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Das R.S.,Agartala Government Medical College
Nepal Medical College journal : NMCJ | Year: 2011

Monosodium Glutamate (MSG) has been in use since long as a flavour enhancing substance. Its widespread use has also earned it a bad name to be harmful for human health. It had been incriminated in wide range of effects comprising retinal degeneration, metabolic disorders, endocrinal disorders including reduced fertility rate in both in both sexes in mice. However there were many contradicting views too, which have prompted us to undertake the present study. For our study eight female newborns of Swiss Albino mice were injected subcutaneously with MSG (2mg / gm of body wt. in a dilution 40 mg of per ml. of distilled water) on completion of 2nd, 4th, 6th, 8th and 10th day of life. Another five mice pups were injected with same volume of distilled water and taken as control. On completion of 75 days the mice were sacrificed of, ovaries were collected through dissection, 5 micron thick sections were cut and stained by H and E and PAS stain and studied under light microscope. It was observed from the quantitative analysis of the ovarian tissue that there was increase in the number of the primary follicle without increase in number of Graffian follicle in the experimental group.

Bhattacharjee K.,Agartala Government Medical College
Journal of Datta Meghe Institute of Medical Sciences University | Year: 2016

Background: Sebaceous carcinoma is a rare aggressive malignant tumor derived from the adnexal epithelium of sebaceous glands. It is most commonly seen in the orbital region. Amongst extraocular sites, axilla is a very rare site of involvement. A case of rapidly growing sebaceous carcinoma of the axilla occurring in a young male with lymph node metastasis is reported. We emphasize the need to be aware of such an aggressive tumor at rare sites and the need to know the etiology better as it is no longer bound by age limits. © 2016, Datta Meghe Institute of Medical Sciences Deemed University. All rights reserved.

Gangwal C.,Tripura University | Bhaumik R.N.,UGC | Kumar S.,Agartala Government Medical College
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

This paper presents an intuitionistic fuzzy (IF) rough relational database model. The IF rough relational database model extends the IF and rough relational database models along with an IF rough relational algebra for querying. The usefulness of this model was illustrated with the Diabetic patients of Tripura where the various types of uncertainties are presented. For this study, first we design our database with an IF rough E-R diagram, created our database schema using an IF rough data definition and manipulation language (DDL and DML). Using IF Rough SQL-like languages, we then illustrate how the IF rough relational database may be queried and how the results are better than those of conventional databases. © 2013 Springer-Verlag.

Talukdar F.R.,Assam University | Ghosh S.K.,Assam University | Laskar R.S.,Assam University | Kannan R.,Assam University | And 5 more authors.
Molecular Carcinogenesis | Year: 2015

Human papillomavirus (HPV) has been recently associated with squamous cell carcinoma of upper aerodigestive tract (SCC of UADT), but its possible role in promoting aberrant methylation in these tumors has largely remained unexplored. Herein, we investigated the association of HPV with aberrant methylation in tumor-related genes/loci consisting of the classical CpG Island Methylator Phenotype (CIMP) panel markers (p16, MLH1, MINT1, MINT2, and MINT31) and other frequently methylated cancer-related genes (DAPK1, GSTP1, BRCA1, ECAD, and RASSF1) and survival of UDAT cancers. The study includes 219 SCC of UADT patients from different hospitals of Northeast India. Detection of HPV and aberrant promoter methylation was performed by PCR and Methylation Specific PCR respectively. Association study was conducted by Logistic regression analysis and overall survival analysis was done by Kaplan-Meier plot. HPV was detected in 37% of cases, with HPV-18 as the major high-risk sub-type. Although HPV presence did not seem to affect survival in overall UADT cancers, but was associated with a favourable prognosis in head and neck squamous cell carcinoma. Hierarchical clustering revealed three distinct clusters with different methylation profile and HPV presence. Among these, the CIMP-high subgroup exhibited the highest HPV positive cases (66%). Furthermore, multivariate analysis revealed a strong synergistic association of HPV and tobacco towards modulating promoter hypermethylation in UADT cancer (OR=27.50 [95% CI=11.51-88.03] for CIMP-high vs. CIMP-low). The present study proposes a potential role of HPV in impelling aberrant methylation in specific tumor related loci, which might contribute in the initiation and progression of SCC of UADT. © 2014 Wiley Periodicals, Inc.

Kumar S.,Agartala Government Medical College
Mymensingh medical journal : MMJ | Year: 2013

Reduction of malarial morbidity and mortality is one of the top public health priorities in Tripura and the Country. To achieve these targets it is imperative to have active community participation to control malaria. Community participation in turn depends on people's knowledge and attitude towards the disease. This study was conducted to examine the factors that predict the knowledge of rural tribal communities in Dhalai district of Tripura towards malaria. This community based epidemiological cross-sectional descriptive study was carried out in Dhalai district of Tripura. A pre-tested structured questionnaire collecting socio-demographic and malaria-related KAP information was administered to the 216 adult respondents from a representative sample of households. As a whole, there were 147(68.1%) illiterate respondents. Out of them, 89(41.2%) persons were male and 58(26.9%) were female. Correct knowledge about the cause of malaria was 2.77 times higher in males than females and 11.53 times higher in literate tribal people than in illiterate. Correct knowledge about the symptoms fever, chills, and rigors of malaria were also higher in male sex and in literate tribal people. Use of smoke as preventive measure was very high among the respondents. Common predictors of correct knowledge about etiology and clinical features of malaria were in male Tripuri and Reang community. Use of smoke for killing of adult mosquito was predicted by illiteracy. Promotion of literacy and participation in health education are vital component in terms of knowledge and practice.

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