Afzal Research Center

Kermān, Iran

Afzal Research Center

Kermān, Iran
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Zangiabadi N.,Kerman Medical University | Zangiabadi N.,Afzal Research Center | Shafiee K.,Kerman Medical University | Alavi K.H.,Afzal Research Center | And 2 more authors.
Minerva Endocrinologica | Year: 2012

Aim. Statins are widely used amongst diabetic patients. Recently, it has been proposed that they may exert many beneficial effects on vascular function regardless of their cholesterol lowering action. There are also growing concerns about statins-induced polyneuropathy in diabetic patients. As far as we know, this is the first clinical trial that has studied the effect of atorvastatin on electrophysiological parameters in diabetic neuropathy. Methods. This was a randomized, double-blind, placebo-controlled clinical trial that assessed nerve conduction velocity (NCV) parameters after a six-month therapy with atorvastatin, 20 mg per day. Results. Although there was an 11% difference in Motor to F-wave conduction velocity ratio (M/F ratio) between the studied group and the controls, this difference was not statistically significant. Motor conduction velocity (MCV) significantly improved by 5% (P<0.05) and the F wave was not significantly deteriorated. Conclusion. In conclusion, treatment with statins may have a beneficial effect on diabetic neuropathy electrophysiological changes, at least in the short-ter.

Zangiabadi N.,Kerman Medical University | Zangiabadi N.,Afzal Research Center | Yarahmadi F.,Islamic Azad University | Darekordi A.,Chamran University of Ahvaz | And 2 more authors.
Hemoglobin | Year: 2013

The present study aimed at investigating and comparing patients suffering from β-thalassemia (β-thal) minor with normal individuals in regard to their performances in the short version of the Wechsler Adult Intelligence Scale (WAIS) test. Patients with β-thal minor are carriers of β-thal genes. They have mild microcytic and hypochromic anemia and are usually asymptomatic. In this cross-sectional study, a total of 60 individuals were divided into two equal groups of β-thal minor and normal subjects; they were then studied by the WAIS subscales. The mean performance scores of the normal group in the subtests of arithmetic and vocabulary (p <0.01) and picture completion (p <0.05) were higher than those of the thalassemia group. The mean performance score and ability of the normal group on the verbal scale was higher in comparison to the thalassemia group (p <0.05), while on the non verbal scale, there was no significant difference between the two groups. It can be concluded that β-thal minor negatively influences verbal fluency, reasoning and conceptualization, and sequencing tasks, perceptual skill, prediction of social situations and abstract thinking. Copyright © Informa Healthcare USA, Inc.

Zangiabadi N.,Kerman Medical University | Zangiabadi N.,Afzal Research Center | Mohtashami H.,Kerman Medical University | Hojatipour M.,Kerman Medical University | And 3 more authors.
Scientific World Journal | Year: 2014

Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ). Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups. The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks. Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group. Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats. Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats. © 2014 Nasser Zangiabadi et al.

Zangiabadi N.,Kerman Medical University | Zangiabadi N.,Afzal Research Center | Asadi-Shekaari M.,Kerman Medical University | Sheibani V.,Kerman Medical University | And 5 more authors.
Oxidative Medicine and Cellular Longevity | Year: 2011

Background. To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats. Methods. The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and vehicle group with respect to the following parameters: open field behavioral test, motor nerve conduction velocity (MNCV), and morphological observations. Results. In the model of STZ-induced of diabetic neuropathy, chronic treatment for 6 weeks with DFE counteracted the impairment of the explorative activity of the rats in an open field behavioral test and of the conduction velocity of the sciatic nerve (MNCV). In addition, pretreatment with DFE significantly reversed each nerve diameter reduction in diabetic rats. Conclusion. DFE treatment shows efficacy for preventing diabetic deterioration and for improving pathological parameters of diabetic neuropathy in rats, as compared with control groups. Copyright © 2011 Nasser Zangiabadi et al.

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