Santa Clara, CA, United States

Agilent Technologies

www.agilent.com
Santa Clara, CA, United States

Agilent Technologies, or Agilent, is an American company that designs and manufactures measurement instruments and equipment for life science, medical diagnostics, and chemistry applications.Agilent's predecessor company was Hewlett-Packard , founded in 1939 to make electronic test equipment. In 1999, HP spun-off their test and measurement division as Agilent. The resulting IPO of Agilent stock may have been the largest in the history of Silicon Valley at the time. In 2014, Agilent spun-off its electronics instruments division into Keysight Technologies.Agilent maintains a central research and development group, Agilent Laboratories, that conducts the company's research in such areas as microelectromechanical systems, nanotechnology, and life science. This centralized group is based on the original Hewlett-Packard Lab's design and was formed by dividing the original HP Labs group into two when Agilent was carved out of HP in 1999. Wikipedia.

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A secondary stage sample separation device (90) for separating at least a portion of a fluidic sample, wherein the secondary stage sample separation device (90) comprises a fluidic interface (89) configured for forming a fluidic coupling between a primary stage sample separation device (10) and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device (10) is fluidically suppliable to the secondary stage sample separation device (90) via the fluidic interface (89) for further separation, and a pressure reduction mechanism (44) configured for reducing pressure at the fluidic interface (89) at least in the event of an overpressure or of an excessive pressure increase.


Patent
Agilent Technologies | Date: 2017-02-22

Provided is an emulsion comprising: (a) droplets that contain a single polymeric compound or a pre-defined mixture thereof, and (b) an immiscible liquid, wherein: (i) each of the droplets comprises multiple molecules of the compound(s) contained therein; and the droplets do not contain monomeric precursors for the polymeric compound. A method for making the emulsion is also provided.


Patent
Agilent Technologies | Date: 2017-02-01

A light source (11, 30, 40) having first and second wire-grid polarizers (63, 64) and a laser (31, 71) that emits a beam of linearly polarized light that is characterized by a propagation direction is disclosed. The first wire-grid polarization filter (63) is characterized by a first linear polarization pass direction and a first actuator (65) for causing the first linear polarization pass direction to rotate relative to the beam of linearly polarized light. The second wire-grid polarization filter (64) is characterized by a second linear polarization pass direction and a second actuator for causing the second linear polarization pass direction to rotate relative to the beam of linearly polarized light. A controller (29) sets the first and second linear polarization pass directions to provide linearly polarized light having a specified polarization direction.


Patent
Agilent Technologies | Date: 2017-03-29

An implementation of an interlock system (100) disclosed herein provides an interlock system for remotely tracking and controlling usage of a number of equipment (140-144). The interlock system disclosed herein includes an interlock module (130-138) communicatively connected to the equipment (140-144) and is configured to control the status and monitor usage of such equipment. The interlock system (100) further includes a web-based platform (102) including a rule-based engine (108) controlling usage of the equipment based in part on the status and usage of the equipment.


Patent
Agilent Technologies | Date: 2017-04-05

Methods of analyte derivatization and soft ionization are provided. The methods include contacting a sample including an analyte with a derivatization agent to produce a modified analyte including a pseudo-molecular analyte group and a leaving group connected via a fragmentable bond; and selectively breaking the fragmentable bond under soft ionization conditions to produce a predominant first fragmentation product including the pseudo-molecular analyte group and a second fragmentation product including the leaving group. The method may further include analyzing the first and second fragmentation products in a mass spectrometer to identify an ion corresponding to the pseudoanolecular analyte group. Also provided are methods for detecting analytes using gas chromatography-mass spectroscopy (GC-MS). These methods find use in a variety of applications in which mass spectroscopic analysis of samples is desired.


Patent
Agilent Technologies | Date: 2017-01-04

A method and apparatus for obtaining reference samples, i.e. measuring reference targets (62) on a reference stage (61) during the generation of a mid-infrared (MIR) image without requiring that a sample specimen (16), being placed on a specimen stage (57) and imaged, be removed is disclosed. A tunable MIR laser (11) generates a light beam (18) that is focused onto the sample specimen on the specimen stage that moves the specimen in a first direction (33). An optical assembly includes a scanning assembly (31) having a focusing lens (55) and a mirror (56) that moves in a second direction (32), different from the first direction, relative to the specimen stage. A light detector (13) measures an intensity of light leaving the point on the specimen. A controller (39) forms an image from the measured intensity. The reference stage (61) is positioned such that the scanning assembly moves over the reference stage in response to a command so that the controller can also make a reference measurement.


A pump (20) for pumping fluid, wherein the pump (20)comprises a working chamber (200), a piston assembly (202) configured for reciprocating within the working chamber (200) to thereby displace fluid, a piston actuator (204) being rigidly assembled with the piston assembly (202) at least in a working mode of the pump (20) to thereby transmit drive energy to the piston assembly (202) to reciprocate along a common rigid axis (206) of the piston-actuator-assembly, and a bearing arrangement (208, 210) bearing the piston assembly (202) and the piston actuator (204) in the pump (20) so that the piston-actuator-assembly provided by the piston assembly (202) and the piston actuator (204)is capable of performing a pendulum-type compensation motion around a pendulum point (212) at the piston actuator (204) on the common rigid axis (206). Figure2for publication


Patent
Agilent Technologies | Date: 2017-04-19

Provided herein, among other things, is a method comprising: (a) obtaining a mixture of multiple sets of oligonucleotides, wherein the oligonucleotides within each set each comprise a terminal indexer sequence can be assembled to produce a synthon; and (b) hybridizing the oligonucleotide mixture to an array, thereby spatially-separating the different sets of oligonucleotides from one another. Other embodiments are also provided.


Patent
Agilent Technologies | Date: 2017-04-19

The present disclosure provides a unique methodology and protecting groups that enable synthesis of oligonucleotides having Z nucleotide in an easy, clean and site-specific fashion with high yield. In particular, the method causes little to no damage to oligonucleotide product and does not modify the Z nucleotide itself. The invention provides a viable protection strategy for efficient synthesis of long oligonucleotides with Z nucleotide incorporated therein.


An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, first and second portions of the second mobile phase component flowing through third and fourth branches, respectively. The injection unit receives a combined stream of the first portions of the first and second mobile phase components provided via the first and third branches, respectively, and to injects the sample into the combined stream to form a sample-containing stream. The sample-containing stream is subsequently combined with the second portions of the first and second mobile phase components provided via the second and fourth branches, respectively, to form a diluted sample-containing stream, which flows to the separation unit for separating sample constituents.

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