Palo Alto, CA, United States
Palo Alto, CA, United States

Time filter

Source Type

The present invention relates to a peptide-based compound comprising a peptide moiety and a poly(ethylene glycol) (PEG) moiety wherein the PEG moiety, which is preferably linear, has a molecular weight of more than 20 Kdaltons. The peptide moiety may be monomeric, dimeric or oligomeric. Such peptide-based compounds may optionally include a linker moiety and/or a spacer moiety, and are useful in drug delivery.


The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water-soluble polymer moiety. The spacer moiety has the structure: -NH-(CH_(2))_()-[O-(CH_(2))_()]_()-O_()-(CH_(2))_()-Y-wherein , , , ,and are each integers whose values are independently selected.


The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water-soluble polymer moiety. The spacer moiety has the structure: NH(CH_(2))_()[O(CH_(2))_()]_()O_()(CH_(2))_()Y wherein , , , , and are each integers whose values are independently selected.


Patent
Affymax Inc. | Date: 2010-11-12

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.


Patent
Affymax Inc. | Date: 2012-07-03

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.


Patent
Affymax Inc. | Date: 2012-11-01

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.


Patent
Affymax Inc. | Date: 2010-12-10

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.


Patent
Affymax Inc. | Date: 2012-11-27

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.


Patent
Affymax Inc. | Date: 2012-10-18

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.


Compounds comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety are disclosed. Various linker moieties for use in these compounds are also disclosed, along methods for their synthesis.

Loading Affymax Inc. collaborators
Loading Affymax Inc. collaborators