stress. This article critically reviews most of the studies conducted on the potential role of antioxidant therapy in malarial infections. The most frequently investigated antioxidants are vitamins C and E, N-acetylcystein, folate and desferroxamine. Some of the investigations measured the effects of direct administration of the antioxidants on the plasmodium parasites while others performed an adjunctive therapy with standard antimalarials. The therapeutic application of each of the antioxidants in malaria management depends on the targeted aspect of malarial pathology. It is hoped that this article will provide an informed basis for future research activities on the therapeutic role of antioxidants on malarial pathogenesis. © 2014 Springer-Verlag Berlin Heidelberg. Source

Hassan H.S.,Ahmadu Bello University
African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines | Year: 2012

Crude saponin extracts of five medicinal plants used in the treatment of inflammatory diseases like rheumatoid arthritis, gout and haemorrhoids were screened for anti-inflammatory activity using carrageenan-induced rat paw oedema test. These plants were the whole plant of Schwenkia americana Linn (WSA), the rhizomes of Asparagus africanus Lam (RAA), the leaves of Dichrostachys cinerea Linn (LDC), the stem bark of Ficus iteophylla Miq (BFI) and the leaves of Indigofera pulchra Willd (LIP). A modify traditional method of crude saponins extraction was used to give the following percentage yields: WSA-2.74%, RAA-3.59%, LDC-1.62%, BFI-0.81% and LIP-1.57% respectively. Thin-layer chromatography was used to identify the type of saponins present in the extracts. The acute toxicity study of the crude saponin extracts in mice gave the following intraperitoneal LD50: WSA-471.2mg/kg, RAA- 1264.9mg/kg, LDC-1264.9 mg/kg, BFI-118.3mg/kg and LIP-1264.9 mg/kg respectively. The anti-inflammatory study of the extracts showed statistically significant (P<0.05) decreases in the rat paw-oedema as compared to the control. The percentage inhibitions of the extracts after four hours were as follow: WSA-61%, RAA-55%, LDC-72%, BFI-66% and LIP-40% respectively. These values were found to be comparable to that of ketoprofen-63%. The study showed that the anti-inflammatory properties attributable to these plants may be due to their saponins contents. Source

Quantum chemical parameters, namely energy of the highest occupied molecular orbital, energy of the lowest unoccupied molecular orbital, energy gap, dipole moment, total energy, total electronic energy, core-core repulsion, ionisation potential, cosmo area, cosmo volume and other quantum descriptors [calculated from PM6, PM3, AM1, RM1 and modified neglect of diatomic overlap (MNDO) Hamiltonians], have been used to predict the corrosion inhibition potential of asparagine, aspartic acid, glutamine and glutamic acid. The results obtained indicate that the trend for the variation of the inhibition efficiencies of the compound is in the order: glutamine > asparagine > aspartic acid > glutamic acid. There is a strong agreement between some quantum chemical parameters and the experimental inhibition efficiencies. In order to establish the sites for electrophilic and nucleophilic attacks, condensed Fukui function, condensed softness and relative nucleophilicity/ electrophilicity were considered. The results reveal that the sites for nucleophilic attacks in aspartic acid and glutamine are at the nitrogen atom (N5) but at the carbon atom (C3) for asparagine and glutamic acid. The sites for electrophilic attacks are at the oxygen atom (O9, for aspartic acid), carbon atom (C6, for asparagine), oxygen atom (O10, for glutamic acid) and nitrogen atom (N9, for glutamine). © 2010 Taylor & Francis. Source

Atawodi S.,Ahmadu Bello University
Infectious Agents and Cancer | Year: 2011

Dietary polyphenols are antioxidants that can scavenge biological free radicals, and chemoprevent diseases with biological oxidation as their main etiological factor. In this paper, we review our laboratory data vis - vis available literature on prostate cancer chemopreventive substances in Nigerian foodstuffs. Dacryodes edulis fruit, Moringa oleifera and Syzygium aromaticum contained prostate active polyphenols like ellagic acid, gallate, methylgallate, catechol, kaempferol quercetin and their derivatives. Also Canarium schweinfurthii Engl oil contained ten phenolic compounds and lignans, namely; catechol, p-hydroxybenzaldehyde, dihydroxyphenylacetic acid, tyrosol, p-hydroxybenzoic acid, dihydroxybenzoic acid, vanillic acid, phloretic acid, pinoresinol, secoisolariciresinol. In addition, tomatoes (Lycopersicon esculentum Mill) which contains the powerful antioxidant and anti-prostate cancer agent, lycopene; cabbage (Brassica oleracea) containing indole-3-carbinol; citrus fruits containing pectin; Soursop (Annona muricata) containing annonaceous acetogenins; soya beans (Glycine max) containing isoflavones; chilli pepper (Capsicum annuum) containing capsaicin, and green tea (Camellia sinensis) containing (-) epigallocatechin gallate (EGCG), (-) epicatechin, (-) epicatechin-3-gallate and (-) epigallocatechin -3-gallate which are widely reported to posses prostate cancer chemopreventive compounds are also grown in Nigeria and other African countries. Thus, the high incidence of prostate cancer among males of African extraction can be dramatically reduced, and the age of onset drastically increased, if the population at risk consumes the right kinds of foods in the right proportion, beginning early in life, especially as prostate cancer has a latency period of about 50 years. © 2011 Atawodi; licensee BioMed Central Ltd. Source

Singh J.,Ahmadu Bello University
Astrophysics and Space Science | Year: 2013

This study explores the effects of small perturbations in the Coriolis and centrifugal forces, radiation pressures and triaxiality of the two stars (primaries) on the position and stability of an infinitesimal mass (third body) in the framework of the planar circular restricted three-body problem (R3BP). it is observed that the positions of the usual five (three collinear and two triangular) equilibrium points are affected by the radiation, triaxiality and a small perturbation in the centrifugal force, but are unaffected by that of the Coriolis force. The collinear points are found to remain unstable, while the triangular points are seen to be stable for 0<μ<μc and unstable for μc ≤ μ ≤ 1/2, where μc is the critical mass ratio influenced by the small perturbations in the Coriolis and centrifugal forces, radiation and triaxiality. It is also noticed that the former one and all the latter three posses stabilizing and destabilizing behavior respectively. Therefore, the overall effect is that the size of the region of stability decreases with increase in the values of the parameters involved. © 2013 Springer Science+Business Media Dordrecht. Source

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