Agence nationale de securite sanitaire de lalimentation

Maisons-Alfort, France

Agence nationale de securite sanitaire de lalimentation

Maisons-Alfort, France

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Grant
Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2013.3.5-02 | Award Amount: 1.21M | Year: 2013

The objective of the PreSto GMO ERA-Net project is to clearly map out the steps needed to create and successfully implement an ERA-Net that will coordinate transnational research on the effects of genetically modified organisms (GMOs) in the areas of human and animal health, the environment, and techno- economics and societies. The focus of the ERA-Net will be on GMOs intentionally released into the environment and/or used immediately in feed and food applications. PreSto GMO ERA-Net brings together ministries, agencies, and funding bodies from different Members States and the scientific community to jointly prepare a strategic plan and roadmap for the implementation of the ERA-Net. In addition, the ERA-Net will explicitly take into account the wider views of a diversity of stakeholders and end-users (e.g. non-governmental organisations, industry, farmers). This is intended to strengthen ownership of the ERA-Net among stakeholders in order to encourage participation of different scientific communities in the future joint transnational calls, to enhance collaboration between actors and to increase the accountability of research trajectories and outcomes. The results of the project will form the basis for a robust ERA-Net proposal. In achieving this the project work will (1) promote the accessibility of existing scientific information to interested stakeholders and end-users, (2) lead to the harmonisation of research requirements and capacity building within Europe, (3) complement international developments, (4) contribute to a more efficient use of research funds internationally and (5) identify how strategic collaboration can be used to respond to these future research and training needs through enhancement of durable partnerships.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-05 | Award Amount: 11.61M | Year: 2013

EFFORT studies the complex epidemiology and ecology of antimicrobial resistance and the interactions between bacterial communities, commensals and pathogens in animals, the food chain and the environment.This will be conducted by a combination of epidemiological and ecological studies using newly developed molecular and bio-informatics technologies. EFFORT will include an exposure assessment of humans from animal/environmental sources. The ecological studies on isolates will be verified by in vitro and in vivo studies. Moreover, real-life intervention studies will be conducted aiming at reducing the use of antimicrobials in veterinary practice. Focus will be on understanding the eco-epidemiology of antimicrobial resistance from animal origin and based on this, predicting and limiting the future evolution and exposure to humans of the most clinically important resistance by synthesising different sources of information in our prediction models. Through its results, the EFFORT research will provide scientific evidence and high quality data that will inform decision makers, the scientific community and other stakeholders about the consequences of AMR in the food chain, in relation to animal health and welfare, food safety and economic aspects. These results can be used to support political decisions and to prioritize risk management options along the food chain. The EFFORT consortium is made up of 20 partners from 10 European countries: Belgium, Bulgaria, Denmark, France, Germany, Italy, the Netherlands, Poland, Spain and Switzerland. The senior investigators leading this proposal bring together complementary strengths antimicrobial resistance, food safety, epidemiology of food borne pathogens and risk modelling, environmental epidemiology and microbial ecology, exposure assessment, veterinary microbiology, preventive molecular characterization of AMR, genetics and biology of DNA transfer mechanisms, whole genome sequencing for bacteria and economics of animal diseases


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-01 | Award Amount: 3.92M | Year: 2013

The project intends to address the risk of emerging viral vector borne diseases in two main categories of arthropods known to transmit important animal and zoonotic diseases: mosquitoes (Aedes and Culex), and Culicoides biting midges. A research proposal targeting potential emerging viral disease risks related to these vectors will be carried out through original and integrated multidisciplinary approaches including: - Study of virus and microbial communities by next-generation sequencing (NGS) methodsin vectors collected in targeted ecosystems, providing an unprecedented global understanding of the role of the microbial and environmental ecology in virus emergence and transmission. It will also permit the discovery of new potential pathogens and the development of innovative diagnostic methods for surveillance and new tools for intervention strategies; - Characterization of vector competence mechanisms in selected vector-virus couples, including mosquitoes / Rift Valley fever virus (RVFV) and Culicoides / Schmallenberg virus (SBV) and Orbiviruses; - Development of vector distribution and disease transmission models; - Development of better maps of high-risk areas for vector presence, as well as disease emergence and spread taking into account the impact of globalization, including climate changes and intensification of human and animal movements; - Design of new surveillance frameworks accounting for these new diagnostic methods, new knowledge and risk assessment analyses, for improved strategies of vectors, domestic and wild susceptible speciessurveillance by national and regional authorities; - Improvement of intervention strategies against vector borne diseases; Owing to this field of investigations, the project has a high potential for industrial and commercial outputs in Europethrough diagnostic kits, vaccines and computational software.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.3-3 | Award Amount: 49.52M | Year: 2013

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answers needed by regulators and legislators on EHS by linking them to a scientific evaluation of data and test methods. Based on questions and requirements supplied by regulators and legislators, NANoREG will: (i) provide answers and solutions from existing data, complemented with new knowledge, (ii) Provide a tool box of relevant instruments for risk assessment, characterisation, toxicity testing and exposure measurements of MNMs, (iii) develop, for the long term, new testing strategies adapted to innovation requirements, (iv) Establish a close collaboration among authorities, industry and science leading to efficient and practically applicable risk management approaches for MNMs and products containing MNMs. The interdisciplinary approach involving the three main stakeholders (Regulation, Industry and Science) will significantly contribute to reducing the risks from MNMs in industrial and consumer products. NANoREG starts by analysing existing knowledge (from WPMN-, FP- and other projects). This is combined with a synthesis of the needs of the authorities and new knowledge covering the identified gaps, used to fill the validated NANoREG tool box and data base, conform with ECHAs IUCLID DB structure. To answer regulatory questions and needs NANoREG will set up the liaisons with the regulation and legislation authorities in the NANoREG partner countries, establish and intensify the liaisons with selected industries and new enterprises, and develop liaisons to global standardisation and regulation institutions in countries like USA, Canada, Australia, Japan, and Russia.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2013-2 | Award Amount: 2.69M | Year: 2013

Campylobacteriosis is the most frequently reported zoonotic illness at the EU in 2011, with 9 million human cases, and a total annual cost of 2.4 billion per year in the EU27. Poultry meat is the major single source of human infection. Recent studies have shown that European broiler flocks have a high prevalence of Campylobacter colonization with an average of 71%. However, there is still no effective, reliable and practical strategy available to prevent or to reduce Campylobacter colonization in broilers. The objective of the present project is to develop a two-steps strategy in order to fight against Campylobacter in primary poultry production: first step nutritional approach, through the use of a synergic combination of different products such as plant extracts (PE), organic acids (OA), prebiotics (PRE), probiotics (PRO), and feed presentation (FP) through 4 work packages (WPs) in which trials with infected broilers and in experimental and real conditions will be done. In a second step, vaccination approach based on a novel development of a Campylobacter vaccine through the use of reverse vaccinology. The expected results of the project will be a short term strategy through new nutritional strategies based on a synergic combination of feed products and feed presentation and a medium term strategy through a novel vaccine to reduce the prevalence of Campylobacter in broiler flocks. The consortium is formed by five National poultry producers SME-AGs (PROPOLLO, FIA, CIDEF, NEPLUVI and BTT), two RTD (ANSES, and IMASDE) and three SMEs (MIKROLAB, REDONDO, and CZV).


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.4-04 | Award Amount: 12.16M | Year: 2013

Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate knowledge derived from their application and new knowledge from intervention studies into FOOD ALLERGY MANAGEMENT plans and dietary advice. The resulting holistic strategies will reduce the burden of food allergies in Europe and beyond, whilst enabling the European food industry to compete in the global market place. Our approach will build on e-Health concepts to allow full exploitation of complex data obtained from the work in this proposal and previous and ongoing studies, maximising sharing and linkage of data, by developing an informatics platform Allerg-e-lab. This will enable us to (1) Extend and integrate existing cohorts from observation and intervention studies to provide evidence as to how maternal diet and infant feeding practices (including weaning) modulate the patterns and prevalence of allergies across Europe (2) Establish risk factors for the development of severe reactions to food and identify associated biomarkers (3) Develop a clinically-validated tiered risk assessment and evidence-based risk management approach for food allergens for allergens in the food chain (4) Develop clinically-relevant multi-analyte methods of analysis suited to allergen management across the food chain Stakeholders will be integrated into iFAAM to deliver harmonised integrated approaches, including RISK ASSESSORS AND MANAGERS managing population risk, the FOOD INDUSTRY who manage allergens to ensure consumer safety, HEALTH CARE PRACTITIONERS to provide food allergy management plans and dietary advice and ALLERGIC CONSUMERS to manage individual risk.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2011.2.4-02 | Award Amount: 7.58M | Year: 2012

Total Diet Studies (TDS) allow getting information on real dietary exposure to food contaminants consumption (heavy metals, mycotoxins, POPs...) and estimating chronic exposure to pesticide residues in food and food additives intake. TDS consider total exposure from whole diets and are based on food contamination as consumed rather than contamination from raw commodities, thus ensuring a realistic exposure measure. TDS facilitate risk assessment (RA) and health monitoring (HM). Some EU Member States (MS) and Candidate Countries (CC) have no TDS programme or use various methods to collect data, which were not examined yet to tell whether they are comparable or not. This is of interest for EFSA or WHO-FAO. Similarly it is important to harmonise methods to assess dietary exposure risks in MS, CC and at the European level compared with other world regions. The methods proposed will aim for food sampling, standard analytical procedures, exposure assessment modelling, priority foods and selected chemical contaminants consistency across MS and CC. Various approaches and methods to identify sampling and analyses will be assessed and best practice defined. Contaminants and foods which contribute most to total exposure in European populations will be defined. Priority will be given to training and support in EU MS and CC currently without TDS. It will demonstrate best practice in creating a TDS programme using harmonised methods in regions previously lacking TDS, and ensure consistency of data collected. A database will be set up describing existing EU studies and collating harmonised exposure measures and designed to allow risk assessors and managers handling dietary exposure more accurately and more specifically. TDSEXPOSURE will spread excellence in TDS throughout stakeholders and establish a legacy of harmonised methods for sampling and analysis, and science-based recommendations for future global studies.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-02 | Award Amount: 7.76M | Year: 2014

Global apiculture is facing an unprecedented crisis of increasing parasite pressure and a loss of hon-eybee biodiversity. SMARTBEES unites a team of experts with the necessary skills to build a bright and sustainable future. The SMARTBEES concept is low risk and high impact, using established protocols and state-of-the-art methods. Including world leading researchers from outwith the traditional honeybee sphere (e.g. acarology, genetic breeding and insect immunology). We will identify crucial facets of honeybee resistance to colony losses, Varroa and viruses. We will provide a step-change in the current mechanistic understanding of these traits, and will characterise the genetic background of the resistance mechanisms in honeybees. We will develop breeding strategies to increase the frequencies of these valuable traits in local honeybee populations, considering the variable need of both common and endangered subspecies and local beekeeping practises. Breeding efforts concentrating on very few races may endanger genetic diversity, to avoid this SMARTBEES will promote multiple local breeding efforts, to conserve local resilient populations and will develop molecular tools for describing and safeguarding future populations. SMARTBEES recognizes responsibility to protect our natural honeybee heritage. SMARTBEES will commission extension science, and work in cooperation with stakeholders to attain conservation by utilisation. SMARTBEES will establish a network of apiaries for performance testing, to encourage local uptake of resistant traits. These will be run mainly by beekeepers, thereby improving the local acceptability and dissemination, and support the long-term sustainability of the apicultural sector. SMARTBEES recognises the need to horizon scan for new threats, and the consortium includes the current EU reference laboratory to that end. SMARTBEES is an opportunity to make a lasting difference to the health, resilience and genetic diversity of our honeybees.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.4-02 | Award Amount: 5.06M | Year: 2013

Despite many efforts to ensure that only high-quality and safe products are put on the market, fish-borne parasites continue to pose risks to human health, with zoonotic infections and allergic reactions mainly following consumption of raw, lightly cooked, or marinated seafood. The PARASITE proposal is presented by a multidisciplinary consortium of 12 European and 3 Asian research institutions and 6 European SMEs. It aims to provide new scientific evidence and technological developments to detect, monitor, and mitigate impacts of zoonotic parasites, mainly anisakid nematodes but also trematode metacercariae, occurring in European and imported fishery products. The Project will address the research needs identified by EFSA regarding the risk of seafood-borne parasites. It also will facilitate close cooperation between scientists and end-users to produce new technological solutions and management tools for both European and imported fishery products. The Work Plan has been organized in 9 work packages, each covering different stages of a risk assessment framework, providing new epidemiological data, monitoring tools, development and implementation of parasite detection devices, technological tools for their mitigation, and dissemination of key results to all the stakeholders and the general public. Risk assessment of zoonotic parasites will ensure significant progress beyond the state of the art. This will be achieved by improving molecular hazard identification, antigen/allergen characterization, parasite exposure assessment, detection methods and treatments for industrial and other end-users, and an integrated quantitative risk analysis based on powerful statistics and modelling, The main results will impact by (1) contributing to enhanced seafood safety, with consequent benefits for public health and consumer confidence, (2) strengthening the competitiveness of European seafood, from the net to the plate and (3) improving EU food safety policies.

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