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Wang H.,Affiliated Hospital of Academy of Military Medical science 307 Hospital of PLA | Liu Z.,Affiliated Hospital of Academy of Military Medical science 307 Hospital of PLA
Cell Biochemistry and Biophysics | Year: 2014

The current large-scale meta-analysis was performed to reach a reliable conclusion on the association between X-ray repair cross-complementing 1 (xrcc1) rs1799782 and the development of lung cancer. Studies that investigated the association between rs1799782 and lung cancer risk were identified by searching PubMed. We calculated odds ratio (OR) with corresponding 95 % confidence interval (CI) for Trp/Trp vs Arg/Arg, Trp/Trp + Arg/Trp vs Arg/Arg, and Trp/Trp vs Arg/Trp + Arg/Arg contrast models. Combining all 25 studies, we yielded three summary ORs: 1.07 (95 % CI 0.92–1.23) for Trp/Trp vs Arg/Arg, 0.93 (95 % CI 0.87–1.00) for Trp/Trp + Arg/Trp vs Arg/Arg, and 1.08 (95 % CI 0.94–1.25) for Trp/Trp vs Arg/Trp + Arg/Arg, suggesting rs1799782 was not associated with overall risk of lung cancer. Strikingly, a significantly deceased risk was found among Caucasian populations (Trp/Trp + Arg/Trp vs Arg/Arg, OR = 0.86, 95 % CI 0.76–0.97). This study confirms that xrcc1 rs1799782 may lower the risk of lung cancer among Caucasians. © 2014, Springer Science+Business Media New York.


Wang H.,Affiliated Hospital of Academy of Military Medical science 307 Hospital of PLA | Liu Z.,Affiliated Hospital of Academy of Military Medical science 307 Hospital of PLA
Cell Biochemistry and Biophysics | Year: 2014

BSF2 polymorphism is believed to affect the transcriptional capability of the gene. Studies of lung cancer have associated BSF2 polymorphism with risk of lung cancer, only failing to identify whether this polymorphism predisposes an individual variation in the susceptibility to the malignant cancer. The primary aim of this study was to determine the association. An exhaustive literature search was conducted in the Medline and CNKI databases. Based on the data extracted from each of the included studies, we estimated the risk of lung cancer ascribed to BSF2 polymorphism by calculating ORs and its 95 % CIs. When pooling all eligible studies into the meta-analysis, we did not see any evidence suggesting there was a significant association between BSF2 polymorphism and risk of lung cancer. For the studies of Caucasian sample, the effects were exactly the same as those observed in the overall comparison. Our results suggest that BSF2 polymorphism may not predispose genetic susceptibility toward lung cancer in Caucasian populations, which nevertheless requires additional investigation. © 2014, Springer Science+Business Media New York.


Wang H.,Affiliated Hospital of Academy of Military Medical science 307 Hospital of PLA | Liu Z.-D.,Affiliated Hospital of Academy of Military Medical science 307 Hospital of PLA
Cell Biochemistry and Biophysics | Year: 2014

The knowledge of molecular mechanism that underlies the genetic predisposition to lung cancer is yet limited. Results from previous studies addressing the association of AGPHD1 variant rs8034191 with lung carcinogenesis remain inconclusive. Herein, we combined these data and re-examined the association. We performed a meta-analysis of Asian studies identified through various ways. Using the data collected from each eligible study, we combined the effect estimates (ORs and its 95 % CIs) with the fixed effects model (Mantel–Haenszel method). Statistical analyses were done using STATA software. Data from nine studies (29,290 subjects) carried out in Asian populations were analyzed in this work. There was no overall association between variant rs8034191 and lung cancer risk under the allele frequency model (OR = 1.03, 95 % CI = 0.93–1.13, Pheterogeneity = 0.522). We observed the same associations under other genetic models and in the subgroup analyses by ethnicity and smoking status. Our results indicate that variant rs8034191 in the AGPHD1 gene may not modify the genetic risk of lung cancer in Asian populations. © 2014, Springer Science+Business Media New York.

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