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Sofia, Bulgaria

Iantcheva A.,AgroBioInstitute | Mysore K.S.,Samuel Roberts Noble Foundation | Ratet P.,French National Center for Scientific Research
International Journal of Developmental Biology | Year: 2013

Legume plants are important in agriculture because they represent an important source of protein for human and animal consumption. This high protein content results from their capacity to use atmospheric nitrogen for their nutrition as a consequence of their symbiotic interaction with rhizobia. Understanding this interaction at the molecular level is a prerequisite for its better use in agriculture and for the long term objective of its transfer to other crops. Agrobacterium-mediated transformation is a tool of choice for studying this interaction and for unraveling the function of the different genes discovered through classical genetic approaches. However, legume plants are often recalcitrant to regeneration and transformation. This paper describes the technology developments (regeneration, transformation, insertion mutagenesis) related to Agrobacterium transformations that were established in the legume plants, as well as different examples of the technology developments or gene discoveries resulting from these studies. © 2013 UBC Press. Source

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2012.2.4-05 | Award Amount: 1.21M | Year: 2012

While there are many European scientific activities for each of the items related to either animal health or the occurrence of GM ingredients in animal feed, the proposed MARLON project will be unique in bringing these widely different fields of scientific expertise together for the cross-disciplinary task of developing an epidemiological model for the case-specific monitoring of potential health impacts of GM animal feeds in livestock. More specifically, the proposed MARLON project will create an inventory of which epidemiological and monitoring initiatives exist, both within and outside the EU, which could provide useful data for the purpose of monitoring for health impacts of animal feeds, in particular those containing GM ingredients, on livestock animals. It will also collate, in a systematized manner, information on the factors that have to be considered when developing an epidemiological model specifically geared towards this purpose. These factors include 1) the possibility to determine the exposure of animals to GM feed ingredients, 2) the health indicators that have to be considered for particular cases of health impacts identified during pre-market risk assessment of the GMOs, 3) the characteristics of the animal feed and livestock production chains. The project also will develop an epidemiological model specifically geared towards establishing links between measured health effects in livestock and their intake of GM ingredients from animal feed. As previously stated, there are many activities in the EU focusing on the specific items that together constitute the cross-disciplinary research within the proposed MARLON project, but so far none of them has done this in its totality for the specific purpose of linking health impacts in livestock to GM feed consumption. The proposed MARLON project is to take stock of these initiatives and assess the applicability of the data collected and/or generated by them for the purpose of case-specific monitoring.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2012.3.5-04 | Award Amount: 7.76M | Year: 2012

The project GRACE will a) elaborate and sustainably implement a transparent framework for the review of GMOs or GM food and feed effects on environment, socio-economics and health and b) reconsider the design, execution and interpretation of results of animal feeding trials as well as in vitro studies for assessing the safety of GM food and feed. The framework will create high quality reviewing processes for different fields of GMO impact assessment and address the need for a well documented, transparent and sustainable representation of these reviewing processes. This will provide valuable and accessible information addressing the main issues associated with GMOs and enabling risk assessors, managers, scientists and the general public to reiterate and update their evaluations and conclusions on GMOs. It will adapt recently elaborated methodologies for (systematic) reviewing of the risk assessment information of GMOs and derived food and feed. The quality assessment for all reviewed papers and studies as well as the reviews conducted by the consortium, will be referenced by an open access database and one-stop-shop for data and information relevant to GMO risk assessment. Animal feeding trials and in vitro studies will clarify and compare the scientific added value of 90day feeding trials with whole foods with advanced state-of-the-art analytical, in vitro and in-silico tools. Suitable animal GMO-feeding models will be investigated, that are based on European (EFSA) and international guidance, and the project will provide guidance for relevant, alternative in vitro cell-based approaches for specific topics within the overall food and feed safety assessment. Available standard or scientifically approved protocols form the basis of the investigations also in the case of the analytical, in-vitro and second in-silico approaches. GRACE will provide guidance for the use and improvement of existing and suggested assessment tools in the field of food and feed safety.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2011.3.5-01 | Award Amount: 7.78M | Year: 2011

The project aims at 1 providing baseline data on biodiversity in agro-ecosystems in the EU, 2 translating regional protection goals in measurable assessment endpoints, 3 defining lists of suitable bioindicators for various European regions, 4 improving knowledge on potential long term environmental effects of genetically modified plants (GMPs), 5 testing the efficacy of the EFSA Guidance Document (GD) for the Environmental Risk Assessment (ERA) of GMPs, 6 exploring new strategies for post market monitoring, 7 estimating the compatibility of GMPs with the Integrated Pest Management (IPM) principles implemented in the EU, 8 providing a systematic analysis of economical aspects of GMPs cultivation in the EU, and 9 setting a training and communication plan addressing public concerns about GMPs. The consortium includes 22 partners (Research institutes, Universities, State Agencies and SMEs) located in 15 EU countries and. An ICPC country (Argentina) will contribute in validating the monitoring methodology in areas where GM crops are cultivated on larger scales. A cornerstone is the application of the EFSA ERA GD, which is the basis for the update of the regulatory process of GMPs in the EU. The GD has provided ecologically sound principles for ERA, triggering the need of practically testing them. Partners of the consortium participated to the preparation of GD and 3 of them are senior authors of relevant chapters. The scientific activities will consist of case studies of maize and potato, the two GM crops currently approved for cultivation in the EU, and surveys in non-GM agro-ecosystems. The final outcome will include a network of EU representative sites for pre-market risk assessment and long-term monitoring studies, a set of standardised testing methods and a geographical information system integrating relevant datasets, protocols and tools to help EU decision-makers. To be implemented in 4 years, the project estimated costs are 7779852.15 , requested grant 5997963 .

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: KBBE-2008-1-4-07 | Award Amount: 1.17M | Year: 2009

PEGASUS aims to provide policy support regarding the development, implementation and commercialisation of GM animals, and derivative foods. The results will contribute to the FP7 KBBE by integrating existing social, (including existing public perception) environmental and economic knowledge regarding GM animals. The use of GM in farmed animals (aquatic and terrestrial) will be reviewed. A foresight exercise will be conducted to predict future developments. Two case studies (1 aquatic, 1 terrestrial) will be applied to identify the pros and cons of GM animals from the perspectives of the production chain (economics, agri-food sector) and the life sciences (human and animal health, environmental impact, animal welfare, sustainable production). Ethical and policy concerns will be refined through application of combined ethical matrix and policy workshops involving EU and non-EU stakeholders. The case studies will be used to demonstrate best practice in public engagement in the policy process. The activities will provide European policy support regarding GM animals and the foods derived from them, taking into account public perceptions, the competitiveness of EU animal production, and risk-benefit assessments linked with human and animal health, environmental impact, and sustainable production. A final stakeholder dissemination workshop will disseminate the results to the EU policy community.

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