Zhang T.-Y.,Sun Yat Sen University |
Zhang T.-Y.,Affiliated Tumor Hospital of Zunyi Medical College |
Niu S.-Q.,Sun Yat Sen University |
Zhang Y.-J.,Sun Yat Sen University
World Chinese Journal of Digestology | Year: 2016
AIM: To assess the effect of radiotherapy on prognosis of stage IE/IIE gastric mucosaassociated lymphoid tissue (MALT) lymphoma. METHODS: The records of 35 patients treated for stage IE/IIE MALT lymphoma at Sun Yatsen University Cancer Center between June 24, 1997 and October 27, 2011 were retrospectively reviewed, including cases who received radiotherapy followed by chemotherapy, 9 cases who received surgery followed by chemotherapy, and 11 cases who received chemotherapy alone. The curves of progression-free survival (PFS) and overall survival (OS) were calculated by the Kaplan-Meier method, and their significance was calculated by the log-rank tests. The curves of PFS and OS were compared among the three groups of patients. RESULTS: The median follow-up time was 44.50 mo (range, 0.67 to 155.10 mo). Ten cases recurred, including 3 cases receiving surgery followed by chemotherapy, and7 cases receiving chemotherapy alone. By multiple comparisons, the curve of PFS for cases receiving radiotherapy followed by chemotherapy had a statistical difference compared to those receiving chemotherapy alone (P = 0.043), but showed no statistical difference compared to those receiving surgery followed by chemotherapy (P = 0.195). The curve of OS for cases receiving radiotherapy followed by chemotherapy did not differ significantly from that for cases receiving surgery followed by chemotherapy (P = 0.304). No severe adverse reactions such as gastric hemorrhage or perforation occurred in cases receiving radiotherapy followed by chemotherapy. CONCLUSION: Radiotherapy followed by chemotherapy is associated with significantly longer PFS in the treatment of stage IE/IIE gastric MALT lymphoma compared to chemotherapy alone or surgery followed by chemotherapy, although OS had no significant difference in the three groups. © 2016 Baishideng Publishing Group Inc. All rights reserved.