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Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.4-04 | Award Amount: 12.16M | Year: 2013

Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate knowledge derived from their application and new knowledge from intervention studies into FOOD ALLERGY MANAGEMENT plans and dietary advice. The resulting holistic strategies will reduce the burden of food allergies in Europe and beyond, whilst enabling the European food industry to compete in the global market place. Our approach will build on e-Health concepts to allow full exploitation of complex data obtained from the work in this proposal and previous and ongoing studies, maximising sharing and linkage of data, by developing an informatics platform Allerg-e-lab. This will enable us to (1) Extend and integrate existing cohorts from observation and intervention studies to provide evidence as to how maternal diet and infant feeding practices (including weaning) modulate the patterns and prevalence of allergies across Europe (2) Establish risk factors for the development of severe reactions to food and identify associated biomarkers (3) Develop a clinically-validated tiered risk assessment and evidence-based risk management approach for food allergens for allergens in the food chain (4) Develop clinically-relevant multi-analyte methods of analysis suited to allergen management across the food chain Stakeholders will be integrated into iFAAM to deliver harmonised integrated approaches, including RISK ASSESSORS AND MANAGERS managing population risk, the FOOD INDUSTRY who manage allergens to ensure consumer safety, HEALTH CARE PRACTITIONERS to provide food allergy management plans and dietary advice and ALLERGIC CONSUMERS to manage individual risk.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-07-2014 | Award Amount: 20.85M | Year: 2014

COMPARE aims to harness the rapid advances in molecular technology to improve identification and mitigation of emerging infectious diseases and foodborne outbreaks. To this purpose COMPARE will establish a One serves all analytical framework and data exchange platform that will allow real time analysis and interpretation of sequence-based pathogen data in combination with associated data (e.g. clinical, epidemiological data) in an integrated inter-sectorial, interdisciplinary, international, one health approach. The framework will link research, clinical and public health organisations active in human health, animal health, and food safety in Europe and beyond, to develop (i) integrated risk assessment and risk based collection of samples and data, (ii) harmonised workflows for generating comparable sequence and associated data, (iii) state-of-the-art analytical workflows and tools for generating actionable information for support of patient diagnosis, treatment, outbreak detection and -investigation and (iv) risk communication tools. The analytical workflows will be linked to a flexible, scalable and open-source data- and information platform supporting rapid sharing, interrogation and analysis of sequence-based pathogen data in combination with other associated data. The system will be linked to existing and future complementary systems, networks and databases such as those used by ECDC, NCBI and EFSA. The functionalities of the system will be tested and fine tuned through underpinning research studies on priority pathogens covering healthcare-associated infections, food-borne disease, and (zoonotic) (re-) emerging diseases with epidemic or pandemic potential. Throughout the project, extensive consultations with future users, studies into the barriers to open data sharing, dissemination and training activities and studies on the cost-effectiveness of the system will support future sustainable user uptake.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-02 | Award Amount: 7.76M | Year: 2014

Global apiculture is facing an unprecedented crisis of increasing parasite pressure and a loss of hon-eybee biodiversity. SMARTBEES unites a team of experts with the necessary skills to build a bright and sustainable future. The SMARTBEES concept is low risk and high impact, using established protocols and state-of-the-art methods. Including world leading researchers from outwith the traditional honeybee sphere (e.g. acarology, genetic breeding and insect immunology). We will identify crucial facets of honeybee resistance to colony losses, Varroa and viruses. We will provide a step-change in the current mechanistic understanding of these traits, and will characterise the genetic background of the resistance mechanisms in honeybees. We will develop breeding strategies to increase the frequencies of these valuable traits in local honeybee populations, considering the variable need of both common and endangered subspecies and local beekeeping practises. Breeding efforts concentrating on very few races may endanger genetic diversity, to avoid this SMARTBEES will promote multiple local breeding efforts, to conserve local resilient populations and will develop molecular tools for describing and safeguarding future populations. SMARTBEES recognizes responsibility to protect our natural honeybee heritage. SMARTBEES will commission extension science, and work in cooperation with stakeholders to attain conservation by utilisation. SMARTBEES will establish a network of apiaries for performance testing, to encourage local uptake of resistant traits. These will be run mainly by beekeepers, thereby improving the local acceptability and dissemination, and support the long-term sustainability of the apicultural sector. SMARTBEES recognises the need to horizon scan for new threats, and the consortium includes the current EU reference laboratory to that end. SMARTBEES is an opportunity to make a lasting difference to the health, resilience and genetic diversity of our honeybees.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2013.3.5-02 | Award Amount: 1.21M | Year: 2013

The objective of the PreSto GMO ERA-Net project is to clearly map out the steps needed to create and successfully implement an ERA-Net that will coordinate transnational research on the effects of genetically modified organisms (GMOs) in the areas of human and animal health, the environment, and techno- economics and societies. The focus of the ERA-Net will be on GMOs intentionally released into the environment and/or used immediately in feed and food applications. PreSto GMO ERA-Net brings together ministries, agencies, and funding bodies from different Members States and the scientific community to jointly prepare a strategic plan and roadmap for the implementation of the ERA-Net. In addition, the ERA-Net will explicitly take into account the wider views of a diversity of stakeholders and end-users (e.g. non-governmental organisations, industry, farmers). This is intended to strengthen ownership of the ERA-Net among stakeholders in order to encourage participation of different scientific communities in the future joint transnational calls, to enhance collaboration between actors and to increase the accountability of research trajectories and outcomes. The results of the project will form the basis for a robust ERA-Net proposal. In achieving this the project work will (1) promote the accessibility of existing scientific information to interested stakeholders and end-users, (2) lead to the harmonisation of research requirements and capacity building within Europe, (3) complement international developments, (4) contribute to a more efficient use of research funds internationally and (5) identify how strategic collaboration can be used to respond to these future research and training needs through enhancement of durable partnerships.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.4-02 | Award Amount: 5.06M | Year: 2013

Despite many efforts to ensure that only high-quality and safe products are put on the market, fish-borne parasites continue to pose risks to human health, with zoonotic infections and allergic reactions mainly following consumption of raw, lightly cooked, or marinated seafood. The PARASITE proposal is presented by a multidisciplinary consortium of 12 European and 3 Asian research institutions and 6 European SMEs. It aims to provide new scientific evidence and technological developments to detect, monitor, and mitigate impacts of zoonotic parasites, mainly anisakid nematodes but also trematode metacercariae, occurring in European and imported fishery products. The Project will address the research needs identified by EFSA regarding the risk of seafood-borne parasites. It also will facilitate close cooperation between scientists and end-users to produce new technological solutions and management tools for both European and imported fishery products. The Work Plan has been organized in 9 work packages, each covering different stages of a risk assessment framework, providing new epidemiological data, monitoring tools, development and implementation of parasite detection devices, technological tools for their mitigation, and dissemination of key results to all the stakeholders and the general public. Risk assessment of zoonotic parasites will ensure significant progress beyond the state of the art. This will be achieved by improving molecular hazard identification, antigen/allergen characterization, parasite exposure assessment, detection methods and treatments for industrial and other end-users, and an integrated quantitative risk analysis based on powerful statistics and modelling, The main results will impact by (1) contributing to enhanced seafood safety, with consequent benefits for public health and consumer confidence, (2) strengthening the competitiveness of European seafood, from the net to the plate and (3) improving EU food safety policies.

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