Agartala Government Medical College

Agartala, India

Agartala Government Medical College

Agartala, India

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Gangwal C.,Tripura University | Bhaumik R.N.,UGC | Kumar S.,Agartala Government Medical College
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

This paper presents an intuitionistic fuzzy (IF) rough relational database model. The IF rough relational database model extends the IF and rough relational database models along with an IF rough relational algebra for querying. The usefulness of this model was illustrated with the Diabetic patients of Tripura where the various types of uncertainties are presented. For this study, first we design our database with an IF rough E-R diagram, created our database schema using an IF rough data definition and manipulation language (DDL and DML). Using IF Rough SQL-like languages, we then illustrate how the IF rough relational database may be queried and how the results are better than those of conventional databases. © 2013 Springer-Verlag.


Majumdar T.,Agartala Government Medical College | Bhattacharya S.,Agartala Government Medical College | Barman D.,Agartala Government Medical College | Bhoumik P.,Agartala Government Medical College | Bir R.,Agartala Government Medical College
International Journal of Tuberculosis and Lung Disease | Year: 2016

BACKG ROUND: Multidrug-resistant tuberculosis (MDR-TB) poses a global threat that is further compounded by the human immunodeficiency virus (HIV) epidemic. OBJECTIVE: To detect MDR-TB among pulmonary TB (PTB) patients with or without HIV coinfection by isolating and identifying Mycobacterium tuberculosis from clinical samples and performing drug susceptibility testing (DST). METHODS: Sputum was collected from presumed PTB cases. Microscopic examination was performed following Ziehl-Neelsen (ZN) staining and cultured in Löwenstein-Jensen (LJ) medium. First-line anti-tuberculosis DST of the isolates was performed using MGITe (Mycobacterial Growth Indicator Tube) and multiplex allele-specific polymerase chain reaction (MAS-PCR). RESULTS: Of 172 study subjects, 59.3% (102/172) were smear-positive and 40.7% (70/172) were smearnegative. In the smear-positive and-negative groups, respectively 62.7% (64/102) and 8.6% (6/70) were culture-positive. DST on MGIT showed a cumulative resistance of 7.1% (5/70) to isoniazid (INH) and rifampicin. More ethambutol (EMB) and combined INH+EMB resistance was detected using MAS-PCR. CONCLUSION: MDR-TB is a problem in Tripura, and culture and phenotypic DST are required for diagnosis. MAS-PCR may provide an alternative rapid screening tool. © 2016 The Union.


Bhattacharjee K.,Agartala Government Medical College | Moitra N.,Agartala Government Medical College
Journal of Datta Meghe Institute of Medical Sciences University | Year: 2014

Background :- Cervical cytology has not only been useful in screening for cervical intra-epithelial neoplasia (CIN) lesions but is also of value in the characterization of various infections of female genital tract. The present study is an attempt to provide recent update on the outcome of cervical cytology in randomly selected patients. The sample population were 895 randomly selected sexually active women attending the gynaecology and family planning clinics in the Department of Obstetrics and Gynaecology of the Agartala Government Medical College & GBP Hospital, Agartala, Tripura during October 2012 to September 2013. A questionnaire determining the age, parity, family history, and complaints etc. of the patients was administered. Patients with age group of 18-70 years were considered having complaints like vaginal discharge, bleeding per vagina or something coming out per vagina. The pap smears of these patients were examined microscopically. 895 women screened in different age group with overall percentage. Maximum numbers of patients screened belongs to 40-50 yrs. of age (41.79 %) and minimum nos. of patients screened belongs to 18-28 yrs. of age (8.94%). Out of the 895 cervico-vaginal smears studied, 515 (57.48%) showed inflammatory (benign/reactive) cytomorphology, 20 (2.2%) showed atrophic cyto- morphology, 25 (2.8%) smears showed metaplasia, 37 (4.12 %) showed ASCUS, 4(0.5%) showed AGUS, 1(0.1%) showed evidences of LSIL, 1(0.1%) showed HSIL, 6(0.7%) showed cytomorphology of SCC, 4(0.4 %) showed changes of radiation induced atypia. ASCUS has 4.1 % while AGUS has 0.5% incidence. The gynaecologic examinations revealed cervical erosion in 19 (2.1%), vaginitis in 217 (24.2%) and normal findings in 328 (36.6%); while pathological evaluation reports of the smears were negative in 175 (19.5%), inflammation in 107 (11.9%), ASCUS in 37 (4.1%) and AGUS in 4(0.5%). Among 49 smears showing atypical/abnormal cytomorphological lesions, 92% had complaint of vaginal discharge, 56% had history of multiparity, 59% belonged to low socioeconomic group, 62% had early marriage, and 66% belonged to post menopausal age. In this study certain specific infections (fungal / protozoal) were identified and the overall prevalence of these infections is 29.8%, with Candida albicans constituting the highest prevalence of 45.3% of all infections. This study has shown the importance of cervical cytology in the diagnosis of other genital tract conditions besides screening for CIN. The Papanicolaou smear for cervical cytology fulfils all the criteria for an ideal screening test. Not only it is cost effective, acceptable to most patients and adaptable to wide spread screenings, it is also specific enough for stopping subsequent progression to cervical intra-epithelial Neoplasia (CIN) thus resulting in decreased morbidity and mortality from invasive cervical cancer. © 2014, Datta Meghe Institute of Medical Sciences Deemed University. All rights reserved.


Nath B.,P.A. College | sarkar P.,Agartala Government Medical College | das T.,Agartala Government Medical College
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2014

Though foreign bodies of ear are quite commonly encountered in our day-to-day practice, self-inflicted penetrating injury of ear is not common. One such case of selfinflicted penetrating injury of ear with giant sized nail is presented here. In this patient the nail had traversed the whole thickness of skull and the pointed end of the nail could be traced at opposite temporal area. Extraction of the nail was posed with great difficulties as it was deeply impacted inside the dense bone of skull base. Miraculously, post-operative morbidity was very minimal in this case both in terms of intracranial tissue damage and hearing impairment. © 2012 Association of Otolaryngologists of India.


Das R.S.,Agartala Government Medical College
Nepal Medical College journal : NMCJ | Year: 2011

Monosodium Glutamate (MSG) has been in use since long as a flavour enhancing substance. Its widespread use has also earned it a bad name to be harmful for human health. It had been incriminated in wide range of effects comprising retinal degeneration, metabolic disorders, endocrinal disorders including reduced fertility rate in both in both sexes in mice. However there were many contradicting views too, which have prompted us to undertake the present study. For our study eight female newborns of Swiss Albino mice were injected subcutaneously with MSG (2mg / gm of body wt. in a dilution 40 mg of per ml. of distilled water) on completion of 2nd, 4th, 6th, 8th and 10th day of life. Another five mice pups were injected with same volume of distilled water and taken as control. On completion of 75 days the mice were sacrificed of, ovaries were collected through dissection, 5 micron thick sections were cut and stained by H and E and PAS stain and studied under light microscope. It was observed from the quantitative analysis of the ovarian tissue that there was increase in the number of the primary follicle without increase in number of Graffian follicle in the experimental group.


Bhattacharjee K.,Agartala Government Medical College
Journal of Datta Meghe Institute of Medical Sciences University | Year: 2016

Background: Sebaceous carcinoma is a rare aggressive malignant tumor derived from the adnexal epithelium of sebaceous glands. It is most commonly seen in the orbital region. Amongst extraocular sites, axilla is a very rare site of involvement. A case of rapidly growing sebaceous carcinoma of the axilla occurring in a young male with lymph node metastasis is reported. We emphasize the need to be aware of such an aggressive tumor at rare sites and the need to know the etiology better as it is no longer bound by age limits. © 2016, Datta Meghe Institute of Medical Sciences Deemed University. All rights reserved.


Das R.S.,Agartala Government Medical College
Nepal Medical College journal : NMCJ | Year: 2010

Monosodium glutamate (MSG), popularly known as Azinomoto has been in use since long as a flavour enhancing substance. Its widespread use has also earned it a bad name as hazardous for human health. It has been incriminated to cause wide range of effects comprising retinal degeneration, metabolic disorders, endocrinal disorders including reduced fertility rate in both male and female experimental mice and rats following neonatal exposure. However there are many contradicting views too regarding the above effects which have prompted us to undertake the present study. In our study seven newborns of Swiss Albino mice were injected subcutaneously with MSG (2 mg/gm ofbody wt. in a dilution 40 mg of per ml. of distilled water) on completion of 2nd, 4th, 6th, 8th and 10th day of life. Similar number of controls were injected with same volume of distilled water. Testes were obtained through dissection on completion of 75 days of life. 5 micron thick sections were cut, stained by H.E. and Heidenhain's Iron Haematoxylin and studied under light microscope. It was observed from the quantitative analysis of the seminiferous tubules that there was increase in the number of the pachytene stage of primary spermatocyte in the experimental group as compared to that of the control animals of corresponding age.


Kumar S.,Agartala Government Medical College
Mymensingh medical journal : MMJ | Year: 2013

Reduction of malarial morbidity and mortality is one of the top public health priorities in Tripura and the Country. To achieve these targets it is imperative to have active community participation to control malaria. Community participation in turn depends on people's knowledge and attitude towards the disease. This study was conducted to examine the factors that predict the knowledge of rural tribal communities in Dhalai district of Tripura towards malaria. This community based epidemiological cross-sectional descriptive study was carried out in Dhalai district of Tripura. A pre-tested structured questionnaire collecting socio-demographic and malaria-related KAP information was administered to the 216 adult respondents from a representative sample of households. As a whole, there were 147(68.1%) illiterate respondents. Out of them, 89(41.2%) persons were male and 58(26.9%) were female. Correct knowledge about the cause of malaria was 2.77 times higher in males than females and 11.53 times higher in literate tribal people than in illiterate. Correct knowledge about the symptoms fever, chills, and rigors of malaria were also higher in male sex and in literate tribal people. Use of smoke as preventive measure was very high among the respondents. Common predictors of correct knowledge about etiology and clinical features of malaria were in male Tripuri and Reang community. Use of smoke for killing of adult mosquito was predicted by illiteracy. Promotion of literacy and participation in health education are vital component in terms of knowledge and practice.


PubMed | Agartala Government Medical College
Type: Journal Article | Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease | Year: 2016

Multidrug-resistant tuberculosis (MDR-TB) poses a global threat that is further compounded by the human immunodeficiency virus (HIV) epidemic.To detect MDR-TB among pulmonary TB (PTB) patients with or without HIV coinfection by isolating and identifying Mycobacterium tuberculosis from clinical samples and performing drug susceptibility testing (DST).Sputum was collected from presumed PTB cases. Microscopic examination was performed following Ziehl-Neelsen (ZN) staining and cultured in Lwenstein-Jensen (LJ) medium. First-line anti-tuberculosis DST of the isolates was performed using MGIT (Mycobacterial Growth Indicator Tube) and multiplex allele-specific polymerase chain reaction (MAS-PCR).Of 172 study subjects, 59.3% (102/172) were smear-positive and 40.7% (70/172) were smear-negative. In the smear-positive and -negative groups, respectively 62.7% (64/102) and 8.6% (6/70) were culture-positive. DST on MGIT showed a cumulative resistance of 7.1% (5/70) to isoniazid (INH) and rifampicin. More ethambutol (EMB) and combined INH+EMB resistance was detected using MAS-PCR.MDR-TB is a problem in Tripura, and culture and phenotypic DST are required for diagnosis. MAS-PCR may provide an alternative rapid screening tool.


PubMed | Sambalpur University, Immunology group and Agartala Government Medical College
Type: Journal Article | Journal: Antimicrobial agents and chemotherapy | Year: 2016

Population level variation of drug metabolism phenotype (DMP) has great implications in treatment outcome, drug-related side effects, and resistance development. In this study, we used a gas chromatography-time of flight-mass spectrometry (GC-TOF-MS)-based untargeted urine metabolomics approach to understand the DMP of a tuberculosis (TB) patient cohort (n= 20) from Tripura, a state in the northeastern part of India. Urine samples collected at different postdose time points (2 h, 6 h, 12 h, 24 h, 36 h, and 48 h) from these newly diagnosed TB patients receiving first-line anti-TB drugs were analyzed, and we have successfully detected three of the four first-line drugs,viz, isoniazid (INH), ethambutol (ETB), and pyrazinamide (PZA). The majority of their known metabolites, acetyl-isoniazid (AcINH), isonicotinic acid (INA), isonicotinuric acid (INTA), 2,2-(ethylenediimino)-dibutyric acid (EDBA), 5-hydroxypyrazinamide (5OH-PZA), pyrazinoic acid (POA), and 5-hydroxypyrazinoic acid (5OH-POA), were also detected. Analyzing the variation in abundances of drugs and their known metabolites and calculating the metabolic ratios in these samples, we offer comprehensive DMP information on this small patient cohort that represents Tripura, India. The majority (75%) of these patients are found to be slow acetylators of INH. The average metabolic ratios of POA/PZA and 5OH-POA/POA are 3.16 3.03 and 6.09 6.15, respectively. Employing correlation analysis of the metabolomics metadata and a manual prediction of drug catabolism, we have proposed 2-aminobutyric acid (AABA) as a novel metabolite of ETB. These observations indicate the usefulness of GC-MS-based metabolomics to characterize the DMP at a population level and also to identify novel drug metabolites.

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