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College Park, GA, United States

Agnes Scott College is a private liberal arts college in downtown Decatur, Georgia.The college was founded in 1889 as Decatur Female Seminary by Presbyterian minister Frank H. Gaines. In 1890, the name was changed to Agnes Scott Institute to honor the mother of the college's primary benefactor, Col. George Washington Scott. The name was changed again to Agnes Scott College in 1906, and remains today a women's college.Agnes Scott currently enrolls 914 students. In 2006, the student to faculty ratio was 10:1. Eighty-seven percent of the faculty are full-time, and 100% of the tenure-track faculty hold terminal degrees.The college offers 30 majors and 25 minors and is affiliated with numerous institutions, including Georgia Institute of Technology, Emory University School of Nursing, and Washington University. Students who graduate from Agnes Scott receive a Bachelor of Arts degree.Agnes Scott is affiliated with the Presbyterian Church and is considered one of the Seven Sisters of the South. The current mission of the college, adopted in 2002, states: Agnes Scott College educates women to think deeply, live honorably and engage the intellectual and social challenges of their times. Wikipedia.

To fully understand the roles proteins play in cellular processes, students need to grasp complex ideas about protein structure, folding, and stability. Our current understanding of these topics is based on mathematical models and experimental data. However, protein structure, folding, and stability are often introduced as descriptive, qualitative phenomena in undergraduate classes. In the process of learning about these topics, students often form incorrect ideas. For example, by learning about protein folding in the context of protein synthesis, students may come to an incorrect conclusion that once synthesized on the ribosome, a protein spends its entire cellular life time in its fully folded native conformation. This is clearly not true; proteins are dynamic structures that undergo both local fluctuations and global unfolding events. To prevent and address such misconceptions, basic concepts of protein science can be introduced in the context of simple mathematical models and hands-on explorations of publicly available data sets. Ten common misconceptions about proteins are presented, along with suggestions for using equations, models, sequence, structure, and thermodynamic data to help students gain a deeper understanding of basic concepts relating to protein structure, folding, and stability. © 2010 The American Society for Cell Biology. Source

Hopkins W.D.,Agnes Scott College | Hopkins W.D.,Yerkes National Primate Research Center | Russell J.L.,Yerkes National Primate Research Center | Schaeffer J.A.,Yerkes National Primate Research Center
Philosophical Transactions of the Royal Society B: Biological Sciences | Year: 2012

It has been hypothesized that neurological adaptations associated with evolutionary selection for throwing may have served as a precursor for the emergence of language and speech in early hominins. Although there are reports of individual differences in aimed throwing in wild and captive apes, to date there has not been a single study that has examined the potential neuroanatomical correlates of this very unique tool-use behaviour in non-human primates. In this study, we examined whether differences in the ratio of white (WM) to grey matter (GM) were evident in the homologue to Broca's area as well as the motor-hand area of the precentral gyrus (termed the KNOB) in chimpanzees that reliably throw compared with those that do not. We found that the proportion of WM in Broca's homologue and the KNOB was significantly higher in subjects that reliably throw compared with those that do not. We further found that asymmetries in WM within both brain regions were larger in the hemisphere contralateral to the chimpanzee's preferred throwing hand. We also found that chimpanzees that reliably throw show significantly better communication abilities than chimpanzees that do not. These results suggest that chimpanzees that have learned to throw have developed greater cortical connectivity between primary motor cortex and the Broca's area homologue. It is suggested that during hominin evolution, after the split between the lines leading to chimpanzees and humans, there was intense selection on increased motor skills associated with throwing and that this potentially formed the foundation for left hemisphere specialization associated with language and speech found in modern humans. © 2011 The Royal Society. Source

Correa N.M.,National University of Rio Cuarto | Silber J.J.,National University of Rio Cuarto | Riter R.E.,Agnes Scott College | Levinger N.E.,Colorado State University
Chemical Reviews | Year: 2012

The self-assembly of amphiphiles in the absence of water is studied. The assembly of amphiphiles into microemulsions and reverse micelles in nonpolar solvents while sequestering a polar nonaqueous core is discussed. Fletcher et al. used dynamic light scattering (DLS) and viscosimetry to study thermodynamically stable AOT stabilized dispersions of GY in n-heptane. Sarkar and co-workers have probed GY/AOT/isooctane reverse micelles through steady-state and time-resolved fluorescence spectroscopy of two solvatochromic dyes, coumarin 480 and coumarin 490. Martino and Kaler reported the effect on microemulsion phase behavior and microstructure occurring when replacing water with PG, GY, and their mixtures in systems made with the nonionic surfactants pentaethylene glycol mono-n-decyl ether (C10E5). Mehta et al. have explored phase diagrams for several nonaqueous polar solvents in AOT/hexane. Source

Blanchard K.,Emory University | Robic S.,Agnes Scott College | Matsumura I.,Emory University
Applied Microbiology and Biotechnology | Year: 2014

Metabolic engineers develop inexpensive enantioselective syntheses of high-value compounds, but their designs are sometimes confounded by the misfolding of heterologously expressed proteins. Geobacillus stearothermophilus NUB3621 is a readily transformable facultative thermophile. It could be used to express and properly fold proteins derived from its many mesophilic or thermophilic Bacillaceae relatives or to direct the evolution of thermophilic variants of mesophilic proteins. Moreover, its capacity for high-temperature growth should accelerate chemical transformation rates in accordance with the Arrhenius equation and reduce the risks of microbial contamination. Its tendency to sporulate in response to nutrient depletion lowers the costs of storage and transportation. Here, we present a draft genome sequence of G. stearothermophilus NUB3621 and describe inducible and constitutive expression plasmids that function in this organism. These tools will help us and others to exploit the natural advantages of this system for metabolic engineering applications. © 2014 Springer-Verlag. Source

Meguerditchian A.,Research Center in the Psychology of Cognition | Meguerditchian A.,Yerkes National Primate Research Center | Vauclair J.,Research Center in the Psychology of Cognition | Hopkins W.D.,Yerkes National Primate Research Center | Hopkins W.D.,Agnes Scott College
Cortex | Year: 2010

Whether precursors of the left-lateralization for human language can be found in the vocal and gestural communication systems of nonhuman primates remains a topic of intense research, particularly within theoretical discussions of the evolutionary origins of language. Although previous studies in chimpanzees have reported evidence of right-handedness for inter-species food-beg gestures produced exclusively toward humans, some might question the generality of these results to intra-species communicative signals. To address this issue, we recorded hand use in 70 captive chimpanzees for species-typical signals, that could be directed either toward conspecifics or humans. We found evidence of a predominance of right-handedness for species-typical gestures in captive chimpanzees when directed to both humans and conspecifics. Hand preferences during intra-species communication were significantly and positively correlated with gestures directed toward humans. By contrast, hand preferences for gestures did not significantly correlate with hand use for a non-communicative self-directed action. The collective results suggest (a) that evidence of predominance of right-handedness for human-directed gestures communication is not specific to this context and (b) the existence of a specific communicative system involving gestures constitutes an ideal prerequisite for the cerebral substrates of human language and its typical left-lateralization. © 2009 Elsevier Srl. All rights reserved. Source

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