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Le Touquet – Paris-Plage, France

Thomasson R.,University of Orleans | Baillot A.,University of Orleans | Jollin L.,University of Orleans | Lecoq A.-M.,University of Orleans | And 3 more authors.
Journal of Physiological Sciences | Year: 2010

This study examined the relationships between plasma and saliva adrenocortical hormones in response to long-duration submaximal exercise. In nine healthy, physically active, female volunteers, blood and saliva samples were taken at rest and every 30 min during a 120-min cycling trial at 50-55% VO2max for cortisol and dehydroepiandrosterone (DHEA) analysis. Correlation analysis revealed a moderate but significant relationship between plasma and saliva cortisol (r = 0.35, P < 0.02) and plasma and saliva DHEA (r = 0.47, P < 0.001) during the submaximal exercise. When expressed in percent of resting values, the correlations between the plasma and saliva concentrations were higher for both hormones during the exercise (cortisol: r = 0.72; DHEA: r = 0.68, P < 0.001). The results thus suggest that, even under prolonged exercise conditions, non-invasive saliva samples may offer a practical approach to assessing pituitary-adrenal function, especially when compared with individual basal values. © 2010 The Physiological Society of Japan and Springer. Source

Marijon E.,French Institute of Health and Medical Research | Marijon E.,University of Paris Descartes | Tafflet M.,French Institute of Health and Medical Research | Tafflet M.,University of Paris Descartes | And 17 more authors.
Circulation | Year: 2011

BACKGROUND-: Although such data are available for young competitive athletes, the prevalence, characteristics, and outcome of sports-related sudden death have not been assessed previously in the general population. METHODS AND RESULTS-: A prospective and comprehensive national survey was performed throughout France from 2005 to 2010, involving subjects 10 to 75 years of age. Case detection for sports-related sudden death, including resuscitated cardiac arrest, was undertaken via national ambulance service reporting and Web-based screening of media releases. The overall burden of sports-related sudden death was 4.6 cases per million population per year, with 6% of cases occurring in young competitive athletes. Sensitivity analyses used to address suspected underreporting demonstrated an incidence ranging from 5 to 17 new cases per million population per year. More than 90% of cases occurred in the context of recreational sports. The age of subjects was relatively young (mean±SD 46±15 years), with a predominance of men (95%). Although most cases were witnessed (93%), bystander cardiopulmonary resuscitation was only commenced in 30.7% of cases. Bystander cardiopulmonary resuscitation (odds ratio 3.73, 95% confidence interval 2.19 to 6.39, P<0.0001) and initial use of cardiac defibrillation (odds ratio 3.71, 95% confidence interval 2.07 to 6.64, P<0.0001) were the strongest independent predictors for survival to hospital discharge (15.7%, 95% confidence interval 13.2% to 18.2%). CONCLUSIONS-: Sports-related sudden death in the general population is considerably more common than previously suspected. Most cases are witnessed, yet bystander cardiopulmonary resuscitation was only initiated in one third of cases. Given the often predictable setting of sports-related sudden death and that prompt interventions were significantly associated with improved survival, these data have implications for health services planning. Copyright © 2011 American Heart Association. Source

Collomp R.,Nice University Hospital Center | Labsy Z.,University Paris - Sud | Zorgati H.,University Paris - Sud | Prieur F.,University Paris - Sud | And 6 more authors.
Endocrine | Year: 2014

Significant alteration in hypothalamic-pituitary-adrenal function has been demonstrated in patients after short-term glucocorticoid therapy, but its impact on the circadian rhythm of steroid hormones has never been investigated. This study examined the effects of short-term prednisone administration on the diurnal patterns of dehydroepiandrosterone (DHEA) and testosterone. Saliva samples were collected from 11 healthy, physically active, male volunteers for DHEA and testosterone analysis, as follows: every 4 h from 0800 to 2000 h on 2 control days without medication, and after 1 week of oral therapeutic prednisone treatment (60 mg daily) (days 0-3). Overall, a diurnal decline in the two steroid hormones was observed on the control days. After short-term glucocorticoid administration, DHEA concentrations were significantly decreased with a complete disappearance of the DHEA diurnal pattern, which lasted 2 days post-treatment. No glucocorticoid effect was observed for testosterone. The results indicate that short-term prednisone treatment affects the circadian pattern of saliva DHEA but not testosterone in healthy active volunteers. Further studies are necessary to determine whether this alteration in DHEA circadian pattern has clinical consequences in patients with chronic glucocorticoid therapy. © 2013 Springer Science+Business Media. Source

Dubecq C.,British Petroleum | Daniel Y.,Antenne medicale specialisee de Lorient Lanester | Aigle L.,Center Medical Des Armees Of Calvi | Bigard X.,Agence francaise de lutte contre le dopage
Science and Sports | Year: 2014

Background: The consumption of nutritional supplements has increased in various sports. This overuse might be dangerous for health. The aim of this work is to assess the prevalence of supplement use among French soldiers based in Afghanistan, and relationship between consumption and military deployment. We investigated also the reasons for taking such supplements. Methods: Between April and September 2012, French soldiers were invited to complete an anonymous survey while regulatory activities. Data were keyed into the Epi data™ v3.1 entry software; statistical analyses were conducted using the Epi info™ v3.5.1 software. Chi square (χ2) analysis and analysis of variance (ANOVA) were used. Results: One thousand three hundred and ninety-one French soldiers completed the survey. The prevalence of supplement use was 20.6% (IC95%. =. 18.5%-22.8%). Also, 75.9% of consumers started during deployment. Among them, 71.1% did not use any dietary supplement in France. The top reported motivations were muscle gain (62.5% of users), improved recovery (57.7%), sport performance (56.5%) and physical appearance (56.0%). Only 22.9% of users considered that their job performance was enhanced. Conclusions: Among the French soldiers, 20.6% use ergogenic aids during their deployment, and this consumption was associated to this new military environment. Esthetical motivations are as important as sport motivations. Prevention and information messages should be provided to soldiers. © 2014 Elsevier Masson SAS. Source

Collomp K.,University of Orleans | Buisson C.,Agence francaise de lutte contre le dopage | Lasne F.,Agence francaise de lutte contre le dopage | Collomp R.,Nice University Hospital Center
Journal of Steroid Biochemistry and Molecular Biology | Year: 2015

The dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) concentrations during acute and chronic exercise (training) have been investigated only fairly recently. DHEA is generally preferred to DHEA-S for exploring the acute exercise repercussions in laboratory or field tests because of its shorter elimination half-life. Conversely, DHEA-S is preferred to estimate chronic adaptations. Both can be measured noninvasively in saliva, and it is therefore possible to follow these hormone responses in elite athletes during competitive events and in healthy and pathological populations, without imposing additional stress. Indeed, the correlation between saliva and serum concentrations is high for steroid hormones, both at rest and during exercise. In this review, we will first summarize the current knowledge on the DHEA/DHEA-S responses to exercise and examine the potential modulating factors: exercise intensity, gender, age, and training. We will then discuss the ergogenic effects that athletes expect from the exogenous administration of DHEA and the antidoping methods of analysis currently used to detect this abuse. © 2014 Elsevier Ltd. All rights reserved. Source

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