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Hibi T.,Keio University | Cherqui D.,Hepatobiliary Center | Geller D.A.,University of Pittsburgh | Itano O.,Keio University | And 2 more authors.
Surgical Endoscopy and Other Interventional Techniques | Year: 2016

Background: Laparoscopic liver resection (LLR) has undergone widespread dissemination after the first international consensus conference in 2008, and specialized centers continue to report remarkable achievements. However, little is known about the global adoption of LLR. This study aimed to illuminate geographical variances in the indications and technical aspects of LLR and to delineate the evolution of this approach worldwide. Methods: In advance of the Second International Consensus Conference in Morioka, Japan, a web-based, anonymous questionnaire comprising 46 questions, named the International Survey on Technical Aspects of Laparoscopic Liver Resection study, was sent via e-mail to the members of regional and International Hepato-Pancreato-Biliary Association offices. The results of the 13 questions concerning the global diffusion of LLR have been reported previously. Responses to the remaining 33 questions that corresponded to indications and surgical techniques used in LLR were collected and analyzed. Results: Survey responses were received from 412 LLR surgeons in 42 countries on five continents. The majority of surgeons in North America had no restrictions on the maximum size or number of tumors to be resected laparoscopically. Likewise, >50 % of surgeons in East Asia and North America performed LLR for the postero-superior ‘difficult’ segments. Major resection was performed in 40 to >60 % of centers in North America, Europe, and East Asia. Donor hepatectomy was performed only in specialized centers. More than 75 % of respondents had adopted a pure laparoscopic approach. A flexible laparoscope was most commonly used in East Asia. Most surgeons used pneumoperitoneal pressure at around 9–16 mmHg. Other techniques and devices were used at the discretion of each surgeon. Conclusions: Indications for LLR continue to expand with some regional diversity. Surgical approaches and devices used in LLR are a matter of preference and availability, as in open liver resection. © 2015, Springer Science+Business Media New York.


Cleary S.P.,University of Toronto | Han H.-S.,Seoul National University | Yamamoto M.,Tokyo Medical University | Wakabayashi G.,Ageo Central General Hospital | Asbun H.J.,Mayo Clinic Florida
Surgical Endoscopy and Other Interventional Techniques | Year: 2016

Background: The techniques of laparoscopic liver resection (LLR) have developed rapidly in selected centers, while global adoption of this approach has been cautious. The costs of LLR compared to open resection (OLR) are considered an important metric in evaluating this approach and may be a barrier to adoption in some centers. Methods: To formulate a consensus statement using the Zurich-Danish consensus model to the question of “What are the comparative outcomes of cost for LLR and OLR, minor and major?” a systematic search of the literature was conducted. Results were presented to the jury in September 2014 and updated in August 30, 2015. Adjustments for currency conversions and inflation were not performed due to limitations in available data. Results: Thirty-four studies were reviewed, and 11 relevant papers were selected for inclusion. No randomized control studies were found. Five studies were case-matched comparisons, while the remaining studies were retrospective reviews. The number of patients in each study ranged from 28 to 74, and the cumulative number of patients was 643 comparing 350 OLR to 293 LLR. Overall median hospital stay was lower for LLR at 4.6 versus 7.4 days. This remained valid when only the case-matched studies were analyzed, 4.6 (n = 178) versus 6.6 days (n = 266). The median overall total costs were 16.3 % lower (range 0 to −22 %) for LLR compared to OLR. This remained valid in the subgroup analysis of the case-matched studies, with a median 17.4 % lower costs for the LLR. Median OR costs were 3 % higher for LLR (range −9 to 40 %) but 32.9 % lower for hospital ward costs (range 0 to −60 %) when compared to OLR. Conclusions: Currently, the published literature indicates that overall hospital costs are less for LLR when compared to OLR (Level of evidence 3a and 3b). This evidence is strongest for minor hepatic resections. The decreased cost is based on savings in hospital ward costs and likely related to a significantly shorter hospital stay for LLR. © 2016 Springer Science+Business Media New York


Kinoshita T.,Toho University | Kanehira E.,Ageo Central General Hospital | Matsuda M.,Nihon University | Okazumi S.,Toho University | Katoh R.,Toho University
Surgical Endoscopy and Other Interventional Techniques | Year: 2010

Background Laparoscopy-assisted distal gastrectomy (LADG) for stomach cancer is increasingly performed in Japan and Korea. However, the procedure still is considered to be complicated, and the optimal education system for trainees has not been established to date. Methods The authors organized a 1-day professional training course termed the LADG Basic Lab Course for LADG beginners.The participantswere required to apply as a teamof two surgeons and two operating nurses. The training course consisted of lectures and a live porcine lab emphasizing use of the ultrasonically activated device and the flexible laparoscope as well as team cooperation. The quality and effectiveness of the course were evaluated 6-10 months (mean, 8.2 ± 2.2 months) after the course using a survey form sent to a representative surgeon of each institution. Results From May 2007 to July 2008, a total of 80 colleagues (47 surgeons and 33 nurses) from 20 different centers in Japan participated in the training course. These surgeons represented 12.4 ± 6.2 postgraduate years of education and had performed 2.7 ± 4.9 LADGs before taking the course. In the follow-up evaluation, 12 institutions (60%) completed the survey forms. The mean operation time was reduced for eight respondents (66.7%). The number of LADGs performed per month increased in 50% of the respondents' institutions. The degree of lymph node dissection in LADG was extended for 66.7% of the respondents. The respondents answered that 100% of the first operators showed improvement in skills, as did 59.5% of the scope operators and 59.5% of the nurses. Conclusions The training course was an effective means of introducing LADG to each institution. Training courses emphasizing explanations of key devices and teamwork may be effective for the introduction of advanced laparoscopic surgeries. Copyright © 2009 Springer Science+Business Media, LLC.


Kanehira E.,Medical Topia Soka | Kamei A.,Medical Topia Soka | Umezawa A.,Yotsuya Medical Cube | Kurita A.,Ageo Central General Hospital | And 2 more authors.
Surgical Endoscopy and Other Interventional Techniques | Year: 2016

Background: The treatment options for gastrointestinal stromal tumors (GITSs) at the esophagogastric junction (EGJ) are controversial. There have been reports on enucleation for EGJ GISTs in order to avoid gastrectomy. But the number of patients is too small, or the follow-up period is too short to evaluate it. The purpose of this study was to review our experience of 59 patients with EGJ GISTs treated by enucleation by percutaneous endoscopic intragastric surgery (PEIGS) and assess the clinical outcomes. Methods: PEIGS is performed as described below. Access ports are placed through the abdominal wall and the anterior wall of the stomach. Through the access ports, an endoscope and surgical instruments are inserted into the gastric lumen and tumor enucleation and closure of the defect are carried out. In this study, 59 patients with EGJ GISTs treated by PEIGS between 2005 and 2013 were enrolled. Their hospital records were reviewed, and follow-up data for 8 years were collected to analyze the outcomes. Results: En-bloc enucleation was achieved without tumor rupture in all. Average operation time was 172.3 min. Postoperative complications occurred in 3 (one localized peritonitis, one bleeding, and one surgical site infection). Average tumor size was 35.6 mm. Pathological findings confirmed negative margin in all specimens. The maximum follow-up period was 101 months. Multiple liver metastases were detected in two patients (at 12 and 29 months). The survival rate was 100 %. The disease-free rate was 98.3 % at 12 months and 96.6 % at 29 months, respectively. Conclusions: As far as the short- and long-term outcomes of our experience are reviewed, PEIGS seems as curative as other aggressive resection methods such as proximal gastrectomy. Tumor enucleation by PEIGS, offering a chance to preserve the stomach, can be a preferable option in carefully selected patients with EGJ GISTs, when performed by a skilled surgeon. © 2015, Springer Science+Business Media New York.


Yabe S.,Niigata University | Takano T.,Niigata University | Higuchi W.,Niigata University | Mimura S.,Ageo Central General Hospital | And 2 more authors.
Journal of Infection and Chemotherapy | Year: 2010

The USA300 clone is a highly-virulent community-acquired methicillin-resistant Staphylococcus aureus, which has been predominant in the United States. In a previous study, we isolated the USA300 clone from an 11-month-old Japanese girl, who lived in Saitama (Japan), and suffered from cellulitis and sepsis, and subsequently osteomyelitis, in 2008. In this study, we searched for the source of such USA300 infection in three related families (the patient's grandfather and grandmother, having a USA300-infected daughter [F2D], and a mother [F3M] who was a sister of F2D's mother). In January, 2008, F3M and her family members visited Hawaii and were treated in a hospital for gastroenteritis (with diarrhea) with an intravenous drip for F3M. After their return to Japan in January, F3M suffered from unusually frequent (more than 10 times) skin soft-tissue infections (SSTIs) until successful chemotherapy in July in Saitama. In the same summer season, SSTI was observed in 7 of 11 family members (63.6%). This dense spread of SSTI was followed by cellulitis and sepsis (USA300-isolated case) in October and subsequent osteomyelitis in December in F2D. After successful chemotherapy for the patient (F2D), no new SSTI cases were observed among the family members, and no USA300 colonization was observed when examined in December, 2009. The data suggest the first spread of the USA300 clone in Japan with related families at the core and that such USA300 spread in the community is likely to have occurred in the summer season in Japan. © 2010 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

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