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Ado-Ekiti, Nigeria

Oyinloye B.E.,University of Zululand | Oyinloye B.E.,Afe Babalola University | Adenowo A.F.,University of Zululand | Kappo A.P.,University of Zululand
Pharmaceuticals | Year: 2015

Excessive free radical generation, especially reactive oxygen species (ROS) leading to oxidative stress in the biological system, has been implicated in the pathogenesis and pathological conditions associated with diverse human inflammatory diseases (HIDs). Although inflammation which is considered advantageous is a defensive mechanism in response to xenobiotics and foreign pathogen; as a result of cellular damage arising from oxidative stress, if uncontrolled, it may degenerate to chronic inflammation when the ROS levels exceed the antioxidant capacity. Therefore, in the normal resolution of inflammatory reactions, apoptosis is acknowledged to play a crucial role, while on the other hand, dysregulation in the induction of apoptosis by enhanced ROS production could also result in excessive apoptosis identified in the pathogenesis of HIDs. Apparently, a careful balance must be maintained in this complex environment. Antimicrobial peptides (AMPs) have been proposed in this review as an excellent candidate capable of playing prominent roles in maintaining this balance. Consequently, in novel drug design for the treatment and management of HIDs, AMPs are promising candidates owing to their size and multidimensional properties as well as their wide spectrum of activities and indications of reduced rate of resistance. © 2015 by the authors; licensee MDPI, Basel, Switzerland.


Fasae J.K.,Afe Babalola University | Adegbilero-Iwari I.,Elizade University
Electronic Library | Year: 2016

Purpose - The purpose of this paper is to investigate the use of social media for academic practices by science students of public universities in Southwest Nigeria. Design/methodology/approach - Descriptive design was used for the study. Research instrument used was questionnaire where 140 copies were administered to science students, using purposive sampling technique. Three institutions in southwest of Nigeria were selected for the study. Copies of the questionnaire were distributed to students in their lecture rooms and laboratories during practical classes with the permission and assistance of their lecturers. The data collected were analysed using frequency and simple percentage. Findings - The results reveal that among the various social media networks available, Facebook (93.48 per cent) is the most recognized and most famous, followed by Google+ (63.77 per cent) and Twitter (47.83 per cent). Two-third of the students make use of social media daily to remain up-to-date with trending events/news and to occupy free time when they are bored, among other reasons. The findings show that Google+ (52.17 per cent) is the most beneficial social media network followed by Facebook (29.7 per cent) and Wikia (23.91 per cent). Most of the science students are knowledgeable in the usage and application of social media, while majority of them considered poor Internet connectivity, receiving of unwanted messages/pictures and electricity failure as the leading problems encountered while using social media. Originality/value - The study was necessary to identify the use and application of social media by science students in public universities in Southwest Nigeria. © 2016 Emerald Group Publishing Limited.


Oboh G.,Federal University of Technology Akurre | Agunloye O.M.,Federal University of Technology Akurre | Akinyemi A.J.,Federal University of Technology Akurre | Akinyemi A.J.,Afe Babalola University | And 2 more authors.
Neurochemical Research | Year: 2013

This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO4, sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Combination of the phenolic acids inhibited AChE and BChE activities antagonistically. Furthermore, pro-oxidants such as, FeSO4, sodium nitroprusside and quinolinic acid caused increase in the malondialdehyde (MDA) contents of the brain which was significantly decreased dose-dependently by the phenolic acids. Inhibition of AChE and BChE activities slows down acetylcholine and butyrylcholine breakdown in the brain. Therefore, one possible mechanism through which the phenolic acids exert their neuroprotective properties is by inhibiting AChE and BChE activities as well as preventing oxidative stress-induced neurodegeneration. However, esterification of caffeic acid with quinic acid producing chlorogenic acid affects these neuroprotective properties. © 2012 Springer Science+Business Media New York.


Adeoluwa O.A.,Afe Babalola University | Adeoluwa O.A.,University of Ibadan | Aderibigbe A.O.,University of Ibadan | Olonode E.T.,University of Ibadan
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance: Olax subscorpioidea is a shrub or tree found in Nigeria, and other parts of Africa. It is used in the management of inflammatory disorder, mental illness, convulsion, pain, and cancer. However, there is dearth of information on scientific basis for its folkloric use in the management of pain. Therefore, the study was designed to investigate the antinociceptive property of the extract of Olax subscorpioidea (EOS) leaves in mice. Materials and methods: Antinociceptive activity of EOS (12.5-50 mg/kg, i.p.) was investigated using acetic acid induced abdominal writhing, tail immersion, hot plate and formalin tests. Results: Extract of Olax subscorpioidea produced significant dose dependent inhibition of writhing frequency [F(4,20)=155.9, p < 0.0001] and significant dose dependent inhibition of neurogenic and inflammatory pains [F(4,20)=116.7, p < 0.0001; F(4,20)=40.05, p < 0.0001]. It also produced a significant dose dependent prolongation of the latent period and reaction times in tail immersion and hot plate tests in mice [F(4,20)=19.49, p < 0.0001; F(4,20)=97.95, p < 0.0001]. Conclusion: Olax subscorpioidea possessed potent analgesic action, mediated centrally and peripherally, thus justifying its use in the management of pain. © 2014 Published by Elsevier Ireland Ltd.


Oluwasusi J.O.,Afe Babalola University
Journal of Agricultural and Food Information | Year: 2014

This study aimed to identify the factors that determine the utilization of ICT among agricultural students at tertiary institutions in the South Western Zone of Nigeria. A multistage sampling procedure was used to select 240 respondents from the tertiary institutions. Students were mostly male with a mean age of 23.4 years and enrolled in undergraduate programs. Respondents had a high knowledge of ICT utilization despite poor electricity supply, insufficient financial resources, and inadequate ICT infrastructures. A significant relationship existed between constraints, perception of ICT benefits, and utilization of ICT. ANOVA showed a significant difference in the students' level of ICT utilization (F = 26.791; p <.05). Schools should seek private-sector collaboration to alternatively fund ICT amenities on campuses. © 2014 Copyright Taylor & Francis Group, LLC.

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