Cambridge, MA, United States
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Patent
Agios Pharmaceuticals | Date: 2017-04-07

Provided are compounds of formula (I), wherein X, Y, Z, W, V, R^(2), R^(3 )and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.


Patent
Agios Pharmaceuticals | Date: 2017-08-09

Provided are compounds useful for treating cancer and methods of treating cancer, for example an advanced solid tumor, such as a glioma, or angioimmunoblastic T-cell lymphoma (AITL).


Patent
Agios Pharmaceuticals | Date: 2016-11-09

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.


Patent
Agios Pharmaceuticals | Date: 2016-08-16

Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).


Patent
Agios Pharmaceuticals | Date: 2016-10-28

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.


Patent
Agios Pharmaceuticals | Date: 2016-08-04

Provided are compounds useful for treating cancer and methods of making the compounds and intermediates described herein.


Patent
Agios Pharmaceuticals | Date: 2017-01-18

Provided are compounds and pharmaceutical compositions useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound or pharmaceutical composition described herein.


Patent
Agios Pharmaceuticals | Date: 2017-01-18

Provided are compounds and pharmaceutical compositions useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound or pharmaceutical composition described herein.


Patent
Agios Pharmaceuticals | Date: 2017-01-23

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.


Patent
Agios Pharmaceuticals | Date: 2017-01-25

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

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