Mancini A.,University of L'Aquila |
Serrano-Diaz J.,Agricultural Chemistry |
Nava E.,University of Castilla - La Mancha |
D'Alessandro A.M.,University of L'Aquila |
And 3 more authors.
Journal of Vascular Research | Year: 2014
Background: Hypertension is associated with endothelial dysfunction characterized by decreased vasorelaxation. Crocetin, a bioactive compound of saffron, exhibits favorable cardiovascular properties. We analyze the vasomodulatory effects of crocetin in hypertension. Methods: Myographical experiments were performed to compare the relaxation induced by acetylcholine (ACH) on aortic rings from normotensive (Wistar) and hypertensive (SHR) rats, incubated with or without crocetin or saffron extract and L-NAME or indomethacin. Extracts were also assayed in deendothelialized rings. UV-vis spectrophotometry and HPLC-DAD were used to characterize and quantify the saffron used. Results: Crocetin enhanced the ACH relaxations in aorta from hypertensive (strongly) and normotensive rats (weakly). Saffron extract did not modify this. Crocetin plus L-NAME abolished the relaxant response in SHR but not in Wistar aorta. Crocetin plus indomethacin did not modify the indomethacin response in either SHR or Wistar aorta. Crocetin in rubbed segments did not modify the ACH responses. In contrast, saffron increased this response in rubbed segments from SHR but not Wistar rats. Conclusion: Crocetin exerts healthy vasomodulatory effects in hypertension, strongly improving endothelium-dependent ACH relaxations via endothelial nitric oxide but not the cyclooxygenase pathway. This work proposes that crocetin supplements are a possible complement in the therapy of hypertension. © 2014 S. Karger AG, Basel.
Vikas S.,Agricultural Chemistry |
Sharma K.N.,Agricultural Chemistry
Communications in Soil Science and Plant Analysis | Year: 2011
Potassium (K) release and kinetics were studied in soils of north western India varying in soil properties. Mathematical equations were tested for their applicability to describe K release in the alluvial soils. The major portion of total K was released within 1 h of the reaction. The initial rapid K release was followed by a slower rate of K release. The linear equation adequately described the K release kinetics. The next best fit to satisfactorily describe the reaction rates of K release was the first order equation. There existed two separate first order equations indicating different rates of K release. Soils having higher native potassium and clay released higher amounts of K and at a faster rate. However, the first order equation showed that the faster rate of reaction might be inhibited by higher amounts of clay, probably because of the restrictive properties of illites. © Taylor & Francis Group, LLC.