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Syamsuddin M.,Padjadjaran University | Saitoh S.-I.,Hokkaido University | Hirawake T.,Hokkaido University | Syamsudin F.,The Agency for the Assessment and Application of Technology BPPT | Zainuddin M.,Hasanuddin University
International Journal of Remote Sensing | Year: 2016

Remotely derived environmental variables, including sea surface height anomaly (SSHA), sea surface temperature (SST), chlorophyll-a (chl-a), eddy kinetic energy (EKE), mixed layer data set of argo float (MLD), Niño 3.4 index, and bigeye tuna catch data for the period 1997–2008, were used to analyse ocean climate variability and how they relate to the hotspots of bigeye tuna catch in the eastern Indian Ocean off Java. The empirical orthogonal function (EOF) was performed to obtain a more detailed structure of the spatio-temporal ocean variability in the region. The results showed that the first EOF modes of chl-a, SSHA, and SST accounted for 42.8%, 36.5%, and 27.4% of total variance, respectively, and these corresponded to the interannual signal. The maps of spatial patterns of the first EOF modes of SSHA, SST, and chl-a gave very typical values for cold-water SSHA, low SST, and high chl-a concentration along the southern coast of the Indonesian archipelago; and warm-water SSHA, high SST, and low chl-a concentration in the offshore region to make frontal areas along the latitudinal line around 10–12º S. The EOF analysis further revealed a strong relationship between the El Niño event and favourable oceanographic conditions, resulting in a significant increase in bigeye tuna catch. The average hook rate of 0.71 (0.43) was recorded during El Niño (La Niña). Major hotspots were located away from the confluence region and frontal areas around 11–16° S and 110–118° E and were thus demonstrated as the most favourable oceanographic conditions for bigeye tuna fishing in the eastern Indian Ocean off Java. © 2016 Taylor & Francis


Park J.-W.,Korea Research Institute of Bioscience and Biotechnology | Park J.-W.,Korea University | Kwon O.-K.,Korea Research Institute of Bioscience and Biotechnology | Kwon O.-K.,Chungnam National University | And 6 more authors.
International Journal of Molecular Medicine | Year: 2016

Lagerstroemia ovalifolia Teijsm. & Binn. has traditionally been used as an herbal medicine and possesses anti inflammatory properties. However, the mechanisms underlying its anti-inflammatory effects remain poorly understood. For this purpose, we aimed to investigate the effects of methanolic extract of L. ovalifolia (LOME) on nitric oxide (NO) and prostaglandin E2 (PGE2) production, as well as the underlying molecular mechanisms responsible for these effects, in lipopolysaccharide (LPS)stimulated RAW264.7 macrophages. We examined the effects of LOME on the production of NO and PGE2 in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of LOME, we measured the mRNA or protein expression of the pro inflammatory mediators induced by LOME in the LPS-stimulated RAW264.7 cells. LOME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1, and tumor necrosis factor-(TNF-) in LPS-stimulated RAW264.7 cells. Moreover, LOME suppressed the mRNA and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and inhibited the phosphorylation of the mitogen-activated protein kinases (MAPKs), with a reduction in the nuclear translocation of nuclear factor (NF)-B in LPS-stimulated RAW264.7 cells. Taken together, these findings suggest that LOME may exert anti-inflammatory effects in vitro in LPS-stimulated RAW264.7 macrophages and thus, may have potential for use as an adjuvant treatment of inflammatory diseases.


PubMed | Korea University, Chungnam National University, The Agency for the Assessment and Application of Technology BPPT and Korea Research Institute of Bioscience and Biotechnology
Type: Journal Article | Journal: International journal of molecular medicine | Year: 2016

Lagerstroemia ovalifolia Teijsm. & Binn. has traditionally been used as an herbal medicine and possesses anti-inflammatory properties. However, the mechanisms underlying its anti-inflammatory effects remain poorly understood. For this purpose, we aimed to investigate the effects of methanolic extract of L.ovalifolia(LOME) on nitric oxide(NO) and prostaglandinE2(PGE2) production, as well as the underlying molecular mechanisms responsible for these effects, in lipopolysaccharide(LPS)stimulated RAW264.7 macrophages. We examined the effects of LOME on the production of NO and PGE2 in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of LOME, we measured the mRNA or protein expression of the proinflammatory mediators induced by LOME in the LPS-stimulated RAW264.7 cells. LOME significantly inhibited the production of NO, PGE2, interleukin(IL)-6, IL-1, and tumor necrosis factor-(TNF-) in LPS-stimulated RAW264.7 cells. Moreover, LOME suppressed the mRNA and protein expression of inducible nitric oxide synthase(iNOS), cyclooxygenase-2(COX-2) and inhibited the phosphorylation of the mitogen-activated protein kinases(MAPKs), with a reduction in the nuclear translocation of nuclear factor(NF)-B in LPS-stimulated RAW264.7 cells. Taken together, these findings suggest that LOME may exert anti-inflammatory effects invitro in LPS-stimulated RAW264.7 macrophages and thus, may have potential for use as an adjuvant treatment of inflammatory diseases.


PubMed | Korea University, The Agency for the Assessment and Application of Technology BPPT and Korea Research Institute of Bioscience and Biotechnology
Type: Journal Article | Journal: International journal of molecular medicine | Year: 2015

Rhododendron album Blume (RA) has traditionally been used as an herbal medicine and is considered to have anti-inflammatory properties. In the present study, we screened RA extracts with anti-inflammatory properties. The biological effects of an RA methanol extract (RAME) on inflammation were investigated in lipopolysaccharide (LPS)-stimulated mouse RAW264.7 cells. We investigated the effects of RAME on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of RAME, we measured the mRNA and protein expression of pro-inflammatory mediators induced by RAME in the LPS-stimulated RAW264.7 cells by RT-PCR and western blot analysis, respectively. RAME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)- in the LPS-stimulated RAW264.7 cells. It also suppressed the mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and mitogen-activated protein kinases (MAPKs) with a concomitant decrease in the nuclear translocation of nuclear factor-B (NF-B) in the LPS-stimulated RAW264.7 cells. These results indicate that RAME inhibits LPS-induced inflammatory responses. These effects were considered to be strongly associated with the suppression of NF-B activation. We therefore suggest that RAME may be prove to be an effective therapeutic agent for the treatment of inflammatory diseases.


Sahlan M.,University of Indonesia | Yuliani H.,University of Indonesia | Yuliani H.,The Agency for the Assessment and Application of Technology BPPT | Hermansyah H.,University of Indonesia | Wijanarko A.,University of Indonesia
ASEAN Journal of Chemical Engineering | Year: 2013

Biodegradation of polyaromatic hydrocarbons (PAHs) are catalyzedby multicomponent enzymes from microbe. The initial dioxygenase was used as a key enzyme for attacking the aromatic ring structure of PAHs, furthermore its initial dioxygenase gene was used to select PAHs degrading bacteria. Marine bacteria M128 strain could grow on medium contained PAHs. Detection of its cellular initial deoxygenase gene was done by nahAcgene amplification. The nahAcgene commonly used as biomarkers of PAH degradation, and as a result, nahAcgene sequence analysis of marine bacteria M128strain was similar to naphthalene dioxygenase of Pseudomonas genera with 99% homology.

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